Mapping brain structure differences in bipolar disorder and major depression

Large-scale fine mapping of brain morphometry in bipolar disorder and major depression

['FUNDING_R21'] · UNIVERSITY OF SOUTHERN CALIFORNIA · NIH-11037814

This study looks at how the brains of people with bipolar disorder and major depression are different from those of healthy individuals, using advanced imaging techniques to find specific brain patterns, which could help improve how we diagnose and treat these conditions.

Quick facts

Phase['FUNDING_R21']
Study typeNih_funding
SexAll
SponsorUNIVERSITY OF SOUTHERN CALIFORNIA (nih funded)
Locations1 site (Los Angeles, UNITED STATES)
Trial IDNIH-11037814 on ClinicalTrials.gov

What this research studies

This research investigates the brain structure variations in individuals with bipolar disorder and major depression by analyzing neuroimaging data collected globally. It utilizes advanced voxel-wise brain mapping techniques to identify specific brain signatures associated with these conditions. By comparing brain morphometry in a large sample of patients and healthy controls, the study aims to enhance understanding of the biological underpinnings of these mental health disorders. This approach could lead to improved diagnostic and treatment strategies based on biological measures.

Who could benefit from this research

Good fit: Ideal candidates for participation include individuals diagnosed with bipolar disorder or major depression, as well as healthy controls for comparison.

Not a fit: Patients with other mental health conditions not related to bipolar disorder or major depression may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to more accurate diagnoses and personalized treatment options for patients with bipolar disorder and major depression.

How similar studies have performed: Previous research using similar voxel-wise mapping techniques has shown promise in identifying brain structure differences in various psychiatric conditions, suggesting potential for success in this study.

Where this research is happening

Los Angeles, UNITED STATES

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.

View on NIH RePORTER →

Last reviewed 2026-05-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.