NIH-funded research R01 grant

Identifying genetic factors for schizophrenia and bipolar disorder in diverse populations

Official title: Integrating case-control transcriptomic and genetic data in admixed individuals to identify disease genes for schizophrenia and bipolar disorder

Funded at University of California Los Angeles · NIH-11030780 · Data updated 2026-11-12

This study is looking at how genes might play a role in schizophrenia and bipolar disorder specifically in Latino individuals, and it will involve gathering information from 1,500 people, including those with these conditions and healthy individuals, to better understand how genetics can affect mental health and treatment options.

More Schizophrenia research and trials

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionUniversity of California Los Angeles
NIH-funded
Lab location1 site (Los Angeles, United States)
Project startApril 6, 2018
Project endJanuary 31, 2028
Funding year2025
Award (this year)$429,700
NIH project number5R01MH115676-08
Project IDNIH-11030780 on NIH RePORTER

Who could benefit from this research

Could help

Ideal candidates for this research include Latino individuals diagnosed with schizophrenia or bipolar disorder, as well as healthy Latino controls.

Less likely to help

Patients who do not identify as Latino or who have other mental health conditions unrelated to schizophrenia or bipolar disorder may not benefit from this research.

What this research studies

This research investigates the genetic and molecular factors that contribute to schizophrenia and bipolar disorder, focusing specifically on Latino individuals. By integrating genetic data with transcriptomic information, the study aims to uncover causal relationships between genetic variants and these mental health conditions. The research will involve collecting and analyzing data from 1,500 Latino participants, including those diagnosed with schizophrenia and bipolar disorder, as well as healthy controls. This approach seeks to enhance understanding of how genetic diversity impacts disease susceptibility and treatment.

Why it matters

Potential benefit: If successful, this research could lead to more effective, personalized treatments for schizophrenia and bipolar disorder, particularly for Latino populations.

How similar studies have gone: Previous research has shown success in identifying genetic factors for these disorders in European populations, but this study aims to expand that knowledge to underrepresented Latino populations.

Where this research is happening

  • University of California Los Angeles
    Los Angeles, United States
    Active

Researchers

  • Principal investigator: Ophoff, Roel a — University of California Los Angeles
  • Study coordinator: Ophoff, Roel a

Related research

Other NIH-funded projects on the same topics.

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.