Understanding how the brain processes information in bipolar disorder
Official title: Establishing Network Neuroscience Mechanisms of Efficiency of Evidence Accumulation in a Well-Characterized Sample with Bipolar Disorder: A Multi-Modal Clinical Imaging Study
Funded at University of Michigan at Ann Arbor · NIH-11064023 · Data updated 2026-11-12
This study is looking at how the brains of people with bipolar disorder gather information and make choices, and it will compare their brain activity to that of healthy individuals to see what differences exist.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | June 1, 2022 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $614,346 |
| NIH project number | 5R01MH130348-04 |
| Project ID | NIH-11064023 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 21 and older who have been diagnosed with bipolar disorder.
✕Less likely to help
Patients who do not have bipolar disorder or are under 21 years old may not benefit from this research.
What this research studies
This research investigates the brain mechanisms that affect how individuals with bipolar disorder accumulate information and make decisions. By using advanced imaging techniques and computational models, the study aims to identify how the brain's network connectivity influences this cognitive process. The research will involve comparing brain activity in adults with bipolar disorder to that of healthy adults to uncover differences in information processing. Participants will be part of a well-characterized sample from the Prechter Longitudinal Study of Bipolar Disorder.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment strategies for bipolar disorder by targeting cognitive deficits.
How similar studies have gone: Previous research has shown promising results in understanding cognitive processes in psychiatric disorders using similar network neuroscience approaches.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Sripada, Chandra Sekhar — University of Michigan at Ann Arbor
- Study coordinator: Sripada, Chandra Sekhar
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.