Understanding the link between exercise and mood in bipolar disorder

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to explore the relationship between physical activity, sleep, and mental health in individuals with and without mood disorders. Participants aged 12 to 60 will engage in a two-year study where they will complete electronic diaries and wear activity monitors to track their movement and mood. The study will include individuals with bipolar disorder, major depression, and healthy relatives, allowing researchers to assess the impact of motor activity on mood states. The goal is to replicate previous findings and further characterize the associations between these factors.

Why it matters

Who can join: the full rules

* INCLUSION CRITERIA:

To be eligible to participate in this study, an individual must meet all of the following criteria:

1. Stated willingness to comply with all study procedures and availability for the duration of the study
2. Aged 8 and older
3. Probands must have at least one first-degree relative agree to participate
4. Affected probands must have a lifetime history of a mood disorder
5. Unaffected probands must have no lifetime history of a mood disorder
6. In good general health as evidenced by medical history
7. Agreement to adhere to Lifestyle Considerations throughout study duration
8. Ability of subject (or Legally Authorized Representative (LAR)) to understand and the willingness to sign a written informed consent document.

EXCLUSION CRITERIA:

The presence of certain medical conditions may interfere with the interpretation or increase risk of medical complications of the assessments including exercise. Therefore, an individual who meets any of the following criteria will be excluded from participation in this study:

1. Pregnancy
2. People in acute episodes of mania or depression (not excluded, but will delay study entry until sufficiently managed to allow participation in study procedures).

Where it's running

• National Institutes of Health Clinical Center
  Bethesda, Maryland, United States Recruiting

Study contacts

• Principal investigator: Kathleen R Merikangas, Ph.D. — National Institute of Mental Health (NIMH)
• Study coordinator: Kathleen R Merikangas, Ph.D.
• Email: familystudy@nih.gov
• Phone: (301) 496-7773

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.