Using rTMS to treat mood and cognitive symptoms of depression

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effects of repetitive transcranial magnetic stimulation (rTMS) on mood, cognitive impairment, anhedonia, and sleep disorders in patients with unipolar depression and bipolar disorder. It aims to compare the therapeutic potential of multi-site stimulation over the left dorsolateral prefrontal cortex (DLPFC) and dorsomedial prefrontal cortex (dmPFC) against stimulation over the DLPFC alone and a sham treatment. The study includes patients with moderate to severe depressive episodes and assesses their symptoms using standardized scales. By exploring this novel approach, the study seeks to optimize rTMS as a treatment option for those who are resistant to conventional pharmacotherapy.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* severe or moderate depressive episode (according to international classification of diseases (ICD)-10) without psychotic symptoms at the time of inclusion
* Hamilton Depression Rating Scale between between 20 and 35 points at inclusion
* The score in the Athens Insomnia Scale eight or more
* The score of three or more points in items 4 and 21 of the Beck Depressions Inventory 2
* Complaining about problems with memory and concentration timely related with the onset of depression

Exclusion Criteria:

* Contraindications to transcranial magnetic stimulation, including ferromagnetic elements in head, pregnancy and epilepsy
* Psychotic symptoms at the time of inclusion
* Suicidal ideations and/or attempts within three months prior to inclusion

Where it's running

• The Education of Research and Development Center, Babinski Clinical Hospital
  Krakow, Poland Recruiting

Study contacts

• Principal investigator: Wojciech Korzeniowski, MD — The Education of Research and Development Center, Babinski Clinical Hospital
• Study coordinator: Wojciech Korzeniowski, MD
• Email: wojciech.korzen@gmail.com
• Phone: +48 12 652 45 20

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.