Condition

Schizoaffective Disorder clinical trials and research

• 32Clinical trials
• 1New in 30 days
• 7Countries

Newest Schizoaffective Disorder clinical trials

All recruiting trials (32)

• Theta-Burst Transcranial Magnetic Stimulation for Treatment-Resistant Auditory Hallucinations

  This study tests whether theta-burst transcranial magnetic stimulation can lessen persistent auditory verbal hallucinations in adults with schizophrenia-spectrum or psychotic disorders who have not responded to antipsychotic meds.

  Recruiting Ciusss de L'Est de l'Île de Montréal · Montreal, Quebec · NCT07902518

• Can seven tasks help distinguish schizophrenia and schizoaffective disorder from healthy people

  The study tests seven cognitive tasks to see if they can tell apart people with schizophrenia or schizoaffective disorder from healthy adults and predict symptoms like hallucinations and delusions.

  Recruiting at 5 sites Washington University School of Medicine · Irvine, California and 4 other locations · NCT07853807

• State Representation in Early Psychosis 2

  This observational study tests how people with early psychosis and healthy individuals use state information during tasks and how brain activity supports it.

  Recruiting at 2 sites University of Minnesota · Minneapolis, Minnesota and 1 other locations · NCT07834203

• Brain-derived miRNA biomarkers in first-episode psychosis

  Researchers will test whether specific brain-derived microRNAs in blood can help identify schizophrenia early and track treatment in people with first-episode psychosis on aripiprazole or risperidone.

  Recruiting Northwell Health · Glen Oaks, New York · NCT07703670

• Trying the Kiso Mind smartphone app for people with schizophrenia spectrum disorders

  This study tests whether the Kiso Mind smartphone app is acceptable, practical, and helpful for adults with schizophrenia or schizoaffective disorder alongside their usual care.

  Recruiting Charite University, Berlin, Germany · Berlin, State of Berlin · NCT07395206

• Cognitive Strategies in Early Psychosis 2 – how brain games and pills test decision making

  This study tests whether a single dose of modafinil or d-serine, compared with placebo, changes decision making in people aged 18–35 who have recently begun experiencing psychosis.

  Recruiting Phase 3 University of Minnesota · Minneapolis, Minnesota · NCT07263022

• Valbenazine for adults with tardive dyskinesia who remain symptomatic on or after a VMAT2 inhibitor

  This trial will test whether valbenazine reduces involuntary movements in adults with tardive dyskinesia who still have symptoms while taking or after stopping a VMAT2 inhibitor.

  Recruiting at 19 sites Phase 4 Neurocrine Biosciences · Bryant, Arkansas and 18 other locations · NCT07105111

• iTEST: a blended mobile program to improve introspective accuracy (accurate self-judgment of abilities)

  This trial tests whether iTEST — daily mobile cognitive training plus coaching that focuses on accurate self-judgment — helps adults with schizophrenia-spectrum or other psychotic disorders improve community functioning.

  Recruiting at 3 sites University of California, San Diego · San Diego, California and 2 other locations · NCT07098169

• Outdoor versus indoor exercise to reduce negative symptoms in schizoaffective disorder

  This project will test whether 8 weeks of outdoor exercise helps adults (18–55) with schizoaffective disorder and persistent negative symptoms more than the same exercise done indoors.

  Recruiting Centre Hospitalier Universitaire de Saint Etienne · Saint-Etienne, France · NCT07058389

• Using 40 Hz visual stimulation to help with negative symptoms in schizophrenia

  This study is testing if 40 Hz visual stimulation can help people with schizophrenia or schizoaffective disorder feel better by reducing negative symptoms.

  Recruiting Technical University of Munich · Munich, Bavaria · NCT06907420

• Using AI to Improve Rehabilitation for Patients with Severe Mental Disorders

  This study is testing if using AI and fun games can help people with severe mental disorders improve their social skills and get back into the community.

  Recruiting Shanghai Mental Health Center · Shanghai · NCT06904079

• Enhancing Veteran-Clinician Collaboration in VA Care for Serious Mental Illness

  This study tests a 10-session group program to help Veterans with serious mental illness collaborate better with their clinicians and care teams.

  Recruiting VA Office of Research and Development · San Diego, California and 2 other locations · NCT06898879

• Context-aware mobile program to boost social recovery in serious mental illness

  This project will test a blended mobile and in-person therapy called mSITE to help adults with schizophrenia or schizoaffective disorder increase how often they interact with other people.

  Recruiting University of California, San Diego · San Diego, California · NCT06865937

• Understanding decision-making in schizophrenia through brain imaging and daily experiences

  This study is testing how attention and thinking strategies affect decision-making in people with schizophrenia while they do tasks in an MRI scanner, to see if it helps them make better choices in everyday life.

  Recruiting Rutgers, The State University of New Jersey · Piscataway, New Jersey · NCT06745479

• Aerobic exercise added to olanzapine‑samidorphan treatment

  This trial will try whether adding four weeks of supervised aerobic exercise to olanzapine‑samidorphan reduces antipsychotic-related weight gain in adults with schizophrenia or bipolar disorders.

  Recruiting Phase 4 New York State Psychiatric Institute · New York, New York · NCT06740890

• Understanding early psychosis and its biological markers

  This study is trying to find out more about early signs of psychotic disorders like schizophrenia and bipolar disorder by looking at brain scans and other health data from around 320 participants over a year.

  Recruiting at 6 sites Beth Israel Deaconess Medical Center · Hartford, Connecticut and 5 other locations · NCT06740383

• Magnetic seizure therapy versus electroconvulsive therapy for treatment‑resistant schizophrenia

  This trial will test whether magnetic seizure therapy works as well as a specific form of electroconvulsive therapy for adults whose schizophrenia or schizoaffective disorder has not improved with medications.

  Recruiting at 2 sites Centre for Addiction and Mental Health · Vancouver, British Columbia and 1 other locations · NCT06672588

• Improving rehabilitation for veterans with serious mental illness

  This study is testing a new computer program to help veterans with serious mental illnesses improve their thinking and daily life skills.

  Recruiting VA Office of Research and Development · San Diego, California · NCT06586164

• Reducing unnecessary anticholinergic medications in schizophrenia

  This study tests if stopping unnecessary anticholinergic medications can help people with schizophrenia feel better and improve their daily functioning.

  Recruiting Phase 4 University of Pittsburgh · Pittsburgh, Pennsylvania · NCT06562608

• Community-based cognitive remediation program for schizophrenia and schizoaffective disorder

  This study tests a community program that helps adults with schizophrenia and schizoaffective disorder improve their thinking skills through exercises and group support to see if it makes their daily lives better.

  Recruiting at 3 sites Singapore Institute of Technology · Singapore and 4 other locations · NCT06286202

• Ketogenic diet and nutritional interventions for first episode bipolar disorder

  This study is testing if a ketogenic diet, along with regular treatment, can help people who are having their first episode of bipolar disorder or schizoaffective disorder feel better and improve their brain health.

  Recruiting Mclean Hospital · Belmont, Massachusetts · NCT06221852

• Using magnetic stimulation to improve cognition in psychotic disorders

  This study is testing whether a type of brain stimulation called TMS can help improve thinking skills in people with psychotic disorders like schizophrenia and bipolar disorder.

  Recruiting at 2 sites Mclean Hospital · Belmont, Massachusetts and 1 other locations · NCT06107764

• Enhanced care for early psychosis treatment

  This study is testing whether a new, more supportive treatment for people experiencing their first episode of psychosis helps them stay engaged in their care better than standard treatment.

  Recruiting at 5 sites Mclean Hospital · Belmont, Massachusetts and 4 other locations · NCT06071858

• Training to improve metacognitive skills in patients with psychotic disorders

  This study is testing whether a group program that teaches metacognitive skills can help people with psychotic disorders improve their thinking and social skills.

  Recruiting University of Jyvaskyla · Vaasa · NCT06005766

• Improving cognition through telehealth exercise and cognitive training for first-episode schizophrenia

  This study is testing whether combining online exercise and brain training can help people who are experiencing their first episode of schizophrenia improve their thinking skills.

  Recruiting University of California, Los Angeles · Los Angeles, California · NCT05890183

• Using clozapine to reduce violence in people with schizophrenia

  This study is testing if the medication clozapine can help reduce violent behavior in adults with schizophrenia or schizoaffective disorder.

  Recruiting at 7 sites Phase 4 New York State Psychiatric Institute · Los Angeles, California and 6 other locations · NCT05208190

• Evaluating clozapine's effectiveness in specific psychosis patients

  This study is testing if clozapine works better than risperidone for people with schizophrenia, schizoaffective disorder, and bipolar I disorder who have a specific brain activity pattern.

  Recruiting at 5 sites Phase 4 University of Texas Southwestern Medical Center · Hartford, Connecticut and 4 other locations · NCT04580134

• Synbiotic supplement to reduce schizophrenia symptoms

  It will test whether taking a synbiotic supplement with regular antipsychotic medication helps adults with schizophrenia or schizoaffective disorder who still have moderate psychotic symptoms.

  Recruiting Phase 2 Sheppard Pratt Health System · Batlimore, Maryland · NCT04226898

• Smoking cessation treatment for schizophrenia patients using varenicline

  This study is testing if the smoking cessation drug varenicline can help people with schizophrenia quit smoking while also managing their movement side effects from antipsychotic medications.

  Recruiting Phase 4 Corporal Michael J. Crescenz VA Medical Center · Philadelphia, Pennsylvania · NCT03495024

• Switching clozapine dosing from twice daily to once daily for schizophrenia

  This study is testing if switching people with schizophrenia from taking clozapine twice a day to once a day can still be effective and easier for them to manage.

  Recruiting Phase 4 Centre for Addiction and Mental Health · Toronto, Ontario · NCT02639702

• Registry of brain network biomarkers in psychosis

  This project will collect MRI, fMRI, blood, and clinical data to try to identify brain connectivity biomarkers in people with schizophrenia or schizoaffective disorder and healthy volunteers.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT01409109

• Effects of exercise on brain health in schizophrenia

  This study is testing if doing aerobic exercise can improve brain health and reduce symptoms in people with schizophrenia and schizoaffective disorder.

  Recruiting BC Mental Health and Addictions Research Institute · Vancouver, British Columbia · NCT01392885

Related topics

Quick answers

How many Schizoaffective Disorder clinical trials are recruiting right now?

32, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 7 countries. The most sites are in United States (22 trials), Canada (4 trials), Germany (2 trials), Singapore (1 trial), China (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 7, Phase 3: 1, Phase 2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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