Improving sleep patterns in people with bipolar disorder
Official title: Correcting Circadian Rhythms in Bipolar Disorder: Uncovering Mechanisms
Funded at University of Michigan at Ann Arbor · NIH-10996157 · Data updated 2026-11-12
This study is looking at how fixing sleep patterns with a mix of low-dose afternoon melatonin and a regular sleep schedule can help adults with bipolar disorder feel better and sleep more soundly.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | December 7, 2023 |
| Project end | November 30, 2025 |
| Funding year | 2025 |
| Award (this year) | $165,750 |
| NIH project number | 5R21MH132901-02 |
| Project ID | NIH-10996157 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults diagnosed with bipolar disorder who experience circadian rhythm disruptions and related sleep issues.
✕Less likely to help
Patients with bipolar disorder who do not experience circadian rhythm disruptions or have other complicating health issues may not benefit from this research.
What this research studies
This research investigates how correcting disruptions in circadian rhythms can improve outcomes for adults with bipolar disorder. It focuses on a specific intervention that combines low-dose afternoon melatonin with a structured sleep schedule to address common sleep issues associated with bipolar disorder. By targeting the underlying circadian dysfunction, the study aims to enhance sleep quality and stabilize mood, potentially leading to better overall functioning for participants. The approach builds on existing therapies that indirectly address these issues, offering a more direct method of intervention.
Why it matters
Potential benefit: If successful, this research could lead to improved sleep and mood stabilization for individuals with bipolar disorder.
How similar studies have gone: Previous research has shown that interventions targeting circadian rhythms can be effective in improving sleep disorders, suggesting a promising avenue for this approach.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Swanson, Leslie M — University of Michigan at Ann Arbor
- Study coordinator: Swanson, Leslie M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.