Cerebellar stimulation to improve cognitive function and mood
Official title: Cerebellar Transcranial Magnetic Stimulation and Cognitive Control
Run by University of Iowa · NCT03217110 · Data updated 2026-11-12
This study is testing if a special brain stimulation can help improve thinking and mood in people with schizophrenia, autism, bipolar disorder, and Parkinson's disease.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 90 Years |
| Sex | All |
| Enrollment | 200 (estimated) |
| Sponsor | University of Iowa Academic / other |
| Locations | 1 site (Iowa City, Iowa) |
| Status | Recruiting |
| Started | November 30, 2017 |
| Main results expected | December 1, 2028 |
| Study ends | December 1, 2028 |
| Registry record updated | March 19, 2026 |
| Trial ID | NCT03217110 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include individuals diagnosed with schizophrenia, autism spectrum disorder, bipolar disorder, or Parkinson's disease.
✕Probably not a fit
Patients with a history of recurrent seizures, other significant neurological or psychiatric disorders, or those who are pregnant or breastfeeding may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates the use of cerebellar stimulation to enhance cognitive deficits and mood in patients with schizophrenia, autism spectrum disorder, bipolar disorder, and Parkinson's disease. Participants will undergo repetitive transcranial magnetic stimulation (rTMS) or sham stimulation over 5 to 6 visits, with cognitive, emotional, and EEG assessments conducted throughout. The goal is to determine if modulating cerebellar activity can restore frontal brain function and improve cognitive outcomes. The study aims to provide insights into the cerebellum's role in cognitive control and emotional regulation.
Why it matters
Potential benefit: If successful, this approach could lead to new treatment options for improving cognitive function and mood in patients with various neurological and psychiatric conditions.
How similar studies have gone: While the approach of using cerebellar stimulation is relatively novel, previous studies have shown promise in using transcranial magnetic stimulation for cognitive enhancement in similar populations.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * A clinical diagnosis consistent with enrollment Exclusion Criteria: * History of recurrent seizures or epilepsy * Any other neurological or psychiatric diagnosis outside the diagnosis for which the participant is enrolled. * Active substance use disorder in the past 6 months other than tobacco use disorder. * Inability to consent for study. * Pacemaker * Coronary Stent * Defibrillator * Neurostimulation * Claustrophobia * Uncontrolled high blood pressure * Atrial fibrillation * Significant heart disease * Hemodynamic instability * Kidney disease * Pregnant, trying to become pregnant, or breast feeding
Where it's running
-
University of Iowa
Iowa City, Iowa, United States Recruiting
Study contacts
- Principal investigator: Krystal L Parker, Ph.D — Univeristy of Iowa
- Study coordinator: Krystal L Parker, Ph.D
- Email: CT201610712@gmail.com
- Phone: 319-353-4554
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Compassion-focused therapy for reducing self-stigma in mental health disorders
This study is testing whether Compassion Focused Therapy can help people with mental health disorders feel better about themselves and reduce feelings of shame.
-
Assessing the safety of lumateperone in young patients with schizophrenia or bipolar disorder
This study is testing if lumateperone is safe for young people with schizophrenia or bipolar disorder who will take the medication daily for 26 weeks.
-
Culturally tailored nurse-led COPE program for caregivers of children with autism
This study tests a culturally adapted COPE program led by nurses to help primary caregivers of children with autism feel less distressed, alongside standard care.
-
Effects of comorbidity on people with severe mental illness
This study tests how having both alcohol/substance use and a severe mental illness affects hospitalizations, medications, and social participation among adults followed at a mental health center.
-
Venous Tourniquet with Low-Dose Sugammadex vs Arterial Tourniquet for Seizure Monitoring During ECT
40 patients undergoing ECT will have a venous tourniquet on one arm and an arterial tourniquet on the other to see which method better reveals motor seizures.
-
7T MRI and visual perception markers for severe mood and psychotic disorders
This project tests whether 7‑tesla MRI scans combined with visual perception tests can identify brain markers linked to diagnosis and treatment outcomes in adults with major depressive disorder, bipolar disorder, or schizophrenia.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.