Clinical trial Recruiting at 1 site Observational Ages 18 to 65

Effects of comorbidity on people with severe mental illness

Official title: The Effect of Comorbid Alcohol/Substance Use on Social Inclusion and Clinical Outcome in Individuals With Severe Mental Illness Enrolled in a Community Mental Health Center: A Cross-Sectional Case-Control Study

Run by Abant Izzet Baysal University · NCT07692984 · Data updated 2026-11-12

This study tests how having both alcohol/substance use and a severe mental illness affects hospitalizations, medications, and social participation among adults followed at a mental health center.

Quick facts

Study typeObservational
Ages18 Years to 65 Years
SexAll
Enrollment297 (estimated)
SponsorAbant Izzet Baysal University
Academic / other
Locations1 site (Bolu, Bolu)
StatusRecruiting
StartedJune 20, 2026
Main results expectedSeptember 30, 2026
Study endsDecember 30, 2026
Registry record updatedJuly 13, 2026
Trial IDNCT07692984 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults (18+) with schizophrenia spectrum or bipolar disorder, actively followed at the Bolu Mental Health and Diseases Rehabilitation Center for at least 6 months, with or without ASUD.

Probably not a fit

Individuals without comorbid ASUD or those not meeting the follow-up requirement may not demonstrate a difference.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a cross-sectional, case-control study conducted at a community mental health center. It compares patients with severe mental illness who also have alcohol and/or substance use disorders to matched patients without substance use, looking at clinical course and social inclusion. Data collected include demographics, diagnoses, hospitalizations, medication dosages, employment, and social functioning. No interventions are applied; the study observes existing conditions and histories. Eligibility includes adults 18 and over with schizophrenia spectrum or bipolar disorder, followed at the center for at least 6 months.

Why it matters

Potential benefit: If successful, findings could clarify how comorbidity relates to treatment needs and social outcomes for people with severe mental illness.

How similar studies have gone: Previous research in similar populations has explored comorbidity effects, but this study adds a targeted, cross-sectional, matched-control approach in a Turkish mental health center.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Being 18 years of age or older,
* Having a diagnosis of Schizophrenia Spectrum Disorder and Other Psychotic Disorders or Bipolar Disorder according to DSM-5 diagnostic criteria,
* Being actively followed up at the TRSM for at least 6 months.

Exclusion Criteria:

* Individuals diagnosed with organic brain damage or neurodevelopmental disorders (intellectual disability, etc.),
* Individuals with severe cognitive impairment that prevents them from communicating adequately.

Where it's running

  • Melisa Bulut
    Bolu, Bolu, Turkey (Türkiye)
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.