Premorbid Personality Profile in bvFTD, phFTD, frontal AD, and bipolar disorder

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study explores how premorbid personality traits relate to current cognitive and behavioral/psychobehavioral symptoms in patients with frontal-region disorders. Participants complete the NEO-PI-3 to capture prior personality profiles and the Interpersonal Reactivity Index to assess empathy-related traits. The goal is to see if early personality factors are linked to how these conditions manifest clinically, alongside caregiver input. Eligible groups include bvFTD, phFTD, frontal AD, and bipolar disorder with frontal involvement, with a caregiver available for collaboration. Data from Nantes University Hospital will inform whether premorbid traits contribute to disease expression across these conditions.

Why it matters

Who can join: the full rules

Inclusion Criteria :

* Patients with behavioral variant of frontotemporal disorder (bvFTD) according to Rascovsky criteria (2011) or patients with phénocopy frontotemporal dementia (phFTD) who fulfill criteria for possible bvFTD and have no imaging abnormalities or patients with frontal variant of Alzheimer disease according to Ossenkopele criteria (2022), or patient with bipolar disorder according to CIM 10 criteria
* Score for Mini-mental state examination ≥ 18
* Patient with caregiver who has who has known him/her in the 10 years preceding the disease onset.
* Patient and caregiver consents (no opposition)

Exclusion Criteria :

* Patient with no caregiver
* Pregnant or breast feeding women

Where it's running

• CHU de Nantes
  Nantes, France Recruiting

Study contacts

• Study coordinator: Claire BOUTOLEAU-BRETONNIERE, PH
• Email: claire.boutoleaubretonniere@chu-nantes.fr
• Phone: 33 2 40 16 54 22

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.