Condition

Bipolar Depression clinical trials and research

• 20Clinical trials
• 3NIH research projects
• 16Countries

Newest Bipolar Depression clinical trials

All recruiting trials (20)

• SCC Deep Brain Stimulation for Bipolar Depression in Bipolar I Patients

  A small study tests whether deep brain stimulation of the subcallosal cingulate can help people with bipolar I depression who have not improved with other treatments, while monitoring brain signals to watch for manic switches.

  Recruiting Icahn School of Medicine at Mount Sinai · New York, New York · NCT07745374

• EEG microstates and inflammatory biomarkers in older adults with major depression receiving ECT

  This study tests how ECT affects brain wave patterns and inflammatory markers in people 55 and older with major depression.

  Recruiting Istanbul University - Cerrahpasa · Istanbul, Bakırköy · NCT07740694

• RNA editing to predict antidepressant response in unipolar and bipolar depression

  This project tests whether changes in RNA editing can predict how adults with unipolar or bipolar depression respond to antidepressant treatment.

  Recruiting Phase 4 Mayo Clinic · Rochester, Minnesota · NCT07266545

• High-definition tDCS targeting the primary somatosensory cortex for adolescent bipolar depression

  This trial will try high-definition transcranial direct current stimulation (HD-tDCS) to reduce depressive symptoms in adolescents aged 12–18 with bipolar depression, compared with a sham procedure.

  Recruiting Jiangsu Province Nanjing Brain Hospital · Nanjing, Jiangsu · NCT07246044

• Ketogenic diet for bipolar depression

  This study will try a high-fat, very low-carbohydrate (ketogenic) diet to see if it helps adults aged 18–50 with bipolar depression.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07121894

• MR-guided focused ultrasound bilateral capsulotomy for refractory bipolar depression

  This will try MR-guided focused ultrasound capsulotomy to see if it helps adults with treatment-resistant bipolar depression.

  Recruiting Sunnybrook Health Sciences Centre · Toronto, Ontario · NCT07108257

• Temporal interference stimulation for bipolar depression

  This trial will test whether temporal interference brain stimulation can help adults with bipolar depression and uses MRI and EEG to see how the brain responds.

  Recruiting First Affiliated Hospital of Zhejiang University · Hangzhou, Zhejiang · NCT07021508

• Deep Brain Stimulation for Severe Bipolar Depression

  This study is testing whether Deep Brain Stimulation can help people with severe bipolar depression who haven't found relief from other treatments.

  Recruiting Baylor College of Medicine · Boston, Massachusetts and 3 other locations · NCT06599099

• Synchronized eating for bipolar depression

  This trial will test whether limiting eating to a 10-hour daily window plus usual care helps adults aged 18–55 with bipolar depression compared with nutritional counselling plus usual care.

  Recruiting University of Ottawa · Ottawa, Ontario · NCT06560957

• Using deep transcranial magnetic stimulation to treat bipolar depression

  This study is testing if deep transcranial magnetic stimulation can help people with bipolar depression feel better when added to their current treatment.

  Recruiting Tianjin Anding Hospital · Tianjin · NCT06524505

• Program to lower cardiovascular risk with a nutrition plan for people with bipolar disorder

  This trial will test whether a dietary program based on the Brazilian Dietary Guidelines can lower cardiovascular risk in adults with bipolar disorder who are on stable medication.

  Recruiting University of Sao Paulo · São Paulo, São Paulo · NCT06488573

• Non-invasive brain-computer interface for people with depression

  This study is testing a new brain-computer interface to see if it can help understand depression better by looking at brain and blood changes in people with Major Depressive Disorder.

  Recruiting Phase 4 Shanghai Mental Health Center · Shanghai, Shanghai Municipality · NCT06417437

• Treatment of Bipolar Depression in Children with Lumateperone

  This study is testing if a new medication called lumateperone can help children and teens aged 10 to 17 who are struggling with depression related to bipolar disorder feel better.

  Recruiting at 37 sites Phase 3 Intra-Cellular Therapies, Inc. · Dothan, Alabama and 67 other locations · NCT06372964

• Using theta-burst stimulation to treat bipolar depression

  This study is testing if a new brain stimulation technique can help people with bipolar disorder who haven't found relief from their depression.

  Recruiting at 2 sites Centre for Addiction and Mental Health · Toronto, Ontario and 1 other locations · NCT06370988

• Effects of exercise and ibuprofen on bipolar depression symptoms

  This study tests if exercising while taking ibuprofen can help improve mood in people aged 18-55 who have bipolar depression.

  Recruiting Phase 1/2 Laureate Institute for Brain Research, Inc. · Tulsa, Oklahoma · NCT06088732

• Behavioral Activation for treating Bipolar Depression

  This study is testing a new therapy called Behavioral Activation to see if it can help people with Bipolar Disorder who are feeling depressed by encouraging healthier activities and better sleep.

  Recruiting Reykjavik University · Reykjavik · NCT06022913

• Intensified treatment for bipolar depression after first treatment failure

  This study is testing a stronger six-week medication plan for people with bipolar depression who didn't get better with their first treatment to see if it works better than the usual approach.

  Recruiting at 11 sites Phase 3 UMC Utrecht · Innsbruck and 12 other locations · NCT05973786

• Investigating OSU6162 for treating bipolar depression

  This study is testing a new treatment called OSU6162 to see if it helps people with bipolar depression feel better during a tough depressive episode while they are on stable mood medication.

  Recruiting Phase 2 Göteborg University · Gothenburg · NCT05296356

• Brexpiprazole for treating depression in bipolar disorder

  This study is testing if adding Brexpiprazole to the treatment plan can help adults with bipolar disorder who are still feeling depressed after trying other medications.

  Recruiting Phase 3 Douglas Mental Health University Institute · Hamilton, Ontario and 2 other locations · NCT04569448

• Registry for patients with treatment-resistant depression and OCD receiving interventional therapies

  This study is testing different treatments like ECT, TMS, and ketamine to see how they help people with treatment-resistant depression and OCD feel better.

  Recruiting University of Iowa · Iowa City, Iowa · NCT04480918

NIH-funded research (3)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Mood-state classifiers to guide brain stimulation for treatment-resistant bipolar depression

  This project tests a brain stimulation therapy combined with wearable and smartphone data to help people with treatment-resistant bipolar depression regain mood stability.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11392518

• Brain implants and wearables to monitor and help severe bipolar depression

  This project uses an implanted brain stimulator together with phone and wearable data to detect mood patterns and help people whose bipolar depression hasn't responded to other treatments.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11178411

• Using brain stimulation to improve mood in patients with treatment-resistant bipolar depression

  This study is looking at how deep brain stimulation can help people with bipolar depression who haven't found relief from other treatments, using a smartphone app to track their moods in real-time and make adjustments to their care as needed.

  NIH research Baylor College of Medicine · Houston, United States · NIH-10872038

Related topics

Quick answers

How many Bipolar Depression clinical trials are recruiting right now?

20, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 16 countries. The most sites are in United States (7 trials), China (4 trials), Canada (4 trials), Austria (1 trial), Germany (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 3, Phase 4: 2, Phase 1/2: 1, Phase 2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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