Condition

Psychosis clinical trials and research

• 68Clinical trials
• 243NIH research projects
• 22Countries

Newest Psychosis clinical trials

All recruiting trials (68)

• State Representation in Early Psychosis 2

  This observational study tests how people with early psychosis and healthy individuals use state information during tasks and how brain activity supports it.

  Recruiting at 2 sites University of Minnesota · Minneapolis, Minnesota and 1 other locations · NCT07834203

• Recovery-oriented suicide prevention for young people at clinical high risk for psychosis

  This program tests a peer-supported, clinician-led suicide prevention group for young people at clinical high risk for psychosis to see if it helps reduce suicidal thoughts and support recovery.

  Recruiting at 2 sites University of California, San Diego · Los Angeles, California and 1 other locations · NCT07756567

• Combined brain stimulation and yoga for improving cognition in psychosis

  This study tests whether active brain stimulation plus yoga can improve thinking skills and daily function in adults with psychosis.

  Recruiting The Hong Kong Polytechnic University · Hung Hom, Kowloon · NCT07747181

• See if an early-detection program reduces time to treatment for first-episode psychosis

  We test whether a large, region-wide early-detection program can shorten the time from first psychotic symptoms to treatment and help people function better later.

  Recruiting at 2 sites Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital · Copenhagen, Denmark and 1 other locations · NCT07716969

• Cerebellar imaging markers to predict antipsychotic response in first-episode psychosis

  This will test whether cerebellar brain scans can predict how people with first-episode psychosis respond to 12 weeks of treatment with risperidone or aripiprazole.

  Recruiting Phase 4 Northwell Health · Glen Oaks, New York · NCT07483294

• The Mouth Matters in Mental Health Trial –2

  This trial tests whether a link work program helps adults with severe mental illness to attend routine dental appointments and improves their oral health-related quality of life.

  Recruiting at 4 sites Lancashire Care NHS Foundation Trust · Preston, Lancashire and 4 other locations · NCT07470437

• Trying the Kiso Mind smartphone app for people with schizophrenia spectrum disorders

  This study tests whether the Kiso Mind smartphone app is acceptable, practical, and helpful for adults with schizophrenia or schizoaffective disorder alongside their usual care.

  Recruiting Charite University, Berlin, Germany · Berlin, State of Berlin · NCT07395206

• A smartphone mental health program for people with schizophrenia in West Africa

  This project will test whether two smartphone programs (FOCUS and a Ghana-adapted G-FOCUS) help outpatients with schizophrenia at Accra Psychiatric Hospital manage symptoms and daily life.

  Recruiting University of Washington · Accra · NCT07276321

• Cognitive Strategies in Early Psychosis 2 – how brain games and pills test decision making

  This study tests whether a single dose of modafinil or d-serine, compared with placebo, changes decision making in people aged 18–35 who have recently begun experiencing psychosis.

  Recruiting Phase 3 University of Minnesota · Minneapolis, Minnesota · NCT07263022

• Culturally adapted CBT for psychosis in Black people in the UK

  A small series tests whether culturally tailored cognitive-behavioral therapy for psychosis is doable, acceptable, and safe for Black Sub-Saharan African and Caribbean individuals in the UK.

  Recruiting University of Manchester · Manchester · NCT07252206

• Support program to help people with bipolar disorder transition from hospital to the community

  This pilot will try a combined program of group psychoeducation, one-on-one peer support, and clinician-focused help to see if it improves post-discharge outcomes for young adults (18–35) recently diagnosed with bipolar disorder who have had psychosis or limited illness insight.

  Recruiting McMaster University · Hamilton, Ontario · NCT07213492

• Precision brain stimulation to reduce cannabis craving in people with schizophrenia

  This trial tests whether targeted brain stimulation can reduce cannabis craving and improve thinking in people with schizophrenia who currently use cannabis.

  Recruiting Vanderbilt University Medical Center · Nashville, Tennessee · NCT07196462

• Thinking and brain chemistry in early psychosis

  This study will test whether a short session of gentle electrical brain stimulation changes glutamate levels and helps working memory and attention in people who recently experienced psychosis.

  Recruiting University of Nottingham · Nottingham, Nottinghamshire · NCT07196423

• Mentalization-Based Treatment for young people at clinical high risk for psychosis

  This project will test whether adding Mentalization-Based Treatment to usual need-based clinical care helps young people (ages 14–30) at high risk for psychosis reduce symptoms and avoid developing full psychosis.

  Recruiting Centre Hospitalier Universitaire Vaudois · Lausanne · NCT07093671

• Using exergames to support older adults with psychosis

  This project will test whether combining exergames with a falls-prevention program can help people aged 55 and older with psychosis improve mobility, thinking, and everyday functioning.

  Recruiting University Psychiatric Clinics Basel · Basel, Canton of Basel-City · NCT07060742

• Action-based cognitive remediation for alcohol and cannabis misuse in early psychosis

  This project will test whether action-based cognitive remediation helps young people with early psychosis cut down on alcohol and cannabis use.

  Recruiting at 2 sites Nova Scotia Health Authority · St. John's, Newfoundland and Labrador and 1 other locations · NCT07056894

• Predicting psychotic relapse using speech analysis

  This study is testing a new way to predict when people with early psychosis might have a relapse by analyzing their speech patterns to see if it can help them get support sooner.

  Recruiting at 3 sites Douglas Mental Health University Institute · London, Ontario and 2 other locations · NCT06978894

• Exploring social dysfunction in schizophrenia through brain activity

  This study is trying to see how brain activity during social interactions affects communication and social skills in people with schizophrenia.

  Recruiting Douglas Mental Health University Institute · Montreal, Quebec · NCT06978803

• Optimizing youth mental health trajectories

  This study is trying to understand how mental health changes in young people aged 9 to 25 over five years to see if we can help prevent problems like depression and ADHD.

  Recruiting Douglas Mental Health University Institute · Montreal, Quebec · NCT06978452

• Registry and biobank for neuroimmunological diseases

  This study is trying to see if certain antibodies in the brain are linked to neurological disorders like encephalopathy and psychosis, and how they might affect patients' health.

  Recruiting at 2 sites Charite University, Berlin, Germany · Berlin, State of Berlin and 1 other locations · NCT06958341

• KarXT plus KarX-EC for psychosis in Alzheimer's disease

  This trial tests whether taking KarXT together with KarX-EC can reduce hallucinations and delusions in people aged 55–90 with psychosis related to Alzheimer's disease.

  Recruiting at 3 sites Phase 3 Bristol-Myers Squibb · Gilbert, Arizona and 21 other locations · NCT06947941

• New blood test to help identify and track depression and early schizophrenia

  This project will try a new blood test to see if it can identify and track depression or early schizophrenia in adults receiving psychiatric care.

  Recruiting Fraser Health · New Westminster, British Columbia · NCT06856161

• Add CBD to antipsychotic treatment for first-episode psychosis to see if it helps more than placebo

  This study tests whether adding cannabidiol (CBD) to ongoing antipsychotic treatment helps people with a first episode of psychosis who haven’t fully responded to their first antipsychotic, compared with a placebo.

  Recruiting at 2 sites Phase 3 University of Oxford · Vienna and 16 other locations · NCT06778564

• Using probiotics to address weight gain from antipsychotic medications

  This study is testing whether a specific probiotic can help people with psychosis who are gaining weight from their antipsychotic medications.

  Recruiting at 2 sites University College Cork · Cork and 1 other locations · NCT06729671

• Using Virtual Reality and AI to Treat Psychosis

  This study is testing a new treatment that uses virtual reality and artificial intelligence to see if it can help people with psychosis feel better and improve their daily lives.

  Recruiting Oslo University Hospital · Oslo, Norway and 1 other locations · NCT06728241

• How the immune system affects response to antipsychotic medicines

  This study will test whether immune and inflammation markers in blood and cerebrospinal fluid can help predict or track treatment response in adults with psychosis who are starting or changing antipsychotic medication.

  Recruiting King's College London · London, United Kingdom · NCT06687694

• First-episode psychosis brain metabolism and antipsychotic effects

  This study tests how 4 to 6 weeks of antipsychotic medication affect brain metabolism in young adults with a first episode of psychosis.

  Recruiting Université de Sherbrooke · Sherbrooke, Quebec · NCT06651112

• Investigating the effects of clozapine on immune function in Parkinson's disease

  This study tests how clozapine affects the immune system in people with Parkinson's disease who have psychotic symptoms, to see if it increases their risk of infections.

  Recruiting Phase 4 Centre Hospitalier Universitaire, Amiens · Salouël · NCT06634641

• Seven-step phenomenological therapy for self-disorders in schizophrenia-spectrum conditions

  This pilot will try a seven-step psychotherapy to help adults with schizophrenia-spectrum disorders or early psychosis who experience disturbances in their sense of self.

  Recruiting Oslo University Hospital · Sandvika, Bærum and 1 other locations · NCT06597864

• Improving rehabilitation for veterans with serious mental illness

  This study is testing a new computer program to help veterans with serious mental illnesses improve their thinking and daily life skills.

  Recruiting VA Office of Research and Development · San Diego, California · NCT06586164

• Understanding how to treat individuals at high risk for psychosis

  This study is testing different treatments, like brain stimulation and mindfulness techniques, to see if they can help people who are at high risk of developing psychosis.

  Recruiting Beth Israel Deaconess Medical Center · Shanghai, Shanghai Municipality · NCT06542640

• A program to help young adults from minority groups engage with mental health services

  This study is testing a new program designed to help young adults from minority backgrounds connect better with mental health services by adding cultural insights and creative arts therapy.

  Recruiting New York University · The Bronx, New York · NCT06508450

• Using Lumateperone to improve motivation in patients with schizophrenia and psychosis

  This study is testing if Lumateperone can help people with schizophrenia or schizoaffective disorders feel more motivated and less apathetic.

  Recruiting Phase 3 Louisiana State University Health Sciences Center Shreveport · Shreveport, Louisiana · NCT06482554

• Non-invasive brain stimulation for improving apathy in schizophrenia

  This study is testing if a special type of brain stimulation can help reduce feelings of apathy in people with schizophrenia.

  Recruiting University of Geneva, Switzerland · Geneva and 1 other locations · NCT06341517

• Effect of Levetiracetam on Brain Function and Cognitive Performance in Psychosis Risk

  This study is testing if a single dose of levetiracetam can improve brain function and thinking skills in people at high risk for developing psychosis.

  Recruiting King's College London · London, London · NCT06224530

• Ketogenic diet and nutritional interventions for first episode bipolar disorder

  This study is testing if a ketogenic diet, along with regular treatment, can help people who are having their first episode of bipolar disorder or schizoaffective disorder feel better and improve their brain health.

  Recruiting Mclean Hospital · Belmont, Massachusetts · NCT06221852

• Nutritional counseling for patients with schizophrenia or bipolar disorder

  This study is testing whether nutritional counseling can help people with schizophrenia or bipolar disorder feel better over six weeks compared to those who don’t receive the counseling right away.

  Recruiting at 2 sites Vestre Viken Hospital Trust · Drammen, Akershus and 1 other locations · NCT06197048

• Personalized audio imagery with compact EEG to improve sleep for inpatients with psychosis

  This project tests whether individualized audio imagery delivered with compact EEG can improve sleep, psychosis symptoms, and suicidal thoughts in hospitalized patients with psychosis.

  Recruiting The University of Texas Health Science Center, Houston · Houston, Texas · NCT06194344

• Using magnetic stimulation to improve cognition in psychotic disorders

  This study is testing whether a type of brain stimulation called TMS can help improve thinking skills in people with psychotic disorders like schizophrenia and bipolar disorder.

  Recruiting at 2 sites Mclean Hospital · Belmont, Massachusetts and 1 other locations · NCT06107764

• Enhanced care for early psychosis treatment

  This study is testing whether a new, more supportive treatment for people experiencing their first episode of psychosis helps them stay engaged in their care better than standard treatment.

  Recruiting at 5 sites Mclean Hospital · Belmont, Massachusetts and 4 other locations · NCT06071858

• Trauma therapy for patients with PTSD and psychotic disorders

  This study is testing if a specific trauma therapy can help people with both PTSD and psychotic disorders feel better over time.

  Recruiting Medicalschool Hamburg · Hamburg · NCT06048172

• Exploring language disorders in patients with psychosis

  This study is trying to understand how language problems affect communication in people with psychosis, like schizophrenia, to see how these issues relate to their other symptoms.

  Recruiting Centre Psychothérapique de Nancy · Laxou, France · NCT06036316

• Assessing Brexpiprazole for Schizophrenia and Depression

  This study is testing how well brexpiprazole works and how easy it is to tolerate for adults with schizophrenia or depression who have just started taking the medication.

  Recruiting The University of Hong Kong · Hong Kong · NCT05962216

• Motivational Interviewing on acute psychosis wards to boost treatment adherence

  This pilot test on acute psychosis patients checks whether Motivational Interviewing helps patients stick with their treatment and strengthens the patient–therapist connection.

  Recruiting Psychiatric University Hospital, Zurich · Zurich, Canton of Zurich · NCT05911529

• Effects of exergaming on cognition in individuals with schizophrenia

  This study is testing if playing active video games can help improve thinking skills and reduce symptoms for people with schizophrenia.

  Recruiting Sykehuset i Vestfold HF · Tønsberg, Vestfold · NCT05858255

• Culturally adapted therapies for early psychosis in Pakistan

  This study is testing if specially adapted therapy programs can help people in Pakistan who are experiencing their first episode of psychosis feel better compared to standard treatment.

  Recruiting Pakistan Institute of Living and Learning · Karachi, Sindh · NCT05814913

• Personalized neuroprotective supplements plus cognitive training for people with early or high‑risk psychosis

  This trial tests whether adding tailored supplements (B12/folinic acid, omega‑3, NAC) and cognitive training to usual care improves functioning in adolescents and young adults with recent or high‑risk psychosis.

  Recruiting at 10 sites Phase 3 Centre Hospitalier St Anne · Brest and 12 other locations · NCT05796401

• Observational study on early stage psychosis and its mechanisms

  This study looks at people with early stage psychosis and those at risk for it, using brain scans and tests over five years to see how their brains work and what might cause their symptoms.

  Recruiting Uppsala University · Uppsala · NCT05763966

• Examining the effects of combined therapy for schizophrenia

  This study is testing whether combining two therapies, one for managing thoughts and another for improving cognitive skills, can help people with schizophrenia do better in their daily lives compared to using just one of the therapies.

  Recruiting at 2 sites University of Toronto · Scarborough Village, Ontario and 1 other locations · NCT05731414

• Examining the effects of combined therapy for schizophrenia

  This study is testing whether combining two therapies, one for managing thoughts and another for improving cognitive skills, can help people with schizophrenia do better in their daily lives compared to using just one of the therapies.

  Recruiting at 2 sites University of Toronto · Scarborough Village, Ontario and 1 other locations · NCT05731414

• Improving mental health care in West Africa using mobile health and nurse support

  This study is testing whether a new approach that combines nurse support and a mobile health app can improve mental health care for people with serious mental illnesses in Ghanaian prayer camps.

  Recruiting University of Washington · Accra · NCT05703711

• Exploring how social reward learning affects social pleasure in first-episode psychosis

  This study is testing whether different types of support can help young adults who have just experienced their first episode of psychosis feel more pleasure from social interactions.

  Recruiting at 2 sites University of Alabama at Birmingham · Birmingham, Alabama and 1 other locations · NCT05617898

• Maintenance rTMS for persistent auditory verbal hallucinations

  This trial tests whether adding regular maintenance rTMS sessions after a two-day intensive rTMS course can reduce persistent hearing voices in adults with schizophrenia or schizoaffective disorder.

  Recruiting University Hospital, Caen · Caen · NCT05550155

• Understanding the genetics and immune factors in youth with psychosis

  This study is testing the genes and immune systems of young people with psychosis to see if certain factors are linked to their symptoms and can help improve their diagnosis and treatment.

  Recruiting Rady Pediatric Genomics & Systems Medicine Institute · San Diego, California · NCT05457140

• Investigating cognitive function in psychosis patients and cannabis users

  This study is testing how taking a break from cannabis for 28 days affects thinking skills and brain activity in people with psychosis and those who use cannabis but don’t have mental health issues.

  Recruiting Douglas Mental Health University Institute · Montreal, Quebec · NCT05445180

• Reducing suicide risk in people with psychosis by targeting emotion regulation

  This study is testing a new therapy aimed at helping people with psychosis manage their emotions better to reduce their risk of suicide.

  Recruiting University of Maryland, Baltimore · Baltimore, Maryland · NCT05440214

• Intervention to reduce alcohol use in young people with early phase psychosis

  This study is testing a new therapy to see if it can help young people with early phase psychosis and alcohol problems improve their mental health and get back to school or work better than standard treatment.

  Recruiting Nova Scotia Health Authority · Halifax, Nova Scotia · NCT05365347

• Biomarkers linked to clozapine response in schizophrenia

  This project will test whether blood, spinal fluid, and brain scans can help predict which patients with treatment‑resistant schizophrenia will respond to clozapine.

  Recruiting Phase 4 Copenhagen University Hospital, Hvidovre · Glostrup Municipality, Denmark · NCT05316883

• Effects of Estradiol on Depression and Psychosis in Perimenopausal Women

  This study tests if giving estradiol to women aged 44-55 who are going through perimenopause can help improve their depression and psychosis symptoms.

  Recruiting Phase 4 University of North Carolina, Chapel Hill · Chapel Hill, North Carolina · NCT05282277

• Understanding social cognition deficits in autism and psychosis

  This study is testing how a social skills program can help improve social understanding in teenagers with autism and those with schizophrenia, while also looking at how their brains work differently.

  Recruiting Loma Linda University · Loma Linda, California · NCT05185128

• Improving social functioning and reducing psychosis risk through cognitive training

  This study is testing a 10-week program to see if cognitive training can help teenagers at risk for psychosis improve their thinking skills and social interactions.

  Recruiting Northwell Health · Glen Oaks, New York · NCT05131035

• Digital tool for identifying young people at risk of psychosis

  This study is testing a new online tool to help find young people aged 12-35 who might be at risk of developing psychosis so they can get early support.

  Recruiting at 2 sites King's College London · Glasgow and 1 other locations · NCT05127278

• Evaluation of the redevelopment of Ireland's National Forensic Mental Health Service

  This study is testing how moving to a new 170-bed mental health hospital in Ireland affects the recovery and care of patients with mental health issues involved in the justice system.

  Recruiting Health Service Executive, Ireland · Dublin · NCT05074732

• Investigating the links between social isolation, loneliness, and mental illness

  This study is trying to see how feeling lonely and isolated affects people with serious mental illnesses like schizophrenia and psychosis, using brain scans and smartphone tools to understand their daily experiences.

  Recruiting Massachusetts General Hospital · Charlestown, Massachusetts · NCT04940663

• Using memantine to improve negative symptoms in first-episode psychosis

  This study is testing if adding memantine to regular antipsychotic treatment can help people experiencing their first episode of psychosis feel better by reducing negative symptoms like lack of pleasure and social withdrawal.

  Recruiting Phase 1 University of Copenhagen · Glostrup Municipality, Capitol Region · NCT04789915

• Personalized treatment approach for auditory hallucinations

  This study is testing a new personalized treatment for people with psychotic disorders who hear voices and haven't found relief with regular medications.

  Recruiting Early Phase 1 Yale University · New Haven, Connecticut · NCT04366518

• Genetic counselling to prevent mental health issues from cannabis use

  This study is trying to see if genetic counselling can help young people aged 12 to 21 understand their risk of mental health issues from cannabis use and make better choices about using it.

  Recruiting Nova Scotia Health Authority · Halifax, Nova Scotia · NCT03601026

• Analyzing speech to predict psychosis in at-risk patients

  This study is trying to see if analyzing the way people at high risk for schizophrenia speak can help predict if they will develop psychosis.

  Recruiting at 2 sites University Hospital, Brest · Brest and 2 other locations · NCT03525054

NIH-funded research (newest 40 of 243)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Psychosis in diverse settings across the world

  This project studies how psychotic disorders show up and respond to treatment in adults with diverse backgrounds, including populations in Africa, the Caribbean, and other Global South settings.

  NIH research Suny Downstate Medical Center · Brooklyn, United States · NIH-11592428

• Psychosis in Diverse Settings: Understanding Symptoms and Treatment Across Global South

  A human-facing study will look at how psychotic disorders present and respond to treatment in adults from Africa, the Caribbean, and other Global South settings, using genetic and clinical data.

  NIH research Suny Downstate Medical Center · Brooklyn, United States · NIH-11592427

• A new online brain-scan-style tool to spot early psychosis risk

  A new online-based set of tasks and a computer model aims to identify people at high risk for developing psychosis earlier and more accurately.

  NIH research Northwestern University · Chicago, United States · NIH-11590585

• Genetic clues for early-onset psychosis in Latino youth

  This project looks at the genes of young people with early-onset psychosis and compares them with similar youths without psychosis to find genetic factors that contribute to the illness.

  NIH research Boston Children's Hospital · Boston, United States · NIH-11554752

• Biomarkers to tailor rehab for Veterans with schizophrenia

  A clinician-scientist is developing a brain-based biomarker to guide personalized rehabilitation for Veterans with schizophrenia.

  NIH research VA San Diego Healthcare System · San Diego, United States · NIH-11552825

• Computational analysis of facial expression in early psychosis

  Aims to develop computer-based measures of facial expression in people at risk for or with schizophrenia to help track symptoms and guide future trials.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11539126

• Mental Wellness Coordinated Care for Young People with Untreated Psychosis in Mozambique

  A program in Mozambique aims to bring early, coordinated care for adolescents and young adults with new psychosis, using evidence-based services to reduce symptoms and improve functioning.

  NIH research New York State Psychiatric Institute Dba Research Foundation for Mental Hygiene, INC · New York, United States · NIH-11535217

• Predicting outcomes in teens at high risk for psychosis (PRESCIENT)

  This project follows teens at high risk for psychosis to build better tools that predict who may develop psychosis or related outcomes.

  NIH research University of Melbourne · Melbourne, Australia · NIH-11528615

• PRESCIENT: Predicting Psychosis risk in High-Risk Youth

  This project aims to improve early prediction of psychosis in teens and young adults at high risk using multiple biomarkers and clinical data to guide prevention.

  NIH research University of Melbourne · Melbourne, Australia · NIH-11528614

• Predicting psychosis risk in teens using multiple biomarkers and data

  This project looks at teens at high risk for psychosis and uses multiple health data pieces to predict who might develop serious symptoms.

  NIH research University of Melbourne · Melbourne, Australia · NIH-11528613

• PRESCIENT: Predicting outcomes in teens at high risk for psychosis

  A large international study is tracking teens at risk for psychosis to create and test ways to predict who may develop psychosis and how they’ll fare over time.

  NIH research University of Melbourne · Melbourne, Australia · NIH-11528612

• Predicting psychosis risk in teens at high risk (PRESCIENT)

  A study helps teens who are at high risk for developing psychosis by building better ways to predict who might need early help.

  NIH research University of Melbourne · Melbourne, Australia · NIH-11528611

• Predicting Psychosis Risk in Young People (PRESCIENT)

  A study to help identify which teens and young adults at high risk for psychosis are most likely to develop serious symptoms, using multiple brain and clinical markers.

  NIH research University of Melbourne · Melbourne, Australia · NIH-11528610

• PRESCIENT: Predicting Psychosis Risk in Adolescents

  A long-term study in teens at risk for psychosis uses biomarkers and clinical data to predict who may develop psychosis or related outcomes.

  NIH research University of Melbourne · Melbourne, Australia · NIH-11528609

• PREDICT: Data and AI tools to study psychosis risk in youth

  A national effort uses big data and smart computer tools to find new clues that predict psychosis risk in children and teens who show early signs.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11527266

• PREMAP: Predictors of Menopause-Related Psychosis

  A study to understand what factors predict psychosis that can occur during menopause, with a focus on women going through that transition.

  NIH research Yale University · New Haven, United States · NIH-11520455

• Supported Employment to Help Youth with Early Psychosis in Uganda

  A patient-facing plan to help young people in Uganda with early psychosis find and keep jobs through an adapted IPS program.

  NIH research New York State Psychiatric Institute Dba Research Foundation for Mental Hygiene, INC · New York, United States · NIH-11519495

• PREDICT: Data-driven tools to understand and coordinate early psychosis risk in youth

  Aciient-style data platform and analysis center will combine big datasets and AI methods to improve how we predict and study early signs of psychosis in children and adolescents.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11519474

• ProNET: Psychosis-Risk Outcomes Network

  A network study following people at high risk for psychosis to understand brain, behavior, and biology and how these relate to outcomes over two years.

  NIH research Yale University · New Haven, United States · NIH-11519473

• PRESCIENT: predicting outcomes in teens at risk for psychosis

  A large international effort is building and testing models to predict who among 12- to 20-year-olds at high risk for psychosis will experience meaningful health outcomes.

  NIH research University of Melbourne · Melbourne, Australia · NIH-11514522

• Cognitive Behavioral Therapy for Insomnia to Help Veterans with Psychosis

  A veteran-focused CBT-I program tailored for those with psychosis aims to improve sleep and daily functioning.

  NIH research Baltimore VA Medical Center · Baltimore, United States · NIH-11511695

• ProNET: Understanding early risk for psychosis

  This project follows people showing early signs of psychosis risk to collect brain scans, EEG, blood tests, speech samples, and phone data that could help predict who develops psychosis.

  NIH research Yale University · New Haven, United States · NIH-11493636

• Psychosis-risk Outcomes Network (ProNET)

  This project follows people at clinical high risk for psychosis across many centers to link brain, genetic, biological, and smartphone-based signals with symptom courses over two years.

  NIH research Yale University · New Haven, United States · NIH-11493635

• Understanding and tracking early signs of psychosis

  This project follows people with early warning signs of psychosis to find brain, behavioral, genetic, and digital markers that help predict future outcomes.

  NIH research Yale University · New Haven, United States · NIH-11493634

• Network to understand early signs and outcomes in people at high risk for psychosis

  This project will collect brain scans, EEG, genetics, blood tests, speech samples and smartphone data from people at clinical high risk for psychosis to find patterns that predict who develops psychosis over two years.

  NIH research Yale University · New Haven, United States · NIH-11493633

• Network to understand early signs of psychosis

  This network follows people at clinical high risk for psychosis and healthy volunteers to look for brain, speech, blood, genetic, and smartphone signals that predict who develops psychotic disorders.

  NIH research Yale University · New Haven, United States · NIH-11493632

• Preventing psychosis in people at high risk

  Using brain scans, genetics, blood tests, speech samples, and smartphone data to predict outcomes and guide care for people with early signs of psychosis.

  NIH research Yale University · New Haven, United States · NIH-11493631

• Psychosis Risk Outcomes Network

  This project follows people at high risk for psychosis and collects brain scans, blood tests, speech samples, and smartphone data to find signs that predict future symptoms.

  NIH research Yale University · New Haven, United States · NIH-11493630

• ProNET — a network tracking early signs of psychosis

  This project follows people at clinical high risk for psychosis over two years using brain scans, tests, and smartphone data to find patterns that predict clinical outcomes.

  NIH research Yale University · New Haven, United States · NIH-11491101

• Social Cognition Measures for People at Risk of Psychosis

  A study to find and test the best mental tasks that measure social thinking for people who might develop psychosis.

  NIH research University of Texas Dallas · Richardson, United States · NIH-11468905

• Comparing Medicines for a First Episode of Psychosis

  A study looking at how different antipsychotic medicines work for teens and adults when they first develop psychosis, with a focus on sticking to the treatment.

  NIH research Mclean Hospital · Belmont, United States · NIH-11419764

• Laboratory for Early Psychosis Research (LEAP) Center for Early Intervention

  A nationwide program in Massachusetts aims to improve how first-episode psychosis is treated by testing new care approaches and using data to guide decisions.

  NIH research Mclean Hospital · Belmont, United States · NIH-11419731

• Biomarkers and Biotypes to Predict Early Psychosis Outcomes in Bipolar Disorder

  This study uses brain-related biomarkers and clinical data to predict how early psychosis will progress in people with bipolar disorder undergoing specialized care.

  NIH research Beth Israel Deaconess Medical Center · Boston, United States · NIH-11417173

• Biomarkers and Biotypes in Early Psychosis for Bipolar Disorder and Related Conditions

  This project uses biomarker-based brain patterns and clinical data to predict outcomes for people with early psychosis and bipolar disorder who receive specialized care.

  NIH research Yale University · New Haven, United States · NIH-11417147

• Biomarkers and Biotypes to Predict Early Psychosis Course in Bipolar Disorder

  Researchers will use brain and cognitive markers to help predict how early psychosis in bipolar disorder patients will progress and what treatments might help best.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11412655

• Biomarkers and Biotypes to Predict Early Psychosis Outcomes in Bipolar Disorder and Related Conditions

  Aiming to use brain and cognitive biomarkers to predict how young people with early psychosis will fare over the first year of care.

  NIH research University of Georgia · Athens, United States · NIH-11412635

• Biomarkers and Early Psychosis Trajectories in Bipolar Disorder and Related Conditions

  This grant tests whether biomarker-based groups can predict how young people with early psychosis will fare in coordinated specialty care to tailor treatment.

  NIH research University of Chicago · Chicago, United States · NIH-11408526

• Neurodevelopment and Psychosis in 22q11.2 Deletion Syndrome

  A long-term study follows people with 22q11.2 deletions to understand how genetic risk leads to brain and behavior changes over time, with the goal of identifying early clues for psychosis.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11404798

• Early Psychosis Intervention Network data center improves coordinated care

  A national data center powered by Westat will standardize and share information from dozens of early psychosis programs to help doctors better understand and treat people with early signs of psychosis.

  NIH research Westat, INC. · Bethesda, UNITED STATES · NIH-11398982

• Predicting Psychosis Outcomes from Electronic Health Records

  A next-step project uses computer models to help doctors forecast how psychosis-related conditions may unfold for patients using routine health records.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11395522

Related topics

Quick answers

How many Psychosis clinical trials are recruiting right now?

68, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 22 countries. The most sites are in United States (21 trials), Canada (13 trials), United Kingdom (8 trials), France (5 trials), Switzerland (5 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 5, Phase 4: 4, Phase 1: 1, Early Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

Describe your situation →