Investigating brain circuitry related to alcohol use and bipolar disorder
An investigation of reward brain circuitry structure and function in individuals with co-occurring alcohol use disorder and bipolar disorder and their unaffected offspring
This study is looking at how the brain's reward system works in people who have both alcohol use disorder and bipolar disorder, along with their children who don't have these conditions, to help find better treatments for everyone involved.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical University of South Carolina NIH-funded |
| Lab location | 1 site (Charleston, United States) |
| Project ID | NIH-10912002 on NIH RePORTER |
What this research studies
This research focuses on understanding how the brain's reward circuitry functions in individuals who have both alcohol use disorder and bipolar disorder, as well as their unaffected children. By using advanced imaging techniques like functional magnetic resonance imaging (fMRI), the study aims to uncover the structural and functional aspects of the brain that may contribute to these co-occurring conditions. The research will also involve training the investigator in clinical research methods to enhance their ability to conduct impactful studies in this area. Ultimately, the goal is to identify neurobiological targets that could lead to better treatments for these disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with both alcohol use disorder and bipolar disorder, as well as their unaffected offspring.
Not a fit: Patients who do not have alcohol use disorder or bipolar disorder may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for individuals suffering from both alcohol use disorder and bipolar disorder.
How similar studies have performed: Previous research has shown promise in understanding brain circuitry related to mood and substance use disorders, suggesting that this approach could yield valuable insights.
Where this research is happening
Charleston, United States
- Medical University of South Carolina — Charleston, United States (Active)
Researchers
- Principal investigator: Mellick, William — Medical University of South Carolina
- Study coordinator: Mellick, William
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.