Identifying genetic factors for schizophrenia and bipolar disorder in diverse populations
Integrating case-control transcriptomic and genetic data in admixed individuals to identify disease genes for schizophrenia and bipolar disorder
This study is looking at how genes might play a role in schizophrenia and bipolar disorder specifically in Latino individuals, and it will involve gathering information from 1,500 people, including those with these conditions and healthy individuals, to better understand how genetics can affect mental health and treatment options.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-11030780 on NIH RePORTER |
What this research studies
This research investigates the genetic and molecular factors that contribute to schizophrenia and bipolar disorder, focusing specifically on Latino individuals. By integrating genetic data with transcriptomic information, the study aims to uncover causal relationships between genetic variants and these mental health conditions. The research will involve collecting and analyzing data from 1,500 Latino participants, including those diagnosed with schizophrenia and bipolar disorder, as well as healthy controls. This approach seeks to enhance understanding of how genetic diversity impacts disease susceptibility and treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research include Latino individuals diagnosed with schizophrenia or bipolar disorder, as well as healthy Latino controls.
Not a fit: Patients who do not identify as Latino or who have other mental health conditions unrelated to schizophrenia or bipolar disorder may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective, personalized treatments for schizophrenia and bipolar disorder, particularly for Latino populations.
How similar studies have performed: Previous research has shown success in identifying genetic factors for these disorders in European populations, but this study aims to expand that knowledge to underrepresented Latino populations.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Ophoff, Roel a — University of California Los Angeles
- Study coordinator: Ophoff, Roel a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.