Understanding how brain networks relate to decision-making in bipolar disorder
Official title: Establishing Network Neuroscience Mechanisms of Efficiency of Evidence Accumulation in a Well-Characterized Sample with Bipolar Disorder: A Multi-Modal Clinical Imaging Study
Funded at University of Michigan at Ann Arbor · NIH-11300984 · Data updated 2026-11-12
A study of adults with bipolar disorder and healthy controls to see how brain network changes relate to how quickly people gather evidence to make decisions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | June 1, 2022 |
| Project end | March 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $725,194 |
| NIH project number | 5R01MH130348-05 |
| Project ID | NIH-11300984 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with bipolar disorder and healthy adults who can complete brain imaging studies.
✕Less likely to help
Individuals unable to undergo MRI or who are not part of the 130+130 study sample may not benefit.
What this research studies
This project uses brain imaging and advanced network analysis to explore why people with bipolar disorder may accumulate information more slowly or differently when making decisions in complex situations. By comparing 130 healthy adults to 130 adults with bipolar disorder, researchers will examine how flexible brain connectivity supports processing across tasks. The goal is to link brain network dynamics to the efficiency of evidence accumulation and related symptoms like impulsivity. The findings could illuminate brain mechanisms that contribute to mood regulation and decision-making in bipolar disorder and suggest targets for future interventions.
Why it matters
Potential benefit: Better understanding of brain mechanisms in bipolar disorder could lead to improved, more personalized treatments and better symptom management.
How similar studies have gone: Prior research shows a link between brain network flexibility and cognitive processing, but this study applies it specifically to bipolar disorder with multimodal imaging.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Sripada, Chandra Sekhar — University of Michigan at Ann Arbor
- Study coordinator: Sripada, Chandra Sekhar
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.