Investigating the effects of a key gene on bipolar disorder and stress responses
Official title: Characterizing the transcriptional and neuro-immune consequences of loss of high-confidence bipolar disorder risk gene KDM5B
Funded at Broad Institute, INC. · NIH-11119400 · Data updated 2026-11-12
This study is looking at how a missing gene related to bipolar disorder affects brain function and stress responses in mice, which could help us understand more about what happens in the brains of people with bipolar disorder.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Broad Institute, INC. NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project start | June 16, 2025 |
| Project end | June 15, 2027 |
| Funding year | 2025 |
| Award (this year) | $475,388 |
| NIH project number | 1R21MH140240-01 |
| Project ID | NIH-11119400 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with a family history of bipolar disorder or those who have experienced significant stress and mood disorders.
✕Less likely to help
Patients who do not have a diagnosis of bipolar disorder or related mood disorders may not benefit from this research.
What this research studies
This research explores how the loss of the KDM5B gene, which is linked to bipolar disorder, affects brain function and immune responses in mice. By examining the behavior and gene expression of mice with a partial loss of this gene under stress, the study aims to understand the biological mechanisms that may contribute to bipolar disorder. The researchers will analyze how stress influences these mice's behavior and the resulting changes in their brain's immune activity, which could lead to better insights into the disorder's development.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing bipolar disorder by targeting the underlying genetic and immune factors.
How similar studies have gone: Previous research has shown promising results in understanding the genetic and immune factors involved in bipolar disorder, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Broad Institute, INC.
Cambridge, United States Active
Researchers
- Principal investigator: Granger, Adam — Broad Institute, INC.
- Study coordinator: Granger, Adam
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.