Personalized mobile app for cognitive behavioral therapy

Efficacy of Personalized Mobile Cognitive Behavioral Therapy Targeting Anxiety and Depression

Not applicable Interventional Weill Medical College of Cornell University · NCT05699525

This study is testing if a personalized mobile app for cognitive behavioral therapy can help young people with anxiety, depression, or bipolar disorder just as much as a standard app.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment100 (estimated)
Ages18 Years to 25 Years
SexAll
SponsorWeill Medical College of Cornell University Academic / other
Locations1 site (New York, New York)
Trial IDNCT05699525 on ClinicalTrials.gov

What this trial studies

This study compares the effectiveness of a standard mobile cognitive behavioral therapy (CBT) program with a personalized version tailored to individual symptom profiles for adolescents and young adults experiencing anxiety, depression, or bipolar disorder. Participants will use the Maya app for two days a week over six weeks, engaging in assessments and optional MRI and EEG recordings. The goal is to determine if the personalized approach is as effective as the standard program while being less burdensome. The study aims to optimize mental health interventions that are easily accessible to young individuals.

Who should consider this trial

Good fit: Ideal candidates are adolescents and young adults aged 18 to 25 with a primary diagnosis of anxiety, depression, or bipolar disorder.

Not a fit: Patients with a history of psychotic disorders, current manic episodes, or those already receiving cognitive behavioral therapy may not benefit from this study.

Why it matters

Potential benefit: If successful, this approach could provide a more effective and accessible mental health intervention for young people struggling with anxiety and mood disorders.

How similar studies have performed: Other studies have shown promise in using mobile applications for mental health interventions, suggesting potential success for this personalized approach.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Age between 18 and 25 years.
* Primary diagnosis of an anxiety, depressive, or bipolar disorder as determined by a score of 4 or greater on the Clinical Severity Rating of the Anxiety Disorders Interview Schedule (ADIS).
* If an individual is diagnosed with bipolar disorder, they must be currently euthymic or experiencing a depressive episode.
* Access to an Apple iPhone, iPad, or Android device

Exclusion Criteria:

* History of neurologic disorder that may affect the neural systems of interest or participant's ability to participate
* Lifetime diagnosis of a psychotic disorder.
* Current hypomanic or manic episode.
* Currently in cognitive behavior therapy.
* Change in dose of a psychiatric medication in the past 12 weeks.
* Initiation of psychotherapy in the past 12 weeks.
* Intent or plan to attempt suicide.

Where this trial is running

New York, New York

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Anxiety Disorders and SymptomsDepressionBipolar DisorderSymptoms
Last reviewed 2026-06-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.