Using neurofilament light chains to differentiate cognitive impairments in psychiatric and neurodegenerative diseases

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to validate neurofilament light chains as a biomarker for distinguishing cognitive and behavioral disorders of psychiatric origin from those of neurodegenerative origin. It will include 120 participants, divided into groups based on their diagnoses of schizophrenia, bipolar disorder, Alzheimer's disease, or frontotemporal dementia. Participants will undergo cognitive, behavioral, and psychiatric evaluations, along with blood sample collection for biomarker analysis. The study also includes a retrospective analysis of correlations between biomarkers in cerebrospinal fluid and plasma samples.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* haven given written consent

Participants with psychiatric conditions:

* Schizophrenia (DSM-V criteria) with or without cognitive involution
* Bipolar disorder (DSM-V criteria) with or without cognitive involution

Participants with neurodegenerative disease:

* probable or definite FTD (Rascovsky criteria 2011)
* Biological Alzheimer's disease with typical CSF (NIA-AA 2011)

Exclusion Criteria:

* Uninterviewable patient and/or missing history
* History of recent or previous head trauma with loss of consciousness
* History of ischemic or hemorrhagic stroke
* Chronic alcoholism / chronic drug use
* Progressive somatic pathology / severe metabolic disorder / poorly controlled epilepsy
* Age \< 45 years
* Age \> 80 years
* Electroconvulsive therapy for less than 6 months

Where it's running

• HCL Consultation mémoire Neurologique -Hôpital Neurologique
  Bron, France Recruiting
• Centre Hospitalier Le Vinatier
  Bron, France Recruiting

Study contacts

• Principal investigator: Jean-Michel DOREY, MD, PHD — CH le Vinatier
• Study coordinator: Dorey Jean-Michel, MD,PHD
• Email: jean-michel.dorey@ch-le-vinatier.fr
• Phone: 0437915249

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.