Physical exercise to improve cognitive function in bipolar disorder patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial evaluates the effects of structured physical exercise as an additional treatment for cognitive impairments in patients diagnosed with Bipolar Disorder. It involves 72 euthymic patients who will be randomly assigned to either a group receiving supervised exercise sessions three times a week for 12 weeks or a control group receiving standard treatment only. The study aims to assess changes in cognitive functions, quality of life, and functionality, as well as correlations with physiological variables. Assessments will be conducted at baseline and after the intervention period to determine the effectiveness of the exercise program.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Diagnosis of Bipolar disorder (BD) I and II according to DSM-5
* Age: 18 - 55 years old
* Complete primary education
* Euthymic (YMRS \< 8 and MADRS \< 12)
* Presence of cognitive impairments (COBRA \> 14 and SCIP \< 75)
* Estimated IQ ≥ 80
* No medication changes in the last month
* Having been without regular PE practice for six months
* Signature of the TCLE

Exclusion Criteria:

* Organic mental disorder
* BMI \> 40
* Alcohol or drug abuse in the last 6 months
* Use of benzodiazepines or beta-blockers in the last month

Where it's running

• Gabriel Okawa Belizario
  São Paulo, São Paulo, Brazil Recruiting

Study contacts

• Principal investigator: Beny Lafer, M.D, Ph.D — University of Sao Paulo
• Study coordinator: Gabriel Okawa Belizario
• Email: gabrielokawabelizario@gmail.com
• Phone: +55 (11) 963391570

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.