Condition

Alcohol Use Disorder clinical trials and research

• 138Clinical trials
• 259NIH research projects
• 1New in 30 days
• 19Countries

Newest Alcohol Use Disorder clinical trials

All recruiting trials (138)

• Emotional Reactivity in Severe Alcohol Use Disorder and Depression Using Eye-Tracking and Physiological Measures

  This study tests how people with severe alcohol use disorder, major depressive disorder, both conditions, or neither, recognize and react to emotions using eye-tracking and physiological data.

  Recruiting Université Catholique de Louvain · Brussels, Belgium · NCT07925281

• Thiamine to reduce brain injury in adults with alcohol use disorder

  This trial tests whether thiamine can help protect the brain in adults with moderate to severe alcohol use disorder who drink daily.

  Recruiting Phase 2 Institut National de la Santé Et de la Recherche Médicale, France · Paris, Île-de-France Region · NCT07844720

• Digital Recovery Support for Black adults with Alcohol Use Disorder in Detroit

  This study tests whether a smartphone-based digital recovery program helps Black or African American adults in Detroit maintain their recovery from alcohol use disorder.

  Recruiting Brandeis University · Detroit, Michigan · NCT07724275

• Path180: a computer-based skills program to help teens reduce alcohol use

  This 8-week trial tests Path180, a computer-based skills training, added to usual care for teens 13–19 with alcohol use disorder to see if it improves daily-life coping skills and outcomes.

  Recruiting Brown University · Providence, Rhode Island · NCT07713251

• Effects of comorbidity on people with severe mental illness

  This study tests how having both alcohol/substance use and a severe mental illness affects hospitalizations, medications, and social participation among adults followed at a mental health center.

  Recruiting Abant Izzet Baysal University · Bolu, Bolu · NCT07692984

• Psilocybin in Alcohol Use Disorder with Depression (Relapse Prevention)

  This study tests whether higher-dose psilocybin-assisted psychotherapy helps prevent relapse in adults with severe alcohol use disorder and depressive symptoms after detox.

  Recruiting Phase 3 Centre Hospitalier Universitaire de Nīmes · Bayonne and 7 other locations · NCT07638553

• Liver health check plus brief alcohol support for hospitalized adults

  In hospitalized adults who drink harmfully, doctors will test liver stiffness and offer personalized brief alcohol advice to see if it helps reduce drinking compared with usual care.

  Recruiting Oslo University Hospital · Bergen and 7 other locations · NCT07637539

• Imaging brain stress systems in people with heavy drinking to see if cortisol boosts NOP signals

  In people with heavy drinking, this PET study tests whether hydrocortisone increases NOP receptor binding more than in healthy controls, to see if this relates to relapse risk.

  Recruiting Early Phase 1 University of Pittsburgh · Pittsburgh, Pennsylvania · NCT07612631

• Ketogenic Diet and Alcohol Intoxication: Can ketosis affect brain function and alcohol response

  This study tests whether a 4‑week ketogenic diet changes how the brain works and how the body handles alcohol in adults who drink regularly.

  Recruiting University of Pennsylvania · Philadelphia, Pennsylvania · NCT07602270

• Optimizing Smart Messaging for Alcohol Recovery

  A smartphone-based program tests whether tailored recovery messages can help people with alcohol use disorder stay engaged with support resources and improve health outcomes.

  Recruiting University of Wisconsin, Madison · Madison, Wisconsin · NCT07573540

• Integrating medications and brief counseling for alcohol use disorder into hepatology clinics

  This project will test a way to help hepatology clinic clinicians provide medicines and short counseling for people with alcohol use disorder and alcohol-associated liver disease.

  Recruiting Yale University · New Haven, Connecticut · NCT07525258

• NTX-2001 for reducing alcohol use in adults with alcohol use disorder

  This study will test whether NTX-2001, a TAAR1 partial agonist, can reduce drinking and is safe in adults with alcohol use disorder.

  Recruiting Phase 1 Newleos Therapeutics, Inc. · New Haven, Connecticut · NCT07520292

• Connecting hospitalized patients to alcohol care

  This pilot tests whether inviting in-hospital patients with alcohol use issues to meet an alcohol-use therapist for up to 10 sessions, versus giving guidance to seek care in the community, is feasible.

  Recruiting Zealand University Hospital · Køge · NCT07482150

• Social cognition in severe alcohol use disorder

  This study tests how social-cognition abilities relate to brain structure in adults with severe alcohol use disorder who are abstinent and receiving care.

  Recruiting CHU de Reims · Reims, Reims · NCT07464613

• Virtual-reality nature immersion for adults in outpatient alcohol treatment.

  This pilot will try immersive virtual-reality nature sessions to see if they help adults with alcohol use disorder and moderate-or-worse depression symptoms who are enrolled in an intensive outpatient program.

  Recruiting University of Michigan · Ann Arbor, Michigan · NCT07413458

• Peer support for liver transplant recipients with a history of alcohol use disorder

  This study tests whether having a peer support specialist helps liver transplant recipients with prior alcohol use disorder stay abstinent and stay engaged in care.

  Recruiting Johns Hopkins University · Baltimore, Maryland · NCT07397598

• Brief alcohol-focused program tailored for people taking buprenorphine

  This project will try a short, opioid-informed alcohol counseling program for adults on prescribed buprenorphine who drink alcohol to see if it reduces drinking and helps them stay in treatment.

  Recruiting University of Notre Dame · Notre Dame, Indiana · NCT07342504

• Deep brain stimulation to reduce drinking and craving in severe alcohol use disorder

  This trial will test whether deep brain stimulation can safely reduce drinking and cravings in adults with severe, treatment‑resistant alcohol use disorder.

  Recruiting at 2 sites University of Cambridge · Cambridge, Cambridgeshire and 1 other locations · NCT07341230

• Apremilast for reducing alcohol craving in adults with alcohol use disorder

  This study will try two daily doses of apremilast versus placebo to see if they reduce alcohol craving in adults with moderate to severe alcohol use disorder.

  Recruiting at 3 sites Phase 2 National Institute on Alcohol Abuse and Alcoholism (NIAAA) · Los Angeles, California and 2 other locations · NCT07325266

• Transcutaneous auricular neurostimulation (tAN) for reducing alcohol withdrawal in people with alcohol use disorder

  This trial will try a five-day ear‑stimulation device (tAN) versus a sham device to reduce alcohol withdrawal symptoms in adults with moderate-to-severe alcohol use disorder.

  Recruiting Spark Biomedical, Inc. · Houston, Texas · NCT07281261

• Cannabidiol for different patterns of alcohol use

  This test will see if taking daily cannabidiol (CBD) helps adults who drink alcohol regularly drink less and have fewer alcohol-related problems.

  Recruiting Phase 2 University of Colorado, Denver · Aurora, Colorado · NCT07279558

• Alcohol Use Disorder Before and After Bariatric Surgery and How Surgery Is Addressed During Addiction Follow-up

  This project will see how bariatric surgery and whether clinicians consider the surgery during addiction follow-up relate to alcohol use disorder outcomes in adults treated for AUD at two French centers.

  Recruiting University Hospital, Strasbourg, France · Strasbourg · NCT07273955

• Coordinated care for alcohol problems in Goa

  This trial tests whether Coordinated Care for Alcohol Problems (CCAP) added to enhanced usual care helps adults with drinking problems in Goa, India, compared with enhanced usual care alone.

  Recruiting Sangath · Goa · NCT07260149

• Impact of MOUD Policy Changes During the Pandemic on Opioid and Alcohol Use Disorders

  This study tests how federal and state policy changes during the COVID-19 pandemic affected access to and use of medications for opioid use disorder among Veterans with opioid or alcohol use disorders.

  Recruiting Boston University · Boston, Massachusetts · NCT07232641

• Brenipatide for moderate-to-severe alcohol use disorder

  This trial will test whether brenipatide is safe and helps adults with moderate-to-severe alcohol use disorder who want to stop or cut down drinking.

  Recruiting at 4 sites Phase 3 Eli Lilly and Company · Birmingham, Alabama and 116 other locations · NCT07219966

• Brenipatide treatment for people with alcohol use disorder

  This trial will see if brenipatide helps adults with alcohol use disorder reduce drinking and is safe compared with a placebo.

  Recruiting at 54 sites Phase 3 Eli Lilly and Company · Scottsdale, Arizona and 114 other locations · NCT07219953

• See if semaglutide helps reduce risky drinking in veterans with alcohol use disorder

  This trial tests whether weekly injections of semaglutide can help veterans with moderate to severe alcohol use disorder drink less compared to placebo over 24 weeks.

  Recruiting at 18 sites Phase 3 VA Office of Research and Development · Long Beach, California and 18 other locations · NCT07218354

• BrainsWay Deep Transcranial Magnetic Stimulation (Deep TMS) for adults with alcohol use disorder

  This study will test whether BrainsWay Deep TMS can reduce heavy drinking in adults with moderate to severe alcohol use disorder compared with a sham procedure.

  Recruiting at 9 sites Brainsway · Tuscaloosa, Alabama and 10 other locations · NCT07216872

• Blocking orexin receptors to reduce alcohol use and stress-related drinking

  This trial tests whether taking suvorexant at bedtime helps adults with moderate to severe alcohol use disorder drink less and have smaller stress reactions.

  Recruiting Phase 2 Ohio State University · Columbus, Ohio · NCT07214207

• Hepatic Lipid Metabolism in Alcohol Use Disorder

  This study tests how alcohol use disorder affects liver lipid metabolism by comparing liver biopsy transcriptomes during early and later withdrawal in adults undergoing inpatient detoxification.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT07191561

• TMS to help recovery in people with opioid and alcohol use disorders

  This study tests whether short daily TMS sessions can help people with opioid and alcohol use disorders improve recovery outcomes when added to their regular treatment.

  Recruiting Washington State University · Portland, Oregon · NCT07171359

• MDMA-assisted therapy for veterans with PTSD and alcohol use disorder

  This study tests MDMA-assisted therapy versus a low-dose MDMA placebo with psychotherapy to see if it helps veterans who have PTSD and problem drinking.

  Recruiting at 2 sites Phase 2/3 VA Office of Research and Development · West Haven, Connecticut and 1 other locations · NCT07118839

• Action-based cognitive remediation for alcohol and cannabis misuse in early psychosis

  This project will test whether action-based cognitive remediation helps young people with early psychosis cut down on alcohol and cannabis use.

  Recruiting at 2 sites Nova Scotia Health Authority · St. John's, Newfoundland and Labrador and 1 other locations · NCT07056894

• Tirzepatide for people with metabolic alcohol-associated liver disease and alcohol use disorder

  This trial will test whether the weight-loss drug tirzepatide can help adults with alcohol use disorder and metabolic alcohol-associated liver disease reduce drinking, lose weight, and lower liver fat.

  Recruiting Phase 2 National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT07046819

• Apremilast vs. placebo for adults with alcohol use disorder

  This study tests whether apremilast 60 mg daily helps adults with alcohol use disorder reduce drinking compared with a placebo.

  Recruiting Phase 2 Yale University · New Haven, Connecticut · NCT07029529

• Alcohol's immediate effects on brain PDE4B imaging

  This will see if a controlled intravenous dose of alcohol increases PET tracer binding to PDE4B in healthy adults who drink socially.

  Recruiting Phase 1 National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT07027839

• Tirzepatide to help reduce drinking in adults with alcohol use disorder who are overweight

  This trial will test whether weekly tirzepatide injections help adults with alcohol use disorder and overweight or obesity drink less and improve heart and metabolic health compared with placebo.

  Recruiting Phase 2 University of Southern California · Los Angeles, California · NCT06994338

• Psychotherapy for Alcohol Use Disorder focusing on Self-Concept and Memory

  This study is testing if therapy that focuses on how people see themselves and their memories can help individuals with Alcohol Use Disorder reduce their drinking and improve their self-image.

  Recruiting CHU de Reims · Reims · NCT06985927

• Using brain stimulation to reduce cravings and improve control in people with substance use disorders

  This study is testing if a type of brain stimulation can help people with alcohol use disorder feel less cravings and have better control during their detox treatment.

  Recruiting Central Institute of Mental Health, Mannheim · Mannheim and 1 other locations · NCT06959342

• Tirzepatide's effects on alcohol intake in patients with schizophrenia and alcohol use disorder

  This study is testing if the medication tirzepatide can help people with schizophrenia and alcohol use disorder drink less alcohol over six months.

  Recruiting at 2 sites Phase 2 Psychiatric Centre Rigshospitalet · Aalborg, Denmark and 1 other locations · NCT06939088

• Investigating how the septal nuclei in the brain relate to alcohol use disorder

  This study is trying to see how certain parts of the brain are connected to alcohol use disorder by comparing brain activity in people with the disorder to those without it while they look at alcohol-related images.

  Recruiting Psychiatric Centre Rigshospitalet · Frederiksberg · NCT06866379

• Link between alcohol use and surgical outcomes at University Hospitals

  This study is trying to see if higher alcohol use, measured by a specific marker in the blood, affects recovery and complications in patients who have elective surgery and stay in the hospital for a few days.

  Recruiting University Hospitals Cleveland Medical Center · Cleveland, Ohio · NCT06864819

• Effects of environment on drinking behaviors in people with alcohol use disorder

  This study is testing how different activities and surroundings can help people with alcohol use disorder drink less and feel better.

  Recruiting Phase 1 National Institutes of Health Clinical Center (CC) · Baltimore, Maryland · NCT06860607

• New blood test to help identify and track depression and early schizophrenia

  This project will try a new blood test to see if it can identify and track depression or early schizophrenia in adults receiving psychiatric care.

  Recruiting Fraser Health · New Westminster, British Columbia · NCT06856161

• See if PrEP for WINGS helps with starting and sticking to PrEP among women in community supervision programs

  This study tests PrEP for WINGS plus PrEP compared with PrEP alone to see if it increases PrEP initiation and adherence among cisgender women in CSPs who use alcohol hazardously and may face IPV and HIV risk.

  Recruiting Columbia University · New York, New York · NCT06853314

• Effects of a ketone supplement on brain power and drinking in alcohol use disorder

  In people with alcohol use disorder, this study tests whether a ketone supplement called Kenetik, vs a placebo, can change brain function and reduce alcohol consumption.

  Recruiting Phase 2/3 University of Pennsylvania · Philadelphia, Pennsylvania · NCT06807918

• Imaging brain protein levels in people with alcohol use disorder

  This study is testing if the levels of a brain protein called PDE4B change in people with alcohol use disorder during withdrawal and after they stop drinking for a while.

  Recruiting Phase 1 National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT06795581

• Anxiety during abstinence in people with alcohol use disorder

  This project will test whether anxiety and related brain activity change from early to three months of abstinence in people with alcohol use disorder who take disulfiram, compared with healthy volunteers.

  Recruiting Early Phase 1 Columbia University · New York, New York · NCT06793488

• Modified ketogenic diet to help reduce drinking in adults with alcohol use disorder

  This trial will test whether a modified ketogenic diet can help adults with alcohol use disorder reduce their alcohol consumption while they receive withdrawal care.

  Recruiting University of Bern · Bern · NCT06787235

• Reducing alcohol use and improving HIV treatment for men in fishing communities

  This study is testing a new program to help men with HIV in fishing communities cut down on drinking and stick to their HIV treatment to improve their health.

  Recruiting San Diego State University · Kampala · NCT06771843

• PT150 drug for treating alcohol use disorder

  This study is testing if the drug PT150 can help people with alcohol use disorder feel less stressed and reduce their alcohol cravings.

  Recruiting Phase 1 Pop Test Oncology LLC · Lexington, Kentucky · NCT06712602

• Impact of physical activity on sleep quality for people with alcohol use disorder

  This study is testing whether a supervised exercise program can help improve sleep quality for people struggling with alcohol use disorder.

  Recruiting Centre Hospitalier Universitaire de Besancon · Besançon · NCT06706349

• Digital harm reduction treatment for alcohol use disorder

  This study is testing a new online treatment for alcohol use disorder to see if it helps people who have been homeless and are now in supportive housing feel better and reduce alcohol-related problems compared to regular services.

  Recruiting Phase 3 University of Washington · Seattle, Washington · NCT06702007

• Exploring the effects of heavy alcohol use on oral health and saliva

  This study is trying to see how heavy drinking affects oral health and inflammation in people with alcohol use disorder compared to those without it.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT06684483

• Validation of the French version of the PAWSS scale for alcohol withdrawal prediction

  This study is testing a French version of a scale to see if it can accurately predict alcohol withdrawal symptoms in people with alcohol use disorders who are in the hospital.

  Recruiting Etablissement Public de Santé Barthélemy Durand · Étampes · NCT06675539

• New treatment using robot-guided magnetic stimulation for alcohol use disorder

  This study is testing a new robot-guided treatment to help people with alcohol use disorder cut back on their drinking by targeting specific areas of the brain.

  Recruiting The University of Texas Health Science Center at San Antonio · San Antonio, Texas · NCT06648642

• Guanfacine extended-release to reduce drinking in people with alcohol use disorder

  We will test whether taking guanfacine extended-release (3 mg daily) helps reduce drinking in adults with moderate to severe alcohol use disorder over 12 weeks.

  Recruiting at 2 sites Phase 2 Indiana University · Indianapolis, Indiana and 1 other locations · NCT06629259

• Ketamine paired with Acceptance and Commitment Therapy for people with alcohol problems and depression

  This will test whether combining ketamine infusions with Acceptance and Commitment Therapy helps adults who have both alcohol use disorder and treatment-resistant depression.

  Recruiting Centre hospitalier de l'Université de Montréal (CHUM) · Montreal, Quebec · NCT06620276

• Motivational interviews to help maintain abstinence after alcohol withdrawal

  This study tests if using motivational interviews as extra support can help adults who have just gone through alcohol withdrawal stay sober longer compared to regular care.

  Recruiting University Hospital, Montpellier · Montpellier · NCT06618755

• Effects of alcohol on stress and brain chemistry

  This study is testing how drinking alcohol affects stress and brain chemistry in people to find better ways to help reduce harmful drinking habits.

  Recruiting Yale University · New Haven, Connecticut and 1 other locations · NCT06584448

• Ketone supplement to reduce alcohol withdrawal symptoms and change brain metabolism

  This will test whether a 4-day oral ketone supplement can reduce alcohol withdrawal symptoms and alter brain metabolism in adults with moderate to severe alcohol use disorder during inpatient detox.

  Recruiting Phase 2/3 University of Pennsylvania · Philadelphia, Pennsylvania · NCT06559995

• Screening and evaluation for substance use disorders at NIDA

  This study is trying to see if people with and without substance use disorders can join future research at NIDA to help understand drug use and improve treatments.

  Recruiting National Institutes of Health Clinical Center (CC) · Baltimore, Maryland · NCT06552741

• Using ultrasound to treat alcohol use disorder

  This study is testing if using low-intensity ultrasound can help change brain activity in people with alcohol use disorder.

  Recruiting University of California, San Francisco · San Francisco, California · NCT06518785

• Understanding motivations for self-administering alcohol in people with alcohol use disorder

  This study is trying to understand why people with alcohol use disorder choose to drink alcohol by looking at their feelings, thoughts, and reactions while they self-administer alcohol in a controlled setting.

  Recruiting Phase 2 University of California, Los Angeles · Los Angeles, California · NCT06494891

• Referral to alcohol treatment for patients with liver disease

  This study tests whether sending newly diagnosed patients with alcohol-related liver disease to specialized treatment can help them stop drinking better than just regular care alone.

  Recruiting Zealand University Hospital · Køge, Køge · NCT06493773

• Developing a new method to screen medications for Alcohol Use Disorder

  This study is testing a new way to see how well people with Alcohol Use Disorder can resist drinking when faced with alcohol cues and rewards for not drinking.

  Recruiting Yale University · New Haven, Connecticut · NCT06489782

• Peer recovery coaching for hospitalized patients with alcohol use disorder

  This study is testing whether a peer recovery coaching program can help hospitalized patients with alcohol use disorder drink less and improve their overall well-being.

  Recruiting at 2 sites Clemson University · Greenville, South Carolina and 1 other locations · NCT06479681

• Exploring how sex differences affect treatment response in alcohol use disorder

  This study is trying to see if men and women respond differently to a medication for alcohol use disorder and how factors like trauma and emotions might play a role in that.

  Recruiting Phase 4 Oregon Health and Science University · Portland, Oregon · NCT06426303

• Functional connectivity–guided transcranial magnetic stimulation for alcohol use disorder

  This study will test whether a single fMRI-guided session of transcranial magnetic stimulation (TMS) can reduce alcohol-cue brain reactivity and help people with moderate-to-severe alcohol use disorder stay abstinent.

  Recruiting VA Palo Alto Health Care System · Palo Alto, California · NCT06415721

• Psilocybin versus ketamine for reducing heavy drinking in alcohol use disorder

  This trial will test whether a single 30 mg dose of psilocybin or a weight-based 0.75 mg/kg dose of ketamine, each given with individual psychotherapy, can reduce heavy drinking in adults with moderate to severe alcohol use disorder.

  Recruiting Phase 2 University of Iowa · Iowa City, Iowa · NCT06405607

• Non-invasive vagus nerve stimulation for treating alcohol use disorder in veterans

  This study is testing if a new treatment using non-invasive vagus nerve stimulation can help veterans with alcohol use disorder by reducing their cravings and withdrawal symptoms.

  Recruiting VA Office of Research and Development · San Diego, California · NCT06399653

• Integrated treatment to help adolescents recover from substance use disorders

  This study is testing a new combined therapy approach to help teenagers aged 14-21 recover from alcohol and cannabis use disorders and see if it works better than the standard treatment.

  Recruiting at 2 sites Massachusetts General Hospital · Farmington, Connecticut and 1 other locations · NCT06395467

• Peer support for people with alcohol dependence

  This study tests whether peer support from someone with lived experience of addiction helps adults with alcohol use disorder stay in care and improve outcomes after detox.

  Recruiting Hospices Civils de Lyon · Bron and 4 other locations · NCT06381609

• Imaging brain changes in PTSD and Alcohol Use Disorder

  This study is testing if brain imaging can help us understand how a specific marker is related to PTSD and Alcohol Use Disorder in people who have these conditions.

  Recruiting Yale University · New Haven, Connecticut · NCT06371404

• How psilocybin might change brain responses and behavior in people with alcohol use disorder

  This Phase 2 trial will test whether psilocybin given with supportive therapy helps adults with moderate to severe alcohol use disorder and changes brain responses related to craving and negative emotion.

  Recruiting Phase 2 NYU Langone Health · New York, New York · NCT06349083

• Investigating the effects of Suvorexant on alcohol use

  This study is testing if a medication called Suvorexant can help people with Alcohol Use Disorder feel less motivated to drink alcohol.

  Recruiting Early Phase 1 University of Kentucky · Lexington, Kentucky · NCT06326684

• Engagement of community health workers to support recovery from substance use disorders

  This study is testing whether support from community health workers can help people with substance use disorders engage better in treatment and improve their recovery experience after visiting the emergency department.

  Recruiting University of California, Los Angeles · Providence, Rhode Island · NCT06320015

• Disulfiram (Antabuse) for vision in retinal degeneration

  This study will test whether taking oral disulfiram (Antabuse) improves vision in adults with retinal degeneration who are also being treated for alcohol use disorder.

  Recruiting Phase 1 University of Rochester · Rochester, New York · NCT06319872

• Implementing patient-centered care for alcohol use issues

  This study tests two new ways to improve care for people dealing with alcohol use issues in primary care clinics to see if they can help patients make better decisions about their treatment.

  Recruiting Kaiser Permanente · Seattle, Washington · NCT06318026

• Mobile app for alcohol cessation in liver disease patients

  This study is testing whether a smartphone app can help people with alcohol-related liver disease stop drinking more effectively than just regular care alone.

  Recruiting at 3 sites University of Wisconsin, Madison · Lansing, Michigan and 2 other locations · NCT06305624

• Using virtual reality to help people in early recovery from alcohol use disorder

  This study is testing a new virtual reality program to see if it can help people in early recovery from alcohol use disorder drink less and stay sober.

  Recruiting Indiana University · Indianapolis, Indiana · NCT06302413

• Understanding how acamprosate affects brain function in alcohol use disorder

  This study is testing whether acamprosate can improve brain function and reduce anxiety and cravings in people with alcohol use disorder.

  Recruiting Phase 4 National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT06269627

• Telehealth program using blood tests to help treat alcohol use disorder

  This study is testing a new telehealth program that uses blood tests to help people with alcohol use disorder by combining online therapy with rewards for submitting their test results.

  Recruiting Washington State University · Spokane, Washington · NCT06265506

• Understanding relapse factors in alcohol use disorder

  This study is trying to find out what factors make people with alcohol use disorder more likely to relapse so that we can better understand and support their recovery.

  Recruiting Cliniques universitaires Saint-Luc- Université Catholique de Louvain · Brussels, Brussels Capital · NCT06244641

• One-year Parent-Child Assistance Program for parents with recent substance use

  This project will test whether a one-year Parent-Child Assistance Program helps parents who used substances during pregnancy stay with or reunify with their children and support their recovery.

  Recruiting at 2 sites University of Oklahoma · Enid, Oklahoma and 1 other locations · NCT06163651

• Exploring the effects of gut microbiota on inflammation in people with HIV and alcohol use disorder

  This study tests whether taking prebiotics can help reduce inflammation and improve gut health in people with HIV who also struggle with alcohol use disorder.

  Recruiting Rush University Medical Center · Chicago, Illinois · NCT06139224

• Understanding brain activity during alcohol intoxication and aggression

  This study tests how drinking alcohol affects brain activity related to social cues and aggression in people.

  Recruiting Phase 2 Ohio State University · Columbus, Ohio · NCT06118580

• Understanding stress responses in individuals with alcohol use disorder

  This study looks at how people with alcohol use disorder react to stress and whether these reactions affect their cravings and drinking habits over time.

  Recruiting at 2 sites Central Institute of Mental Health, Mannheim · Mannheim, Baden-Wurttemberg and 1 other locations · NCT06105853

• Ketamine for Depression in people with Alcohol Use Disorder

  This study tests whether adding ketamine to standard inpatient addiction therapy helps adults who have both depression and alcohol use disorder.

  Recruiting Phase 1/2 University Hospital of North Norway · Tromsø · NCT06090422

• Translating and validating a questionnaire for opioid misuse in Swedish pain patients

  This study is testing a new Swedish questionnaire to see if it can help identify opioid misuse among pain patients who are using opioids for treatment.

  Recruiting Uppsala University · Uppsala, Uppland · NCT06084520

• Reducing alcohol use in PrEP users through SBIRT intervention

  This study is testing if a program that helps people cut down on drinking can improve the health of those using PrEP for HIV prevention and help them stick to their medication.

  Recruiting University of Louisville · Louisville, Kentucky · NCT06005298

• Using repetitive TMS to improve thinking skills in people with alcohol use disorder

  This study is testing whether a special brain treatment can help improve thinking skills in people who have stopped drinking alcohol.

  Recruiting Universidad Nacional Autonoma de Mexico · Querétaro City, Querétaro · NCT05997212

• Using psilocybin with therapy to help reduce heavy drinking in people with alcohol use disorder

  This study is testing if a single dose of psilocybin, along with therapy, can help people with alcohol use disorder drink less over 12 weeks.

  Recruiting Phase 2 University of Calgary · Calgary, Alberta · NCT05995769

• Using intranasal insulin to treat alcohol use disorder

  This study is testing if using intranasal insulin can help people with alcohol use disorder by seeing how it affects them when they drink alcohol.

  Recruiting Phase 1/2 Brown University · Providence, Rhode Island · NCT05988632

• Combining Cognitive Processing Therapy and Relapse Prevention for PTSD and Alcohol Use Disorder

  This study is testing if a new combined treatment of therapy for PTSD and help for alcohol use can work better than just the alcohol help alone for people dealing with both issues.

  Recruiting at 2 sites Phase 2 Texas A&M University · Charleston, South Carolina and 1 other locations · NCT05959434

• Investigating the balance of opioid receptors in alcohol use disorder

  This study is testing how the levels of certain brain receptors are different in people with alcohol use disorder compared to healthy individuals to see how these differences affect cravings, mood, and withdrawal during early recovery.

  Recruiting Early Phase 1 Yale University · New Haven, Connecticut · NCT05957159

• Digital RITch®CBT versus standard one-on-one CBT for men with substance use and partner aggression

  This trial will test whether a self-guided digital program called RITch®CBT helps men in addiction treatment who have recently shown aggression toward intimate partners, compared with standard one-on-one CBT.

  Recruiting University of Rochester · Rochester, New York · NCT05943171

• Understanding impulsivity and alcohol response in young adults

  This study is trying to see how impulsivity affects young adults' reactions to alcohol to find new ways to prevent and treat alcohol misuse.

  Recruiting at 2 sites Early Phase 1 Ohio State University · Boston, Massachusetts and 1 other locations · NCT05929677

• CMND-100 for healthy volunteers and people with alcohol use disorder

  This trial will test single and repeated doses of an experimental medicine called CMND-100 in healthy volunteers and in people with moderate to severe alcohol use disorder to find safe doses and see if it reduces drinking and craving.

  Recruiting at 4 sites Phase 1/2 Clearmind Medicine Inc. · New Haven, Connecticut and 3 other locations · NCT05913752

• Assessing Patients with Alcohol and Cannabis Use Disorders

  This study is testing how a 12-week therapy program can help people with alcohol and cannabis use disorders by looking at how their thinking and feelings before treatment relate to their progress during therapy.

  Recruiting Centre for Addiction and Mental Health · Toronto, Ontario · NCT05855668

• Evaluating liver disease screening for individuals with alcohol use disorder

  This study tests if screening for liver disease with a special measurement helps people in alcohol treatment stay sober or drink less over six months.

  Recruiting at 2 sites Zealand University Hospital · Køge and 1 other locations · NCT05855031

• Understanding how alcohol affects young adults with bipolar disorder

  This study looks at how alcohol affects young adults with bipolar disorder compared to their peers to see if it leads to problems with drinking over time.

  Recruiting University of Texas at Austin · Austin, Texas · NCT05838274

• Emergency Department treatment for Alcohol Use Disorder

  This study tests a new approach in the Emergency Department that combines medication and support to help people with moderate to severe alcohol use disorder reduce their drinking and stay engaged in treatment.

  Recruiting Phase 3 Yale University · New Haven, Connecticut · NCT05827159

• Testing spironolactone for treating alcohol use disorder

  This study is testing if the medication spironolactone can help people with alcohol use disorder drink less by seeing how it works in their bodies.

  Recruiting Phase 1 National Institutes of Health Clinical Center (CC) · Baltimore, Maryland · NCT05807139

• Culturally informed intervention to reduce alcohol problems in Latinx individuals

  This study is testing a new culturally tailored program to help Latinx individuals who have had alcohol-related injuries reduce their drinking problems and get better support for treatment.

  Recruiting University of Texas, El Paso · El Paso, Texas · NCT05800899

• Exploring the link between alcohol misuse, PTSD, and intimate partner violence in couples

  This study is testing how alcohol misuse and PTSD affect violence between partners in couples to find better ways to prevent and treat these issues.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT05786157

• Using pregnenolone to treat Alcohol Use Disorder

  This study is testing if taking pregnenolone can help people with Alcohol Use Disorder drink less and feel better mentally over 12 weeks.

  Recruiting Phase 2 Yale University · New Haven, Connecticut · NCT05781009

• Testing a new intervention to help young adults stop drinking alcohol

  This study is testing a new online program to help young adults aged 18-24 stop drinking alcohol and see if it works better than just providing rewards for not drinking.

  Recruiting University of Illinois Chicago · Chicago, Illinois · NCT05778734

• Understanding the role of the cerebellum in alcohol use disorder

  This study is testing if a brain stimulation technique can help people with alcohol use disorder by looking at how a part of the brain called the cerebellum affects their cravings and responses to alcohol.

  Recruiting Johns Hopkins University · Baltimore, Maryland · NCT05732207

• Understanding how sleep affects alcohol use in young adults

  This study looks at how sleep and stress affect drinking habits in young adults aged 18-24 to see if better sleep can help reduce risky drinking.

  Recruiting University of Oregon · Eugene, Oregon · NCT05684094

• Understanding taste and smell differences in people with alcohol use disorder

  This study is trying to see how taste and smell are different in people with alcohol use disorder compared to those without, to understand how these differences might affect drinking habits.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT05677321

• Telehealth treatment for alcohol use disorder involving family support

  This study is testing a new telehealth program that includes family support to see if it helps Veterans with alcohol use disorder do better in treatment compared to standard care alone.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT05674409

• Community partnerships to address the opioid crisis

  This study is testing a new online program that helps people recovering from opioid use disorder fix small legal issues that might be holding them back.

  Recruiting at 2 sites University of Michigan · Ann Arbor, Michigan and 1 other locations · NCT05665179

• Combined real-time fMRI neurofeedback and TMS for alcohol use disorder

  This project tests whether adding real-time fMRI neurofeedback and/or transcranial magnetic stimulation (TMS) to usual treatment helps adults in treatment for alcohol use disorder reduce drinking and cravings.

  Recruiting Auburn University · Auburn, Alabama · NCT05621538

• Web-based intervention for military spouses to reduce alcohol use

  This study tests a new online program designed to help military spouses cut down on alcohol use and encourage their service member partners to seek help.

  Recruiting Stanford University · Palo Alto, California · NCT05619185

• Using CBD to help reduce alcohol consumption in people with alcohol use disorder

  This study is testing whether CBD can help people with alcohol use disorder drink less and feel better over 12 weeks.

  Recruiting Phase 2/3 University of Colorado, Denver · Aurora, Colorado · NCT05613608

• Using a mobile app to reduce risky alcohol use and HIV risk

  This study is testing a mobile app that sends real-time messages to help people reduce risky drinking and lower their chances of HIV by encouraging safer choices when they visit certain locations.

  Recruiting at 2 sites University of Kentucky · New Haven, Connecticut and 1 other locations · NCT05576350

• Predicting and understanding pain six months after radiotherapy for head and neck cancer

  This project will see if people treated with radiotherapy for head and neck cancer who still have pain at six months are more likely to keep smoking or drinking, be depressed, feel very tired, or have worse overall quality of life.

  Recruiting University Hospital, Caen · Caen · NCT05505188

• Examining how cannabis affects alcohol consumption

  This study is testing how different types of cannabis affect drinking habits in heavy drinkers who use cannabis regularly.

  Recruiting Phase 2 Brown University · Providence, Rhode Island · NCT05389930

• Novel treatment for alcohol use disorder in veterans

  This study is testing a new computer-based training to help veterans with alcohol use disorder drink less and improve their recovery while they also receive standard care.

  Recruiting VA Office of Research and Development · San Diego, California · NCT05372029

• Intervention to reduce alcohol use in young people with early phase psychosis

  This study is testing a new therapy to see if it can help young people with early phase psychosis and alcohol problems improve their mental health and get back to school or work better than standard treatment.

  Recruiting Nova Scotia Health Authority · Halifax, Nova Scotia · NCT05365347

• Testing LGG for Alcohol Use Disorder and Liver Injury

  This study is testing if a probiotic called LGG can help people with Alcohol Use Disorder and liver issues drink less and improve their liver health over six months.

  Recruiting Phase 2 University of Louisville · Louisville, Kentucky · NCT05178069

• Preventing relapse in people with HIV and alcohol use issues

  This study is testing a new counseling program to help people with HIV who have relapsed in their alcohol use to see if it works better than regular alcohol counseling.

  Recruiting Johns Hopkins University · Baltimore, Maryland · NCT05163301

• Computer-based therapy for anxiety and alcohol use disorders

  This study is testing a computer-based therapy for people with both anxiety and alcohol use disorders to see if it helps them feel better compared to standard treatment.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT05117255

• Combining brain stimulation and cognitive training for alcohol use disorder

  This study is testing if combining brain stimulation with thinking exercises can help people with alcohol use disorder stay sober longer.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT05062369

• Combining donepezil with cognitive training to help reduce heavy drinking in people with alcohol use disorder

  This study is testing if a combination of a medication called donepezil and cognitive training can help people with alcohol use disorder drink less.

  Recruiting Phase 2 VA Connecticut Healthcare System · West Haven, Connecticut · NCT05042102

• Naltrexone treatment for heavy drinkers with Alcohol Use Disorder

  This study is testing if a long-acting injection of naltrexone can help heavy drinkers cut back on their alcohol use.

  Recruiting Phase 4 University of Pennsylvania · Philadelphia, Pennsylvania · NCT05028062

• Using brain stimulation to reduce alcohol cravings

  This study is testing if a type of brain stimulation can help people with alcohol use disorder reduce their cravings and drinking behavior.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT04998916

• Exploring how sex differences and hormones affect alcohol use disorder risk

  This study is trying to see how differences between men and women, along with hormones, affect the risk of developing alcohol use disorder, especially in women.

  Recruiting Ohio State University · Columbus, Ohio · NCT04929288

• Using brain stimulation to enhance psychotherapy for people with alcohol use issues

  This study is testing if adding brain stimulation to therapy can help people who struggle with alcohol use drink less and improve their overall treatment.

  Recruiting Phase 2 The Mind Research Network · Albuquerque, New Mexico · NCT04770025

• Using a ketone ester to reduce alcohol consumption in people with alcohol use disorder

  This study is testing if a special drink made from ketones can help people with alcohol use disorder drink less by changing how their brains react to alcohol.

  Recruiting Phase 2/3 University of Pennsylvania · Philadelphia, Pennsylvania · NCT04616781

• Testing glutamate modulators for reducing heavy drinking in individuals with alcohol use disorder

  This study tests if a new medication that affects brain chemicals can help people with alcohol use disorder drink less, especially when combined with therapy.

  Recruiting Phase 2 New York State Psychiatric Institute · New York, New York · NCT04084860

• Using brexpiprazole to treat alcohol use disorder

  This study is testing if a medication called brexpiprazole can help people with Alcohol Use Disorder drink less by looking at how it affects their brain while they respond to alcohol-related cues.

  Recruiting Phase 2 University of Colorado, Denver · Aurora, Colorado · NCT04066192

• Comparing early and standard liver transplant outcomes for alcohol use disorder treatment

  This study tests whether a new combined treatment for alcohol use, offered both in-person and online, can help people who are getting a liver transplant due to alcohol-related liver disease do better after their surgery compared to standard care.

  Recruiting Johns Hopkins University · Baltimore, Maryland · NCT03845205

• Examining how men and women respond differently to abstaining from alcohol.

  This study looks at how men and women react differently to stopping alcohol for a while to help understand their drinking habits better.

  Recruiting Phase 1 Indiana University · Indianapolis, Indiana · NCT03827460

• Using topiramate to treat alcohol use disorder and PTSD together

  This study is testing if the medication topiramate can help people who have both alcohol use disorder and PTSD feel better.

  Recruiting Phase 2 NYU Langone Health · New York, New York · NCT03667846

• Observing the natural history of alcohol use and its effects

  This study is trying to learn how different levels of alcohol use affect people's health by collecting information from a variety of drinkers, including those who want help and those who don't.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT02231840

• Community-based liver health assessment using noninvasive biomarkers

  This study is trying to see how well non-invasive tests can help identify liver health issues in people at risk, like those with diabetes or obesity, by gathering information from around 2,000 participants over four years.

  Recruiting University of Nottingham · Nottingham, Notts · NCT02037867

NIH-funded research (newest 40 of 259)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Functional Connectivity-Guided TMS for Alcohol Use Disorder

  A new approach uses targeted brain stimulation to help people with alcohol use disorder stay abstinent longer by focusing treatment on specific brain circuits.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11601597

• Alcohol Use Disorder and Suicidal Behavior: Finding Why They Occur Together

  A study using Swedish population data to understand why alcohol use disorder relates to suicidal thoughts and acts, with the goal of improving risk prediction and prevention.

  NIH research Virginia Commonwealth University · Richmond, United States · NIH-11601596

• Non-hallucinogenic psilocybin derivative for alcohol use disorder

  A new, safer psilocybin-like compound is being studied to help people with alcohol use disorder.

  NIH research Terp Life, LLC · Tampa, United States · NIH-11594445

• Identifying brain proteins linked to PTSD and alcohol use disorder

  Researchers are studying brain proteins that may contribute to PTSD and alcohol use disorder in US veterans to find new ways to help people who struggle with both conditions.

  NIH research VA Northern California Health Care Sys · Mather, United States · NIH-11578051

• Mu and Kappa Opioid Balance in Alcohol Use Disorder

  A study using brain imaging to understand how the brain’s opioid system changes during early sobriety in adults with alcohol use disorder.

  NIH research Yale University · New Haven, United States · NIH-11564204

• Telehealth support to prevent suicide in people with alcohol use disorder in Tanzania

  A telehealth counseling program is being adapted to help reduce suicide risk for people with alcohol use disorder in emergency departments in Tanzania.

  NIH research Duke University · Durham, United States · NIH-11519492

• Neural targets for improving function in Veterans with alcohol use disorder and mild brain injury

  This project tests a targeted brain-stimulation approach to help Veterans who have both alcohol use problems and mild traumatic brain injury improve daily functioning.

  NIH research Edward Hines Jr VA Hospital · Hines, United States · NIH-11518051

• Microglia as targets to reduce negative mood in alcohol use disorder

  This grant explores how brain immune cells called microglia contribute to negative feelings in people with alcohol use disorder and tests ways to calm them to improve mood.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11465406

• Augmented Reality app to help Veterans with Alcohol Use Disorder

  A smartphone AR app is being developed to support veterans with alcohol use disorder through cue-based, technology-enabled therapy.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11451985

• Psilocybin and brain stimulation to treat alcohol use disorder

  A Johns Hopkins research team is testing whether a combination of psilocybin and customized brain stimulation can reduce cravings and drinking in adults with alcohol use disorder.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11446309

• Understanding how alcohol affects pain in people with alcohol use disorder and chronic pain

  This study tests how alcohol changes pain sensitivity in adults with alcohol use disorder and chronic pain using a controlled IV alcohol setup.

  NIH research Yale University · New Haven, United States · NIH-11444910

• LIFT Clinic: Post-Transplant Alcohol Care Pilot

  A patient-centered plan to help people who had a liver transplant stay abstinent from alcohol, using structured monitoring and coordinated care.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11442475

• Alcohol Use Disorder Care in Primary Care: Making Treatment Easier and More Effective

  A primary care-based program helps people with alcohol use disorder get evidence-based medications and support over 12 weeks to improve drinking outcomes.

  NIH research Veterans Health Research Institute of Central New York, INC. · Syracuse, United States · NIH-11438214

• ORPBiT: A centralized omics repository for post-mortem brain tissue in alcohol use disorder

  A centralized data hub will organize and harmonize multi-omics data from post-mortem brains of people with alcohol use disorder to accelerate brain-disease insights.

  NIH research Indiana University Indianapolis · Indianapolis, United States · NIH-11422754

• Using Virtual Reality to Help Adults with Alcohol Use Disorder Cope in Real-Life Triggers

  A VR-based program helps adults with alcohol use disorder learn and practice coping skills in realistic high-risk situations to support abstinence.

  NIH research Brown University · Providence, United States · NIH-11420341

• Orexin Receptor Blockade to Help Treat Alcohol Use Disorder and Stress-Related Drinking

  A study tests a drug that blocks orexin receptors to help people with alcohol use disorder, especially those whose drinking worsens with stress.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11418534

• Probenecid for Alcohol Use Disorder

  A 12-week study at Brown University will test whether adding probenecid helps people with alcohol use disorder reduce drinking and cravings.

  NIH research Brown University · Providence, United States · NIH-11418416

• Digital Contingency Management for Opioid and Alcohol Use Disorder care

  A pilot test of a smartphone-based contingency management program to help people with both opioid use disorder and alcohol use disorder stay in treatment and reduce drinking.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11417268

• dTMS treatment targeting brain networks to help adults with alcohol use disorder

  This NIH grant tests whether deep transcranial magnetic stimulation can boost brain activity in key areas and reduce drinking in adults with alcohol use disorder.

  NIH research Palo Alto Veterans Instit for Research · Palo Alto, United States · NIH-11417162

• Understanding how stress and sex differences affect alcohol use in mice

  Aims to understand how stress and sex differences influence alcohol use by testing a drug that affects a brain signaling pathway in mice.

  NIH research Yale University · New Haven, United States · NIH-11416779

• Imaging sex differences in stress-related brain signals in alcohol use disorder

  A study at Yale will explore how stress and immune signals differ between women and men with alcohol use disorder and how these differences could guide better treatments.

  NIH research Yale University · New Haven, United States · NIH-11416772

• Phase 2a dose-response study of a medication for alcohol use disorder in women and men

  A phase 2a study at Yale will test how a medication called apremilast works at different doses for adults with alcohol use disorder, with attention to differences between women and men.

  NIH research Yale University · New Haven, United States · NIH-11416768

• Yale SCORE: sex differences in alcohol use disorder and new therapies for women

  A large Yale-led effort will study why women develop and maintain alcohol use disorder and test new treatment ideas especially for women.

  NIH research Yale University · New Haven, United States · NIH-11416755

• Gut microbes that produce ethanol and how they affect alcohol use and liver disease

  This grant studies whether bacteria in the gut that make ethanol can influence alcohol use and liver disease in people, including those with Autobrewery Syndrome and alcohol use disorder.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11416638

• Alcohol Use Disorder and Suicidal Behavior: Understanding the Links

  This grant examines how alcohol use disorder may influence suicidal thoughts and actions, using large national data to uncover risk factors and pathways that could improve prevention.

  NIH research Virginia Commonwealth University · Richmond, United States · NIH-11416403

• RXFP3-Targeted Drugs to Help with Alcohol Use Disorder

  A new drug approach aims to block a brain receptor (RXFP3) to reduce alcohol craving and drinking in people with alcohol use disorder.

  NIH research Research Triangle Institute · Research Triangle Park, United States · NIH-11415789

• Attentional Ability and Brain Resilience in Teens at Risk for Alcohol Use Disorder

  This project studies how attention and brain resilience help teenagers at risk for alcohol problems cope better and stay on a healthier path.

  NIH research University of Florida · Gainesville, United States · NIH-11415217

• Which alcohol use disorder treatment will work best for you

  This project uses data from past clinical trials and machine learning to predict how well different treatments for alcohol use disorder might work for individual patients.

  NIH research University of New Mexico · Albuquerque, United States · NIH-11414952

• Alcohol use screening and treatment in routine perioperative care

  A doctor-led program would screen hospitalized patients for unhealthy drinking and offer supportive care during and after surgery to improve recovery and health.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11413680

• GLP-1 receptor agonists for alcohol use disorder in real-world care

  This project looks at how GLP-1 receptor agonists used for diabetes and heart health perform in real-world adults with alcohol use disorder.

  NIH research Emory University · Atlanta, United States · NIH-11413626

• Intranasal insulin as a potential medicine for alcohol use disorder

  Testing a nasal insulin spray to see if it can safely help people with alcohol use disorder feel better and manage cravings.

  NIH research Brown University · Providence, United States · NIH-11411114

• Emergency department-initiated medicines for alcohol use disorder

  A study in ED patients with moderate to severe alcohol use disorder tests whether adding ED-initiated medications to SBIRT improves engagement in ongoing treatment after the ED visit.

  NIH research Yale University · New Haven, United States · NIH-11408751

• Understanding what drives alcohol use disorder and building a patient-friendly test

  A researcher at a major university is studying the underlying mechanisms of alcohol use disorder to create a practical test that could guide personalized treatments.

  NIH research University of New Mexico · Albuquerque, United States · NIH-11408718

• A Peer Recovery Coaching Program for Hospitalized Patients with Alcohol Use Disorder

  A hospital-based program connects patients with alcohol use disorder to peer recovery coaches to support ongoing care after discharge.

  NIH research Clemson University · Clemson, United States · NIH-11408610

• Once-daily extended-release acamprosate to help maintain abstinence in AUD

  A small, early-stage project is testing a new once-daily extended-release form of acamprosate to help people with alcohol use disorder stay abstinent more easily.

  NIH research Witii Pharmaceuticals, INC. · Denver, United States · NIH-11406496

• Neurosteroids, GABA, and Alcohol Use Disorder Treatment

  This research explores how brain chemicals called neurosteroids and the drug acamprosate might work together to help people with alcohol use disorder.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11406051

• Understanding mu and kappa opioid receptors in alcohol use disorder

  A study using PET scans and computer analysis to see how mu and kappa opioid receptors relate to cravings and relapse risk for adults trying to quit drinking.

  NIH research Yale University · New Haven, United States · NIH-11404926

• Multi-omic insights into alcohol use disorder with and without smoking

  A scientist team will study how DNA methylation and RNA patterns in brain tissue differ in people with alcohol use disorder, comparing those who smoke to those who don’t, to understand biology and potential drug targets.

  NIH research Research Triangle Institute · Research Triangle Park, United States · NIH-11402206

• Fine mapping of Alcohol Use Disorder to find genes linked to risk

  A large genetic study from Virginia Commonwealth University aims to map specific genes that contribute to alcohol use disorder by combining data from related psychiatric traits.

  NIH research Virginia Commonwealth University · Richmond, United States · NIH-11401908

• Neural effects of psilocybin for alcohol use disorder

  Aims to understand how psilocybin changes brain activity to help people with alcohol use disorder reduce drinking.

  NIH research New York University School of Medicine · New York, United States · NIH-11401907

Related topics

Quick answers

How many Alcohol Use Disorder clinical trials are recruiting right now?

138, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 19 countries. The most sites are in United States (103 trials), France (10 trials), Canada (6 trials), Denmark (5 trials), Belgium (4 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 23, Phase 1: 8, Phase 3: 6, Early Phase 1: 5. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

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