Condition

Depressive Disorder clinical trials and research

• 45Clinical trials
• 27NIH research projects
• 1New in 30 days
• 18Countries

Newest Depressive Disorder clinical trials

All recruiting trials (45)

• Understanding anxiety, depression, and bipolar disorder over time in China

  This study tests how anxiety, depressive, and bipolar symptoms change over three years to find patterns that help with earlier recognition and prediction in people aged 12–55.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07903246

• Aerobic Exercise as an Adjunct Therapy for Depression

  This study tests whether adding a structured aerobic exercise program to standard antidepressant and therapy helps reduce depression severity more than standard care alone.

  Recruiting Combined Military Hospital Bahawalpur · Chak Eighty-seven -Twelve Left, Punjab Province · NCT07819448

• Group Unified Protocol for Emotional Disorders in adults in public mental health (UP in Spanish)

  A group-based Spanish version of the Unified Protocol is being tested with adults in public mental health to see if it helps anxiety, depression, and related symptoms.

  Recruiting University of La Rioja · Logroño, La Rioja · NCT07682064

• Metformin added to antidepressants for depression with obesity in Pakistani adults

  This study tests whether adding metformin to antidepressant therapy helps reduce depressive symptoms and BMI in adults with depression and overweight/obesity in Pakistan.

  Recruiting at 2 sites Riphah International University · Rawalpindi, Punjab Province and 1 other locations · NCT07654179

• Parent group program using the Unified Protocol for teens with autism and anxiety/depression

  This trial tests a parent-guided adaptation of the Unified Protocol to help adolescents with autism and co-occurring anxiety or depression.

  Recruiting Sahlgrenska University Hospital · Gothenburg · NCT07637799

• Mindfulness‑augmented brain stimulation for treatment‑resistant depression

  This trial will test whether combining fast brain stimulation (iTBS) with a digital mindfulness program helps people with treatment‑resistant depression reduce symptoms and improve thinking.

  Recruiting Phase 2 University of California, San Diego · San Diego, California · NCT07512284

• Digital stepped-care mindfulness program for emotional disorders

  This project tests whether adding an online mindfulness program to usual care helps adults (18–65) with depression, anxiety, OCD, or PTSD recover faster and stay well longer.

  Recruiting Peking University · Beijing · NCT07458100

• Transcutaneous auricular vagus nerve stimulation for depression after heart procedures

  This study tests whether at-home taVNS can help reduce depressive symptoms in adults 18–80 who recently had PCI for ACS.

  Recruiting Tang-Du Hospital · Xi'an, Shaanxi · NCT07454070

• Breathing practices to improve brain and mental health in adolescents

  This project will try a structured breathing program to see if it helps adolescents aged 12–17 who are being treated for anxiety or mild to moderate depression.

  Recruiting at 2 sites Mayo Clinic · Albert Lea, Minnesota and 1 other locations · NCT07369752

• Mapping complex cognitive problems across psychiatric and neurological conditions

  This project will test a set of cognitive tests and optional brain recordings in adults with psychiatric or neurological disorders and healthy volunteers to map high-level thinking problems and how they change over time.

  Recruiting at 2 sites Centre Hospitalier St Anne · Paris and 2 other locations · NCT07295652

• How mental health relates to immunotherapy response in triple-negative breast cancer

  This project tries to see if a patient's mental health affects how well pre-surgery immunotherapy works for people with early triple-negative breast cancer.

  Recruiting Fudan University · Shanghai, Please Select · NCT07290153

• Step-by-step care plan to improve treatment for moderate depression in general practice

  It tests whether a structured step-by-step care plan used by general practitioners works better than usual GP care or psychologist-led behavioral therapy for adults 18–65 with moderate depression.

  Recruiting Aalborg University Hospital · Aalborg · NCT07263321

• Gut microbiome and metabolites in people with IBD and depression

  This project will test whether gut microbes and metabolites differ in adults with IBD who have depression compared with those without depression and with healthy adults.

  Recruiting Qianfoshan Hospital · Jinan, Shandong · NCT07252427

• Accelerated intermittent theta-burst stimulation for depression with post‑COVID‑19 condition

  This will test whether two different schedules of intermittent theta-burst stimulation (accelerated TMS) reduce depressive symptoms and inflammation in adults aged 18–65 who have depressive disorder plus post‑COVID‑19 condition.

  Recruiting Max-Planck-Institute of Psychiatry · Munich, Bavaria · NCT07197138

• Temporal interference stimulation for depressive disorder

  This test tries to see if temporal interference stimulation (TIS) can improve associative memory in adults with depressive disorder.

  Recruiting at 2 sites The Second Hospital of Anhui Medical University · Hefei, Anhui and 1 other locations · NCT07191392

• Developing a gamified app to help 8–12-year-olds with depression manage everyday stressors

  This project will ask children ages 8–12 with increased depressive symptoms and their parents about daily stressors and coping to help design a gamified app that tries to teach emotion regulation.

  Recruiting Ludwig-Maximilians - University of Munich · München, Bavaria · NCT07159347

• Comparing brief psychoanalytic and emotionally focused couple therapies for relationship distress

  This trial will test whether brief psychoanalytic couple therapy or emotionally focused therapy better reduces relationship problems and related depression and anxiety in heterosexual couples with moderate to severe relationship distress.

  Recruiting Beykoz University · Istanbul · NCT07100951

• Personalized online program with human support for women with depression

  A 3D 10-week online CBT program with weekly modules and six coaching sessions is tested as an add-on to usual care to see if it reduces depressive symptoms in women aged 18–45 with moderate depression.

  Recruiting Hospital del Mar Research Institute (IMIM) · Barcelona, Barcelona and 1 other locations · NCT07060690

• Personalized lifestyle support with an app for adults seeing their GP for depression symptoms

  This study tests whether a smartphone app that supports personalized lifestyle changes can help reduce depression symptoms for adults who visit their GP.

  Recruiting at 3 sites Radboud University Medical Center · Nijmegen, Gelderland and 2 other locations · NCT07022184

• Non-invasive ear (auricular) vagus nerve stimulation for depression

  This study will test whether non-invasive ear (auricular) vagus nerve stimulation helps adults with major depressive or bipolar depressive episodes and which biological markers change with treatment.

  Recruiting Max-Planck-Institute of Psychiatry · Munich · NCT07022171

• EL-SHIN: lavender, gratitude, fasting with exercise and light therapy for depressive symptoms

  This trial will see if EL-SHIN—a combined lavender, gratitude, and fasting plus exercise and light therapy program—can help English-speaking adults with moderate depressive, anxiety, and stress symptoms.

  Recruiting Monash University Malaysia · Kuala Lumpur · NCT06995807

• Synbiotic supplement to improve mood and gut health in adults with obesity

  This study will test whether taking a daily synbiotic (prebiotics plus beneficial bacteria) helps mood, gut microbiota, inflammation, appetite, and metabolic markers in adults with obesity who do or do not have anxiety or depression.

  Recruiting Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana · Valencia, Valencia · NCT06901739

• Using Psilocybe Cubensis Mushrooms with or without Fluoxetine for Treatment-Resistant Depression

  This study is testing if taking Psilocybe cubensis mushrooms with or without fluoxetine can help people with treatment-resistant depression feel better.

  Recruiting Phase 1/2 Federal University of Latin American Integration · Foz do Iguaçu, Paraná · NCT06898606

• Exploring body awareness in individuals with depressive disorders

  This study is trying to see how aware people with depression are of their bodies and how this awareness might change during their hospital stay.

  Recruiting Johannes Kepler University of Linz · Linz · NCT06879977

• Comparing Islamic and Standard Hypnotherapy for Anxiety and Depression

  This study is testing whether a special type of hypnotherapy that incorporates Islamic principles can help Muslim adults with anxiety and depression feel better compared to standard hypnotherapy.

  Recruiting Istanbul Nisantasi University · Istanbul · NCT06844058

• Music therapy for teens with emotional challenges

  This study tests if a music therapy program can help teenagers aged 13-18 who are dealing with depression and anxiety feel better.

  Recruiting Oslo University Hospital · Oslo, Nydalen · NCT06733883

• Internet-based treatment for anxiety and depression in adolescents

  This study is testing an online treatment for anxiety and depression in Romanian teenagers aged 13-17 to see if it helps them feel better and to find out which teens are most likely to benefit from it.

  Recruiting Babes-Bolyai University · Cluj-Napoca and 1 other locations · NCT06724666

• Testing a new drug for treatment-resistant depression

  This study is testing a new drug called HNK to see if it can help people with treatment-resistant depression feel better when other medications haven't worked.

  Recruiting Phase 2 National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT06511908

• A program to help young adults from minority groups engage with mental health services

  This study is testing a new program designed to help young adults from minority backgrounds connect better with mental health services by adding cultural insights and creative arts therapy.

  Recruiting New York University · The Bronx, New York · NCT06508450

• Investigating the effects of citalopram on brain response to emotions

  This study tests how the antidepressant citalopram affects the brain's response to emotions in healthy people by comparing brain scans after taking the medication or a placebo.

  Recruiting University of Oxford · Oxford, Oxfordshire · NCT06412315

• A platform for collecting data on mood disorders

  This study is trying to create a better way to collect information from people with mood disorders like depression and bipolar disorder to help find new treatments that work for them.

  Recruiting at 9 sites St. Joseph's Healthcare Hamilton · Calgary, Alberta and 8 other locations · NCT06408012

• Oh Happy Day Class – Digital Connections for Depression in African Americans

  A mobile app delivers six weekly depression-therapy classes to African American adults to see if it helps reduce depressive symptoms.

  Recruiting University of Wisconsin, Madison · Madison, Wisconsin · NCT06206226

• Using brain stimulation to treat depression in older adults

  This study is testing if a brain stimulation treatment can help older adults with depression who haven't found relief from regular medications.

  Recruiting Taipei Veterans General Hospital, Taiwan · Taipei · NCT06187454

• Testing psilocybin's effects on brain activity in depression

  This study is testing if psilocybin can change brain activity linked to mood in people with major depression to see if it helps them feel better.

  Recruiting Phase 2 Sunnybrook Health Sciences Centre · Toronto, Ontario · NCT06072898

• Community Connections for treating emotional disorders in youth

  This study is testing a new therapy program for kids and teens with anxiety and depression to see if it helps them feel better, and it involves both the youth and their parents.

  Recruiting University of Miami · Coral Gables, Florida · NCT06038721

• Evaluating Ketamine Treatment Plans for Chronic Conditions

  This study is testing different ways to use Ketamine for people with chronic pain, depression, and anxiety to see how well it works and if combining it with therapies like talk therapy or music helps improve their conditions.

  Recruiting RIVER Foundation · Helena, Montana · NCT06038409

• Modified Dialectical Behavior Therapy for Treating Anxiety and Depression

  This study is testing a new type of therapy called modified Dialectical Behavior Therapy to see if it can help people with anxiety and depression feel better and improve their quality of life.

  Recruiting Mackay Memorial Hospital · Taipei · NCT05989451

• Developing a group treatment to help teens at risk for serious mental illness

  This study is testing a new group program to help high school students with mild signs of depression or anxiety build resilience and prevent serious mental health issues.

  Recruiting Massachusetts General Hospital · Boston, Massachusetts · NCT05962879

• Psychotherapy to improve brain function and reduce suicidality in older adults

  This study is testing a new therapy called Engage & Connect to see if it can help older adults with depression and suicidal thoughts by improving their brain function and encouraging social connections.

  Recruiting Weill Medical College of Cornell University · New York, New York · NCT05925322

• Predicting mood episode recurrence in bipolar and depressive disorders

  A wearable-based study to see if heart rate, sleep, activity, and mood data from a smartwatch can help predict when manic or depressive episodes will come back in people with bipolar or depressive disorders.

  Recruiting National Taiwan University Hospital · Taipei · NCT05828056

• Examining how AMPA receptor blockade affects Ketamine's ability to reduce suicidal thoughts

  This study is testing if a medication called perampanel can improve the effects of Ketamine in reducing suicidal thoughts and depression in people with major depressive disorder, bipolar disorder, or PTSD.

  Recruiting Phase 2 Yale University · West Haven, Connecticut · NCT05786066

• OSU6162 for patients with depression not helped by standard treatments

  This study is testing if a new medication called OSU6162 can help people with depression who haven't found relief from standard treatments.

  Recruiting at 2 sites Phase 2 Göteborg University · Lund, Skåne County and 3 other locations · NCT05641623

• Understanding children's emotions in therapy

  This study is testing a new therapy approach for kids aged 8 to 15 with anxiety, depression, trauma, or behavior issues to see if it helps them feel better compared to those who aren't receiving treatment right away.

  Recruiting at 2 sites University of Guelph · Guelph, Ontario and 1 other locations · NCT05637320

• Cognitive-behavioral therapy and exercise training for teenage girls at risk for type 2 diabetes

  This study is testing if cognitive-behavioral therapy, exercise training, or both can help teenage girls at risk for type 2 diabetes improve their health and reduce stress and depression.

  Recruiting at 2 sites Colorado State University · Aurora, Colorado and 1 other locations · NCT05543083

• Evaluating the effects of electroconvulsive therapy on depression

  This study is testing how electroconvulsive therapy can help people with major depression feel better and what effects it might have on their thinking over six months.

  Recruiting at 2 sites Haukeland University Hospital · Bergen and 1 other locations · NCT05388461

NIH-funded research (27)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Psilocybin-Assisted ACT for Co-Occurring Cocaine Use Disorder and Major Depressive Disorder

  A new treatment combines psilocybin with Acceptance and Commitment Therapy to help people who have both cocaine use disorder and major depressive disorder.

  NIH research University of Texas Hlth Sci Ctr Houston · Houston, United States · NIH-11458025

• Single-cell study of mood-regulation brain circuits in depression

  A large study will map which genes and cell types in mood-related brain circuits are linked to major depressive disorder, including differences by ancestry and sex.

  NIH research Centre de Recherche de L'hopital Douglas · Montreal, Canada · NIH-11421431

• Single-cell map of mood circuits in major depressive disorder

  Researchers will map the tiny brain cells in mood-control areas to understand how genes and cell types relate to depression, with attention to ancestry and sex.

  NIH research Lieber Institute, INC. · Baltimore, United States · NIH-11418004

• Making genetic research clearer to find genes linked to major depression

  Researchers will use health records and genetic data to pinpoint genes that drive major depression, aiming to help people with depression get better-targeted treatments.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11417203

• How iTBS and a brain drug could boost brain wiring to help depression

  A study tests whether a brain-stimulating treatment (iTBS) works by improving brain plasticity and whether adding a drug (DCS) enhances this effect for people with major depressive disorder.

  NIH research Mclean Hospital · Belmont, United States · NIH-11337250

• Portable, low-cost genetic test to guide antidepressant choices

  This project is creating a small, affordable device that rapidly reads genes that affect how people with major depressive disorder process antidepressants to help choose safer, more effective medicines.

  NIH research University of Virginia · Charlottesville, United States · NIH-11309190

• Psilocybin paired with cognitive behavioral therapy for adults with depression

  This project combines two supervised psilocybin sessions with 12 sessions of cognitive behavioral therapy for adults living with major depressive disorder.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11248770

• Genetic subtypes of major depression

  This project looks at whether people with major depression can be grouped by their genetics to better understand different forms of the condition for people of different ages and ancestries.

  NIH research University of Colorado · Boulder, UNITED STATES · NIH-11219386

• Mapping cell and gene changes in the brain linked to depression

  Mapping genes and cell types in key mood-regulating brain regions from people with major depressive disorder, including diverse ancestries and both sexes.

  NIH research Centre de Recherche de L'hopital Douglas · Montreal, Canada · NIH-11184481

• Single-cell map of mood-regulating brain regions in depression

  Researchers will make a detailed cellular map of key brain areas that control mood to find molecular changes linked to major depression and how these vary by ancestry and sex.

  NIH research Lieber Institute, INC. · Baltimore, United States · NIH-11184427

• A portable system for quick genetic testing in patients with major depression

  This study is working on a handy, affordable tool that helps quickly check how your genes might affect how well certain depression medications work for you, so you can get the right treatment faster and with fewer side effects.

  NIH research University of Virginia · Charlottesville, United States · NIH-11145799

• Investigating the role of VGF in Alzheimer's disease and depression

  This study is looking at how late-onset Alzheimer's disease and depression are connected, focusing on a protein called VGF that might play a role in both, to help find better ways to treat these conditions.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11135944

• How inflammation affects the brain in people with major depressive disorder

  This study is looking at how long-lasting inflammation in the body might affect people with depression, and it involves giving participants an injection to see how their bodies and brains respond, so we can better understand the connection between inflammation and mental health.

  NIH research Laureate Institute for Brain Research · Tulsa, United States · NIH-11079531

• Using psilocybin with therapy to treat major depression

  This study is looking at how combining psilocybin, a natural psychedelic, with talk therapy can help adults with major depression feel better, and it involves two sessions with psilocybin and 12 therapy sessions to see if this mix works well and is safe.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11038055

• Investigating a new target for treating major depressive disorder using brain imaging

  This study is looking at how a brain protein called VAChT might be connected to the severity of major depressive disorder, using special imaging to see its levels in the brain, with the hope of finding new ways to help people with depression.

  NIH research State University New York Stony Brook · Stony Brook, United States · NIH-10950488

• Understanding how genetics and sex affect alcohol use disorders and depression

  This study is looking at how our genes might affect problems with alcohol use and depression, especially how these factors differ between men and women, to help improve understanding and treatment for people dealing with these issues.

  NIH research Virginia Commonwealth University · Richmond, United States · NIH-10949853

• Understanding how brain cells contribute to major depressive disorder

  This study is looking at how certain brain cells might be involved in major depressive disorder to help understand the condition better and find new ways to treat it for people who are struggling with depression.

  NIH research James J Peters VA Medical Center · Bronx, United States · NIH-10948932

• The link between gut bacteria and major depressive disorder.

  This study is looking at how changes in gut bacteria might affect depression, and it's for people with major depressive disorder who want to understand more about how their gut health could be linked to their mood.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-10908335

• Investigating how microRNAs affect major depressive disorder

  This study is looking at tiny molecules in the brain that might help explain why some people experience major depressive disorder, with the hope of finding new ways to treat it.

  NIH research University of Arizona · Tucson, United States · NIH-10893026

• Using smartphone and wearable data to track changes in depression symptoms

  This study is looking at how smartphone and wearable device data can help track changes in symptoms for people with major depressive disorder, so if you're an adult seeking treatment, you could help us learn more about your mood and behaviors over 90 days to improve personalized care.

  NIH research Dartmouth College · Hanover, United States · NIH-10854971

• Using magnetic stimulation to treat depression and pain together

  This study is looking at a new way to help people with both depression and chronic pain by using a special treatment called rTMS, which targets different parts of the brain to improve mood and reduce pain.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-10817712

• Identifying different types of major depressive disorder using data analysis

  This study is looking at different types of major depressive disorder to find better ways to treat people who haven't had success with usual therapies, so they can get more personalized and effective help.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-10808944

• Understanding how glutamate metabolism affects major depressive disorder

  This study is looking at how a brain chemical called glutamate works in people with depression, hoping to find better ways to treat it with faster-acting medications.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-10795901

• Combining esketamine with cognitive behavioral therapy for hospitalized patients with depression and suicidal thoughts

  This study is looking at how well combining a fast-acting depression medication called esketamine with talk therapy can help people who are in the hospital because they are feeling suicidal, aiming to see if this mix can improve their mood and keep them safe after they leave.

  NIH research Yale University · New Haven, United States · NIH-10688291

• Testing a new brain stimulation technique for teens with suicidal thoughts and depression

  This study is looking at a new way to help teenagers who are feeling very depressed and having thoughts of suicide by using a special brain stimulation technique, and it aims to see if this treatment can improve their mood and reduce those thoughts.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-10685343

• Combining heat therapy and behavioral therapy to treat major depression

  This study is looking at how well a combination of whole-body heating and talk therapy can help people with major depression feel better quickly and improve their mood over time.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-10640897

• Investigating brain activity related to memory recall in families with major depression

  This study is looking at how the brain reacts when people remember personal experiences to see if it can help predict who might develop depression, especially in young adults with a family history of the condition.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-10558686

Related topics

Quick answers

How many Depressive Disorder clinical trials are recruiting right now?

45, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 18 countries. The most sites are in United States (11 trials), China (6 trials), Canada (3 trials), Spain (3 trials), Taiwan (3 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 5, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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