Condition

Psychotic Disorders clinical trials and research

• 29Clinical trials
• 17NIH research projects
• 1New in 30 days
• 25Countries

Newest Psychotic Disorders clinical trials

All recruiting trials (29)

• Theta-Burst Transcranial Magnetic Stimulation for Treatment-Resistant Auditory Hallucinations

  This study tests whether theta-burst transcranial magnetic stimulation can lessen persistent auditory verbal hallucinations in adults with schizophrenia-spectrum or psychotic disorders who have not responded to antipsychotic meds.

  Recruiting Ciusss de L'Est de l'Île de Montréal · Montreal, Quebec · NCT07902518

• Small Soteria-inspired unit vs. standard closed ward for acute psychosis

  A randomized or semi-randomized comparison tests whether a small Soteria-style inpatient unit improves outcomes for adults with acute psychosis compared to a conventional closed psychiatric ward.

  Recruiting Jerusalem Mental Health Center · Jerusalem, Jerusalem · NCT07836348

• Accelerated Brain Stimulation for Young People at Risk of Psychosis

  This study tests a five-day accelerated brain-stimulation treatment to see if it is safe and tolerable for young people at risk for psychosis and to explore biomarkers that might show whether it works.

  Recruiting Douglas Mental Health University Institute · Verdun, Quebec · NCT07786714

• Racial differences in how people experience paranoia

  This project will see if brief race-related stressful experiences increase feelings of paranoia in Black American adults who take online surveys.

  Recruiting Indiana University · Bloomington, Indiana · NCT07460453

• Yoga-based group program plus usual care for outpatients with schizophrenia spectrum disorders

  This project will see if a 12-week yoga-based group program added to usual outpatient care helps adults with schizophrenia spectrum disorders reduce stress and symptom-related distress compared with exercise or usual care alone.

  Recruiting Charite University, Berlin, Germany · Berlin · NCT07455929

• Trying the Kiso Mind smartphone app for people with schizophrenia spectrum disorders

  This study tests whether the Kiso Mind smartphone app is acceptable, practical, and helpful for adults with schizophrenia or schizoaffective disorder alongside their usual care.

  Recruiting Charite University, Berlin, Germany · Berlin, State of Berlin · NCT07395206

• Multimodal physical exercise program for people with psychosis on long-acting injectable antipsychotics

  This program will try a supervised, structured exercise course to see if it improves physical fitness, mental well‑being, and metabolic health in adults with psychosis who are on long‑acting injectable antipsychotics.

  Recruiting University of Trás-os-Montes and Alto Douro · Vila Real · NCT07360665

• Preventive behavioral intervention for young adults with psychotic experiences

  This study is testing if a new Resilience Training program can help college freshmen and sophomores who are at risk for serious mental illnesses feel better and prevent issues like psychosis, mood swings, and anxiety.

  Recruiting Massachusetts General Hospital · Charlestown, Massachusetts · NCT06929442

• Understanding sensory profiles of patients using a calming room

  This study looks at how patients in a psychiatric hospital respond to different senses before and after using a calming room to see if their sensory experiences affect their mental health.

  Recruiting Centre Hospitalier Esquirol · Limoges, New Aquitaine · NCT06839950

• Improving heart and metabolic health in people with severe mental illness

  This study is testing a new program to help people with severe mental illness, like schizophrenia, improve their heart and overall health by promoting healthier lifestyles.

  Recruiting at 6 sites Vastra Gotaland Region · Gothenburg and 5 other locations · NCT06781801

• Add CBD to antipsychotic treatment for first-episode psychosis to see if it helps more than placebo

  This study tests whether adding cannabidiol (CBD) to ongoing antipsychotic treatment helps people with a first episode of psychosis who haven’t fully responded to their first antipsychotic, compared with a placebo.

  Recruiting at 2 sites Phase 3 University of Oxford · Vienna and 16 other locations · NCT06778564

• Cognitive Behavioral Therapy for Chronic Pain in Veterans with Serious Mental Illness

  This study will test whether Cognitive Behavioral Therapy for Chronic Pain (CBT-CP) helps Veterans with serious mental illness and chronic low back pain reduce pain-related interference and improve quality of life.

  Recruiting VA Office of Research and Development · Baltimore, Maryland · NCT06758414

• Magnetic Seizure Therapy plus antipsychotics for psychotic disorders

  This trial will test whether adding Magnetic Seizure Therapy to antipsychotic medication helps adults with acute psychotic disorders get better faster and with fewer cognitive side effects than medication alone.

  Recruiting Shanghai Jiao Tong University School of Medicine · Shanghai, Shanghai Municipality and 1 other locations · NCT06581302

• Evaluating ITI-1284 for treating psychosis in Alzheimer's patients

  This study is testing a new medication called ITI-1284 to see if it can help reduce psychotic symptoms in people with Alzheimer's disease.

  Recruiting at 48 sites Phase 2 Intra-Cellular Therapies, Inc. · Anaheim, California and 70 other locations · NCT06540833

• Program to help individuals with psychotic and bipolar disorders manage stigma and disclosure

  This study is testing a new program to help adults with psychotic and bipolar disorders learn how to handle stigma and decide when to share their mental health challenges with others.

  Recruiting Oslo University Hospital · Oslo and 1 other locations · NCT06384755

• Training to improve metacognitive skills in patients with psychotic disorders

  This study is testing whether a group program that teaches metacognitive skills can help people with psychotic disorders improve their thinking and social skills.

  Recruiting University of Jyvaskyla · Vaasa · NCT06005766

• Comparing Avatar Therapy and Cognitive Behavioural Therapy for Hearing Voices

  This study is testing whether Avatar Therapy can help people with long-term hearing voices feel better compared to standard Cognitive Behavioural Therapy.

  Recruiting Swinburne University of Technology · Hawthorn, Victoria · NCT05982158

• Virtual reality program to improve cognitive skills in people with psychosis

  This study tests whether a virtual reality program can help people with psychosis improve their thinking and social skills over six weeks.

  Recruiting The Royal Ottawa Mental Health Centre · Ottawa, Ontario · NCT05973110

• Developing a group treatment to help teens at risk for serious mental illness

  This study is testing a new group program to help high school students with mild signs of depression or anxiety build resilience and prevent serious mental health issues.

  Recruiting Massachusetts General Hospital · Boston, Massachusetts · NCT05962879

• Examining the effects of combined therapy for schizophrenia

  This study is testing whether combining two therapies, one for managing thoughts and another for improving cognitive skills, can help people with schizophrenia do better in their daily lives compared to using just one of the therapies.

  Recruiting at 2 sites University of Toronto · Scarborough Village, Ontario and 1 other locations · NCT05731414

• Using virtual reality avatars to help reduce cannabis use in patients with psychotic disorders

  This study is testing if using virtual reality avatars can help people with psychotic disorders reduce their cannabis use more effectively than regular support.

  Recruiting Ciusss de L'Est de l'Île de Montréal · Montreal, Quebec · NCT05704582

• Evaluating personalized medication based on genetic testing for psychiatric disorders

  This study is testing if giving personalized medication advice based on your genes can help people with mood, anxiety, or psychotic disorders feel better compared to regular medication dosing.

  Recruiting at 8 sites Parnassia Groep · Syracuse, New York and 8 other locations · NCT05656469

• Peer-led intervention for suicide prevention in veterans with serious mental illness

  This study is testing a new support program for veterans with serious mental illness to see if it can help reduce thoughts of suicide and improve their recovery.

  Recruiting VA Office of Research and Development · San Diego, California · NCT05537376

• Psychoeducation for families of young adults with psychotic disorders

  This study is testing a program that teaches families of young adults with psychotic disorders how to better support their loved ones and improve their overall well-being.

  Recruiting at 4 sites University of Alberta · Edmonton, Alberta and 3 other locations · NCT05500001

• Investigating cognitive function in psychosis patients and cannabis users

  This study is testing how taking a break from cannabis for 28 days affects thinking skills and brain activity in people with psychosis and those who use cannabis but don’t have mental health issues.

  Recruiting Douglas Mental Health University Institute · Montreal, Quebec · NCT05445180

• Yoga-based group intervention for in-patients with schizophrenia spectrum disorders

  This study is testing if a yoga program can help in-patients with schizophrenia feel better when combined with their regular treatment.

  Recruiting Charite University, Berlin, Germany · Steglitz, State of Berlin · NCT04730518

• Cognitive training for improving mental health in forensic patients

  This study is testing if a special brain training program can help improve thinking skills and mental health for people in a secure facility.

  Recruiting The Royal Ottawa Mental Health Centre · Ottawa, Ontario · NCT04610697

• Exploring Psychosis in Children and Adolescents

  This study is testing how children and teens with psychosis respond to antipsychotic medications over five years to better understand their conditions and treatment outcomes.

  Recruiting Assistance Publique - Hôpitaux de Paris · Gentilly and 5 other locations · NCT04370730

• Analyzing speech to predict psychosis in at-risk patients

  This study is trying to see if analyzing the way people at high risk for schizophrenia speak can help predict if they will develop psychosis.

  Recruiting at 2 sites University Hospital, Brest · Brest and 2 other locations · NCT03525054

NIH-funded research (17)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Neural Circuitry Resilience in Psychotic Disorders

  Researchers are using ultra-high-field brain scans to understand how brain networks in people with schizophrenia adapt over time, with the goal of finding new ways to improve thinking and daily functioning.

  NIH research Veterans Health Administration · Pittsburgh, United States · NIH-11563768

• Family psychoeducation for adults with psychotic disorders in Tanzania

  A program in Tanzania helps adults with psychotic disorders and their families by delivering group-based psychoeducation to improve daily living and reduce hospital visits.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11524689

• Family psychoeducation for adults with psychotic disorders in Tanzania

  A culturally tailored, group-based program helps families support adults with psychotic disorders in Tanzania, aiming to improve daily functioning and quality of life.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11524688

• Family psychoeducation for adults with psychotic disorders in Tanzania

  A culturally tailored, group-based program for people with psychotic disorders and their families in Tanzania is being tested to see if it improves daily functioning and quality of life.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11524687

• Family support program to help adults with psychotic disorders in Tanzania

  A group-based family education program called KUPAA is being tested to help adults with psychotic disorders in Tanzania feel better and have fewer hospital visits.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11524683

• Cognitive training to improve emotion control in psychotic disorders

  A smartphone-based cognitive training program is tested to help people with psychotic disorders manage their emotions more effectively.

  NIH research University of Georgia · Athens, United States · NIH-11385349

• iTEST: A mobile program to help people with psychosis improve self-awareness of performance

  A mobile, blended training program aims to help adults with psychotic disorders better judge their own abilities to boost daily functioning.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11336863

• Boosting the Arc protein to help thinking and memory in psychotic illnesses

  This project tests whether increasing the brain protein Arc can improve thinking and memory for adults with psychotic disorders like schizophrenia or bipolar disorder.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11325042

• Family psychoeducation for adults with psychotic disorders in Tanzania

  A study tests a culturally tailored group family program to support adults with psychotic disorders and their families in Tanzania, aiming to improve daily functioning and reduce hospital use.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11303249

• 35-year memory and thinking changes in people with psychosis

  This project tracks memory and thinking over 35 years in people who had psychotic disorders and in similar adults without psychosis as they reach older age.

  NIH research State University New York Stony Brook · Stony Brook, United States · NIH-11230256

• Improving self-awareness in individuals with psychotic disorders

  This study is testing a new mobile program called iTEST that helps people with psychotic disorders better understand their own abilities and performance, so they can improve their daily lives and feel better overall.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11195278

• Smartphone brain-training to help people with psychosis manage emotions

  A smartphone-based emotional working memory training program aimed at helping people with psychotic disorders improve control over their emotions.

  NIH research University of Georgia · Athens, United States · NIH-11136921

• Improving cognitive function in psychotic disorders by targeting a specific protein

  This study is looking at how a protein called Arc affects thinking problems in people with conditions like schizophrenia, and it aims to find new treatments that could help improve memory and cognitive skills for those who struggle with these issues.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11134697

• Improving family support for adults with psychotic disorders in Tanzania

  This study is testing a special family support program called KUPAA to see if it helps adults with schizophrenia in Tanzania feel better and live happier lives, by involving their family members in group sessions.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11090451

• Understanding cognitive decline in older adults with psychotic disorders over 35 years

  This study is looking at how thinking and memory skills change as older adults with psychotic disorders age, to better understand when these changes start and how they affect daily life, and it’s for people aged 65 and up who have experienced psychosis.

  NIH research State University New York Stony Brook · Stony Brook, United States · NIH-11009583

• Understanding how brain circuits adapt in people with psychotic disorders

  This study is looking at how the brains of people with schizophrenia change and adapt, especially in relation to thinking skills, to find new ways to help improve those skills.

  NIH research Veterans Health Administration · Pittsburgh, United States · NIH-10980516

• Improving emotion control in people with psychotic disorders

  This study is looking at whether a special smartphone app can help people with psychotic disorders get better at managing their emotions over 20 days, and it will compare the results to see if the app really makes a difference.

  NIH research University of Georgia · Athens, United States · NIH-10495487

Related topics

Quick answers

How many Psychotic Disorders clinical trials are recruiting right now?

29, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 25 countries. The most sites are in Canada (8 trials), United States (7 trials), Germany (5 trials), Spain (3 trials), France (3 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 1, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

Describe your situation →