Preventive intervention for young people at risk of severe mental illness

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This research focuses on a new preventive intervention aimed at young individuals aged 9-21 who are at high risk of developing severe mental illnesses such as schizophrenia, bipolar disorder, and major depression. The study will evaluate the acceptability and efficacy of a cognitive-behavioral intervention that targets early warning signs, or antecedents, of severe mental illness, including anxiety and unusual sensory experiences. Participants will be compared to a non-intervention group to assess the impact of the intervention on emotional distress and social functioning, with the ultimate goal of reducing the risk of developing severe mental illness in the long term.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* FORBOW (Families Overcoming Risks and Building Opportunities for Well-Being) participant between 9-21 years old
* Meet criteria for one or more antecedents (psychotic like experience, basic symptoms, anxiety or affective lability)

Exclusion Criteria:

* Diagnosis of severe mental illness (schizophrenia, other psychotic disorder, bipolar disorder, severe major depressive disorder)
* More than 3 sessions of structured psychological therapy in the past 12 months
* Insufficient understanding of the English language to benefit from the intervention

Where it's running

• Nova Scotia Health Authority
  Halifax, Nova Scotia, Canada Recruiting
• Nova Scotia Health Authority
  Halifax, Nova Scotia, Canada Enrolling by invitation

Study contacts

• Principal investigator: Rudolf Uher, MD PhD — Nova Scotia Health Authority

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.