Using brain stimulation to improve thinking skills in people with mental health conditions

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effects of transcranial direct current stimulation (tDCS) on enhancing executive function in individuals with various neuropsychiatric disorders, including traumatic brain injury, major depressive disorder, bipolar disorder, schizophrenia, and ADHD. Participants will receive tDCS treatment, and their cognitive improvements will be assessed compared to a cohort of healthy controls. The study aims to provide insights into the potential of tDCS as a therapeutic intervention for cognitive deficits associated with these conditions.

Why it matters

Who can join: the full rules

Inclusion Criteria

1. Male and female outpatients 18-65 years of age
2. A diagnosis of traumatic brain injury, major depressive disorder, bipolar disorder, schizophrenia, attention deficit hyperactivity disorder, borderline personality disorder and substance use disorders meeting the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) criteria.

Exclusion Criteria

1. Contraindication to tDCS: history or epilepsy, metallic implants in the head and neck, brain stimulators, vagus nerve stimulators, shunts, pacemakers, pregnancy.
2. Active substance dependence (except for tobacco and cannabis).
3. Pregnant or nursing females.
4. Inability to participate in testing procedures.
5. Additional exclusion criteria for healthy controls:

   1. Diagnosis of psychiatric of neurological disorder
   2. Ongoing treatment with any psychotropic medications.

Where it's running

• Massachusetts General Hospital
  Boston, Massachusetts, United States Recruiting

Study contacts

• Principal investigator: Joan Camprodon, MD, PhD, MPH — Massachusetts General Hospital
• Study coordinator: Joan Camprodon, MD, PhD, MPH
• Phone: 6177265348

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.