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Clinical trials and research at Karolinska Institutet

• 179Clinical trials
• 6New in 30 days
• 22Countries

Newest trials

All recruiting trials (newest 150 of 179)

• Cognitive Rehabilitation of Everyday Goals With GMT: How Different Ways of Delivery Work

  This study tests Goal Management Training to see if a Swedish version helps adults with acquired brain injury or chronic pain improve practical goal-directed thinking and daily functioning.

  Recruiting at 2 sites Karolinska Institutet · Luleå, Norrbotten County and 2 other locations · NCT07924774

• Sensory nerve tests after finger nerve injury

  This study tests whether neurophysiological measurements can reflect finger sensation changes after digital nerve injury, using patients as their own controls.

  Recruiting Karolinska Institutet · Stockholm and 1 other locations · NCT07904286

• National Highly Specialized Care for Severe Self-Harm and Eating Disorders in Swedish Youth

  This observational study tests how well NHV, a highly specialized care program, works for children and teens with severe self-harm or eating disorders by asking patients and their parents about their experiences and what changes they notice.

  Recruiting at 2 sites Karolinska Institutet · Stockholm and 1 other locations · NCT07898059

• Specialist Supportive Clinical Management for teens with anorexia or atypical anorexia

  This study tests a teen-focused SSCM approach to help 13-17 year-olds with anorexia nervosa or atypical anorexia nervosa when other treatments haven’t worked or can’t be used.

  Recruiting Karolinska Institutet · Stockholm · NCT07893145

• National Highly Specialized Care for adults with treatment-resistant self-harm and eating disorders (Substudy 1)

  This study tests how people with severe, hard-to-turge self-harm or eating disorders in Sweden experience NHV care and whether the treatment helps with symptoms and daily functioning.

  Recruiting at 2 sites Karolinska Institutet · Stockholm and 1 other locations · NCT07878897

• Modified ketogenic diet for adults with drug-resistant epilepsy

  This study tests whether a modified ketogenic diet can help adults with drug-resistant epilepsy see fewer seizures and feel better overall.

  Recruiting Karolinska Institutet · Stockholm · NCT07878104

• Mobilisation After Endovascular Stroke Treatment

  This study checks whether moving around 12 hours after endovascular stroke treatment is as safe as moving around 24 hours for people with an acute ischemic stroke.

  Recruiting at 2 sites Karolinska Institutet · Tampere and 1 other locations · NCT07860333

• Risk of cervical cancer after HPV detection in healthy women

  This study tests how likely it is for cervical cancer to develop after different HPV detection patterns in healthy women who undergo HPV-based screening.

  Recruiting Karolinska Institutet · Stockholm · NCT07850128

• Gene-based grouping of bone and soft tissue tumors

  This study tests whether tumors of bone and soft tissue can be sorted into clearer genetic groups using DNA and RNA data.

  Recruiting Karolinska Institutet · Stockholm · NCT07822204

• Digital parenting programs with or without emotion-regulation for anger in parenting

  This pilot randomized trial tests two online parenting programs, with and without emotion-regulation training, to see if they are doable, acceptable, and potentially helpful for parents who get angry while managing a child.

  Recruiting Karolinska Institutet · Stockholm · NCT07795684

• Pain Reprocessing Therapy in a Specialist Pain Clinic

  This study tests Pain Reprocessing Therapy (PRT) to see if it can be feasibly used and how patients feel about it in a pain rehabilitation clinic for adults with chronic nociplastic or mixed pain.

  Recruiting Karolinska Institutet · Stockholm · NCT07791355

• Preserving muscle during weight loss with incretin therapy

  This study tests whether unilateral resistance training can help maintain skeletal muscle while women with obesity start incretin-based obesity medicine.

  Recruiting Karolinska Institutet · Stockholm, Stockholm County · NCT07761923

• Blended ERITA for Teens Who Self-Injure

  A blended, youth-focused therapy test combines in-person sessions with digital tools to help teens who have recently self-injured see if this approach improves emotion regulation and daily functioning.

  Recruiting Karolinska Institutet · Stockholm · NCT07755774

• Compare carbon emissions in two orthopedic surgery settings using different materials

  This study tests whether two different operating room setups and material choices produce different CO2 emissions for common hand and foot surgeries.

  Recruiting Karolinska Institutet · Stockholm · NCT07657039

• Dog-allergy immunotherapy with Alutard SQ Dog in Swedish practice

  This study tests whether Alutard SQ Dog immunotherapy helps adults with moderate-to-severe dog allergy when used in real-world Swedish care.

  Recruiting at 2 sites Phase 4 Karolinska Institutet · Lund, Skåne County and 1 other locations · NCT07651891

• Dementia with Lewy Bodies: Symptoms, Biomarkers and Progression

  This study tests how well clinical features, biological markers, and brain scans distinguish DLB and its early stages in patients seen at Stockholm clinics.

  Recruiting Karolinska Institutet · Stockholm · NCT07629349

• Walking and Thinking: Brain Activity During Complex Walking After Stroke

  This study looks at how the brain works during tricky walking tasks in people who have had a stroke to understand motor and thinking together in real life movement.

  Recruiting Karolinska Institutet · Solna, Stockholm County · NCT07624630

• GEARS: Group Therapy for Emotion Regulation in Adults with ADHD

  This trial tests the GEARS group therapy to see if it helps adults with ADHD manage their emotions better compared with a waitlist control.

  Recruiting Karolinska Institutet · Stockholm · NCT07614867

• Restory: an online, anonymous trauma therapy for adults affected by sexual abuse

  A free, anonymous online therapy program called Restory tests whether it helps reduce PTSD symptoms in adults who experienced sexual abuse, compared with a waitlist control.

  Recruiting Karolinska Institutet · Stockholm · NCT07610187

• Unloaded Minds: How Two Weeks of Unloading Affects Brain and Movement in Lunar Gravity

  This study tests how two weeks of unloading one leg changes the brain’s movement programs and how well nerves and muscles work together, then sees how movement feels when walking in simulated lunar gravity.

  Recruiting Karolinska Institutet · Huddinge, Stockholm County · NCT07607340

• Precision-Based Primary Care for Musculoskeletal Pain

  This study tests whether the Start-MSK screening tool can help primary care clinicians tailor care for adults with musculoskeletal pain to improve outcomes.

  Recruiting Karolinska Institutet · Stockholm · NCT07603674

• Does preoperative physical activity help predict perioperative problems after non-cardiac surgery?

  This study tests whether self-reported physical activity before surgery adds to existing risk factors in predicting complications and death after elective non-cardiac surgery.

  Recruiting Karolinska Institutet · Stockholm · NCT07603622

• Feasibility of a 10-week self-guided digital program for functional hypothalamic amenorrhea

  This pilot test checks whether a 10-week, self-guided web program for FHA is doable and acceptable for women, to pave the way for a larger trial.

  Recruiting at 2 sites Karolinska Institutet · Stockholm, Stockholm County and 1 other locations · NCT07589868

• Tracking physical activity changes in people with Parkinson's

  This project will follow about 450 people with Parkinson's over four years using wearable activity monitors, clinical tests, and questionnaires to see which physical, cognitive, social, or environmental factors make people less active.

  Recruiting Karolinska Institutet · Stockholm · NCT07585409

• Digital program to help people with COPD manage their symptoms

  This project will test a smartphone app combined with home spirometry to help adults with COPD who had at least one exacerbation in the past year manage their condition over six months.

  Recruiting Karolinska Institutet · Solna, Stockholm County · NCT07573098

• Internet-delivered Emotion Regulation Therapy for Adolescents with NSSI

  This trial tests whether a flexible, internet-based therapy for teens who self-injure can be more effective than standard online treatment for reducing nonsuicidal self-injury symptoms.

  Recruiting Karolinska Institutet · Stockholm · NCT07573085

• Brief Cognitive Behaviour Therapy to Prevent Suicide Reattempts in Swedish Psychiatric Inpatient Care

  This study tests whether four brief CBT sessions can be delivered during a psychiatric hospital stay to help adults who recently attempted suicide or are at high risk see if the treatment works and is easy to use in routine care.

  Recruiting Karolinska Institutet · Stockholm · NCT07567885

• Microbiome and metabolome profiles in couples having IVF

  This will test whether partners' microbiome and metabolome profiles are linked to fertilization, pregnancy, and live birth in couples having IVF.

  Recruiting at 3 sites Karolinska Institutet · Malmö and 2 other locations · NCT07532629

• Nationwide Swedish program testing donor-derived cell-free DNA to monitor rejection after heart transplant

  This project tests whether a blood test measuring donor-derived cell-free DNA can help monitor rejection in adults who have had a heart transplant.

  Recruiting Karolinska Institutet · Stockholm · NCT07531784

• Carbon footprint comparison of surgery versus non-surgical care for metacarpal shaft fractures

  This study will test whether surgery or non-surgical care for adults with metacarpal shaft fractures produces more carbon emissions over the year after injury.

  Recruiting Karolinska Institutet · Stockholm, Stockholm County · NCT07521943

• Personalised Tamoxifen Dose to Improve Treatment in Early-Stage Breast Cancer

  This trial tests whether adjusting tamoxifen doses based on how each patient metabolizes the drug can improve outcomes for women with early-stage hormone receptor–positive breast cancer.

  Recruiting at 2 sites Phase 3 Karolinska Institutet · Borås and 3 other locations · NCT07502820

• Potassium-friendly plant-based diet for people with advanced CKD

  This pilot study tests whether a liberal plant-based diet with normal potassium levels is safe and acceptable for adults with advanced CKD (eGFR <30) who are not on dialysis.

  Recruiting Karolinska Institutet · Huddinge, Stockholm Län · NCT07494266

• Inorganic nitrates for intermediate high-risk pulmonary embolism

  This test gives nitrate-rich beetroot juice to see if lowering lung artery pressure helps people with intermediate high‑risk pulmonary embolism who have signs of right‑heart strain.

  Recruiting Karolinska Institutet · Stockholm and 1 other locations · NCT07431229

• Comparing fruit stands alone versus fruit stands plus an awareness campaign in schools

  This project will test whether putting fruit stands in schools, with or without a health-awareness campaign, helps Swedish students aged 7–19 eat more fruit.

  Recruiting at 2 sites Karolinska Institutet · Stockholm and 1 other locations · NCT07385820

• Metacognitive Therapy vs Cognitive-Behavioral Therapy for Anxiety Disorders

  This study asks people with generalized anxiety disorder, social anxiety disorder, or PTSD to share their experiences after trying metacognitive therapy or disorder-specific cognitive-behavioral therapy in a randomized trial.

  Recruiting Karolinska Institutet · Stockholm · NCT07382323

• Metacarpal shaft fractures: operative fixation versus immediate unrestricted mobilization

  It tests whether immediate unrestricted mobilization (no surgery) provides similar one-year outcomes to operative fixation for adults with displaced spiral or oblique metacarpal shaft fractures.

  Recruiting Karolinska Institutet · Stockholm, Stockholm County · NCT07357493

• Yoga-based Movements for Primary Headaches (YOURHEAD)

  A yoga-based movement program is being tested to see if it can help reduce headaches and improve quality of life for adults with migraine and/or cluster headaches.

  Recruiting Karolinska Institutet · Huddinge · NCT07348783

• Internet-delivered gut-directed hypnotherapy versus iCBT for stomach pain in children and teens

  This trial will test whether online gut-directed hypnotherapy or internet-based cognitive behavioral therapy helps children and adolescents (8–17) with IBS, functional abdominal pain, or functional dyspepsia reduce stomach pain and improve daily life.

  Recruiting Karolinska Institutet · Stockholm · NCT07319078

• Using regular client feedback (FIT) to improve outcomes in social services

  This project will test whether using regular client feedback with FIT helps people receiving social services—such as outpatient, addiction, and residential care—get better, more tailored support.

  Recruiting Karolinska Institutet · Linköping · NCT07303608

• Group-based Metacognitive Therapy for PTSD in routine psychiatric care.

  This project will try group-based Metacognitive Therapy (MCT) for adults with PTSD to see if people accept the treatment and whether symptoms and quality of life improve when it is offered in routine psychiatric care in Sweden.

  Recruiting Karolinska Institutet · Stockholm · NCT07302334

• Suprazygomatic maxillary nerve block to reduce pain and shorten hospital stay after cleft palate repair in children

  This project tries a suprazygomatic maxillary nerve block in children having cleft palate repair to see if they need less morphine and can go home sooner.

  Recruiting Karolinska Institutet · Stockholm · NCT07279883

• HPV self-sampling to improve cervical screening for women in Zaporizhzhia during the war

  This project will test whether giving women aged 30–60 in Zaporizhzhia HPV self-sampling kits can keep cervical screening going when clinic access is disrupted by the war.

  Recruiting Karolinska Institutet · Zaporizhzhya · NCT07275333

• Epilepsy and gut and mouth bacteria: linking microbiota to seizure medicine response

  This project will test whether differences in gut and mouth bacteria are linked to epilepsy type and change how well seizure medicines work in people newly diagnosed with epilepsy compared with healthy volunteers.

  Recruiting at 6 sites Karolinska Institutet · Gothenburg and 5 other locations · NCT07253701

• Surgery first versus IVF-first for people with advanced endometriosis

  This trial will test whether having surgery before assisted reproductive technologies (like IVF) or going straight to IVF gives people with advanced endometriosis a better chance of pregnancy and live birth.

  Recruiting Karolinska Institutet · Stockholm, Stockholm County and 3 other locations · NCT07240363

• Same-day discharge after robotic-assisted hysterectomy

  This will see if people having robotic-assisted hysterectomy for benign conditions or endometrial cancer can safely go home the same day instead of staying overnight.

  Recruiting at 3 sites Karolinska Institutet · Stockholm and 2 other locations · NCT07233811

• Lifestyle program to lower heart and metabolic risk in people with obsessive-compulsive disorder

  This program will test whether a group lifestyle intervention helps adults with OCD become more physically active and lower their cardiometabolic risk.

  Recruiting Karolinska Institutet · Huddinge, Stockholm County · NCT07206212

• Choosing between two online cognitive behavioral programs for generalized anxiety

  This study tests whether adults with generalized anxiety do better, stick with treatment more, and feel more satisfied when they can choose between two internet-based CBT programs versus being randomly assigned, and whether matching a psychologist's prediction improves results.

  Recruiting Karolinska Institutet · Stockholm, Sverige · NCT07201844

• Postpartum program to prevent cardiometabolic problems after preeclampsia

  This study will test a 9-month app-based support program to lower blood pressure and help with weight loss in first-time mothers who recently had preeclampsia.

  Recruiting at 2 sites Karolinska Institutet · Stockholm, Stockholm County and 1 other locations · NCT07199283

• Global look at how cancer affects appearance

  This project will see how adults with advanced cancer from eight countries notice and feel about weight loss.

  Recruiting Karolinska Institutet · Stockholm · NCT07195448

• Thumb-base joint replacement for osteoarthritis

  This trial tries replacing the thumb-base (CMC-1) joint with a prosthesis to reduce pain and improve hand strength in people with thumb-base osteoarthritis who have not had enough relief from non-surgical care.

  Recruiting Karolinska Institutet · Stockholm · NCT07178223

• Early double sequential defibrillation for cardiac arrest outside the hospital

  We test whether using two defibrillators in quick succession after the first failed shock helps adults with out‑of‑hospital cardiac arrest and a shockable rhythm survive more often than continuing standard single shocks.

  Recruiting at 9 sites Phase 2/3 Karolinska Institutet · Amsterdam and 13 other locations · NCT07174986

• Risk patterns before a crime among people undergoing forensic psychiatric evaluation

  This study tests whether there are identifiable risk patterns in people who will have a forensic psychiatric evaluation after a crime, by comparing those whose records were requested for evaluation with similar patients who were not.

  Recruiting Karolinska Institutet · Stockholm · NCT07162909

• Red blood cells and heart protection in people with diabetes

  This project tests whether red blood cells help protect the heart after a heart attack and how they are changed in people with type 2 diabetes.

  Recruiting Karolinska Institutet · Stockholm, Swsden · NCT07151222

• App-based tool to teach and train correct inhaler technique

  This trial will test whether an app helps people aged 16 and older with asthma or COPD use their inhalers correctly over a 6–12 week period compared with standard education.

  Recruiting at 3 sites Karolinska Institutet · Uppsala, Uppsala County and 2 other locations · NCT07145632

• Contactless imaging to detect early skin microangiopathy in type 1 diabetes

  This project will test whether a contactless imaging device (TCI P4) can measure skin microcirculation differences in people with type 1 diabetes compared with healthy volunteers.

  Recruiting Karolinska Institutet · Danderyd, Stockholm County · NCT07145567

• Immune response in neck lymph nodes of people with head and neck cancer.

  This project will test whether immune and genetic differences between the primary tumor and nearby neck lymph nodes, including sentinel nodes, indicate whether cancer has spread in people with HNSCC.

  Recruiting Karolinska Institutet · Stockholm, Stockholm County · NCT07131566

• Predicting airway problems in children with tracheostomies using caregiver and pediatrician reports.

  We will see if symptoms reported by caregivers or pediatricians can predict airway complications found during routine surveillance endoscopy in children with tracheostomies.

  Recruiting Karolinska Institutet · Solna · NCT07121517

• Surfactant given through a laryngeal mask for preterm babies with RDS in Vietnam

  For preterm babies under 34 weeks with respiratory distress, the team will try giving surfactant through a soft throat mask (SALSA) instead of an endotracheal tube (INSURE) to see if it reduces the need for invasive breathing support.

  Recruiting Karolinska Institutet · Hanoi · NCT07098910

• 5-day intensive trauma-focused program for adolescents with PTSD

  This project will try a Swedish 5-day intensive program combining EMDR, trauma-focused CBT elements, physical activity, and caregiver support for adolescents (13–17) with PTSD to see if symptoms improve quickly and more teens complete treatment.

  Recruiting Karolinska Institutet · Stockholm · NCT07052474

• Swedish heart and kidney failure pilot

  This trial will test whether the drug eplerenone is safe and feasible for people with heart failure with reduced ejection fraction who also have severe chronic kidney disease.

  Recruiting Phase 2 Karolinska Institutet · Stockholm · NCT07029503

• Choosing Wisely recommendations for care in the intensive care unit

  This project will try the Choosing Wisely approach in adult ICU patients in Sweden to see if using fewer unnecessary tests and interventions is safe.

  Recruiting at 2 sites Karolinska Institutet · Stockholm and 1 other locations · NCT07013175

• Rapid high-sensitivity Troponin I testing in ambulance care

  This tests whether a rapid high-sensitivity troponin I blood test used by ambulance crews helps identify heart attacks earlier in people with chest pain or suspected myocardial infarction.

  Recruiting Karolinska Institutet · Stockholm, Årsta · NCT07008391

• Routine versus selective bile-duct imaging during gallbladder removal

  This trial will test whether routinely taking X-ray images of the bile ducts during gallbladder removal or only doing them when needed leads to fewer complications for adults having gallbladder surgery without suspected bile duct stones.

  Recruiting Karolinska Institutet · Stockholm · NCT07002619

• Psychosocial support for young cancer patients

  This study is testing a new support program for young cancer patients in Sweden to see if it helps them manage stress and build resilience after their diagnosis.

  Recruiting at 2 sites Karolinska Institutet · Gothenburg and 1 other locations · NCT06979843

• Analyzing saliva proteins in young children to assess caries risk

  This study looks at the saliva of 3-year-old children to see if certain proteins can help predict their risk of developing cavities.

  Recruiting Karolinska Institutet · Stockholm · NCT06957509

• Lowering blood pressure by adding stair climbing to brisk walking

  We will test whether adding short daily stair climbing to a brisk-walking program lowers systolic blood pressure in adults 35 and older who have high blood pressure, are overweight, and are not regularly active.

  Recruiting Karolinska Institutet · Stockholm and 3 other locations · NCT06952348

• Transdiagnostic metacognitive therapy versus disorder-specific cognitive-behavioral therapy for adult anxiety

  This tests whether transdiagnostic metacognitive therapy works better than disorder-specific cognitive-behavioral therapy for adults with generalized anxiety disorder, social anxiety disorder, or PTSD.

  Recruiting Karolinska Institutet · Stockholm · NCT06937892

• SAFETY family-based program for youths after a suicide attempt

  This project will test whether the SAFETY family-based therapy helps 10-17-year-olds who recently attempted suicide avoid repeat attempts.

  Recruiting at 4 sites Karolinska Institutet · Helsingborg and 4 other locations · NCT06931639

• Improving safe and person-centered care during childbirth

  This study is testing a new way to improve communication and teamwork during childbirth to see if it makes the experience safer and better for mothers and babies.

  Recruiting at 7 sites Karolinska Institutet · Halmstad, Halland County and 6 other locations · NCT06926504

• Examining brain activity during complex walking in people with atypical Parkinsonian syndromes

  This study looks at how brain activity changes when people with atypical Parkinsonian syndromes, like PSP and MSA, try to walk in different ways to help improve their independence.

  Recruiting Karolinska Institutet · Solna, Solna · NCT06906276

• Anaesthesia risks during airway endoscopy for children with a tracheostomy

  We will see how often children with a tracheostomy have serious anesthesia problems when they undergo surveillance airway endoscopy.

  Recruiting Karolinska Institutet · Solna · NCT06906263

• Step-by-Step: Stepped care for children with defiant or aggressive behavior

  This project tests a stepped care program for families of 8–16-year-olds with defiant or aggressive behavior, starting with an online parenting course and adding virtual-reality–assisted CBT for the child or parent or usual clinic care if more help is needed.

  Recruiting Karolinska Institutet · Solna · NCT06902649

• Exploring physical activity in people with Parkinson's disease

  This study looks at how physical activity changes for people with Parkinson's disease in different situations to see what affects their activity levels and how to create better support for them.

  Recruiting Karolinska Institutet · Stockholm, Solna · NCT06901869

• Feeding problems and quality of life in children with a tracheostomy tube

  The team will see if feeding and swallowing problems are linked to how children with tracheostomy tubes and their parents rate the child's quality of life.

  Recruiting Karolinska Institutet · Solna, Stockholm County and 1 other locations · NCT06893458

• Immediate effects of spinal manipulation, exercise, and placebo on movement in chronic low back pain

  This project will try a single session of spinal manipulation, targeted trunk exercises, and an open-label placebo to see which produces immediate improvements in movement and pain for adults with chronic non-specific low back pain.

  Recruiting Karolinska Institutet · Huddinge · NCT06891625

• Vitamin mix for glaucoma patients

  This study is testing if a mix of certain vitamins can help protect the eyes and slow vision loss in people with glaucoma.

  Recruiting Karolinska Institutet · Stockholm, Stockholm County and 1 other locations · NCT06885827

• Psychological support program for forcibly displaced youth

  This study is testing a new psychological support program for young people who have been forced to leave their homes to see if it helps them feel better compared to regular care.

  Recruiting Karolinska Institutet · Stockholm · NCT06878092

• Identifying brain connectivity changes in Alzheimer's disease

  This study is trying to see if changes in how different parts of the brain connect can help predict who might develop Alzheimer's disease and how treatments might affect this.

  Recruiting Karolinska Institutet · Stockholm, Solna · NCT06874231

• Observational study on schizophrenia and psychotic disorders

  This study is trying to understand the causes of schizophrenia and other psychotic disorders by looking at people having their first episode of psychosis and comparing them to healthy individuals over several years.

  Recruiting Karolinska Institutet · Stockholm · NCT06872463

• Omitting full axillary dissection when breast cancer has spread to armpit nodes

  The trial tests whether removing only the sentinel and known cancerous lymph nodes is as safe as removing many more armpit nodes in people with breast cancer and armpit node involvement.

  Recruiting at 4 sites Karolinska Institutet · Helsinki and 3 other locations · NCT06869629

• Multicenter study on acute type A aortic dissection

  This study is trying to learn more about patients with acute type A aortic dissection by looking at their health details, surgeries, and recovery to see what affects their outcomes.

  Recruiting Karolinska Institutet · Stockholm · NCT06862583

• HealthyMoms4MentalHealth app to support mental wellbeing in pregnancy

  This project will test whether the HealthyMoms4MentalHealth app can help pregnant women feel mentally better during pregnancy and the first weeks after birth.

  Recruiting at 4 sites Karolinska Institutet · Jönköping and 3 other locations · NCT06862193

• Digital lifestyle intervention to prevent cardiovascular disease

  This study tests if a digital program can help people aged 40-60 in Sweden make healthier lifestyle choices to prevent heart disease.

  Recruiting at 5 sites Karolinska Institutet · Gävle and 5 other locations · NCT06847633

• Rehabilitation comparison after thumb flexor tendon repair

  This tests whether starting early active motion or keeping the thumb in a plaster cast for four weeks works better after surgery for a torn thumb flexor tendon in people older than 15.

  Recruiting at 5 sites Karolinska Institutet · Linköping and 4 other locations · NCT06836349

• Evira: digital support added to obesity medication for teens

  This study will try adding the Evira digital tool to obesity medication for 12–17-year-olds to see if it improves weight outcomes and sticking with treatment compared with medication alone.

  Recruiting at 3 sites Karolinska Institutet · Linköping and 2 other locations · NCT06836284

• Web-based rehab after wrist salvage surgery

  A web-based rehabilitation program is tested to see if it works as well as standard in-person rehab after wrist salvage surgery for osteoarthritis.

  Recruiting Karolinska Institutet · Stockholm · NCT06814821

• Online cognitive behavior therapy for patients with mild mental health issues

  This study tests if online cognitive behavior therapy can help adults with mild mental health issues feel better and improve their quality of life compared to regular care.

  Recruiting Karolinska Institutet · Gustavsberg, Stockholm County · NCT06804954

• Online cognitive behavior therapy for common mental disorders in primary care

  This study is testing whether online cognitive behavior therapy can help adults with common mental health issues feel better compared to regular care they usually receive.

  Recruiting Karolinska Institutet · Gustavsberg, Stockholm County · NCT06804941

• Digital intervention to promote healthy lifestyle behaviors in infants

  This study tests if the Health4Life app can help parents encourage healthier habits in their infants, like better eating, more activity, and less screen time.

  Recruiting Karolinska Institutet · Huddinge · NCT06798597

• Understanding and treating fatigue in primary care patients

  This study is testing a new online therapy for fatigue to see if it helps people in primary care feel better compared to regular treatment.

  Recruiting Karolinska Institutet · Stockholm, Gustavsberg · NCT06786832

• Arthroscopic lysis and lavage versus operative arthroscopy for TMJ disc displacement with reduction

  This study tests two types of TMJ arthroscopy to see which one better improves mouth opening, reduces pain, and helps daily function in adults with painful disc displacement that reduces.

  Recruiting Karolinska Institutet · Huddinge · NCT06782191

• Arthroscopy versus arthrocentesis for TMJ disc displacement without reduction

  This trial will try two surgical procedures — arthroscopic lysis and lavage versus arthrocentesis — to see which better helps adults with painful TMJ disc displacement that limits mouth opening.

  Recruiting Karolinska Institutet · Huddinge · NCT06782178

• Long-term follow-up after TMJ surgery to see if 6-month results predict outcomes about 10 years later

  This will see if people who had TMJ surgery for disc displacement still have the same results at about 10 years as they did at 6 months, and whether their joint X-rays show more or less degeneration.

  Recruiting Karolinska Institutet · Huddinge · NCT06782165

• Investigating dysfunctional breathing in patients with post COVID-19 condition

  This study is trying to see how breathing problems affect people who are dealing with long-term symptoms after having COVID-19.

  Recruiting Karolinska Institutet · Stockholm, Solna and 1 other locations · NCT06776263

• Innovative strategies to understand and combat severe dengue

  This study is trying to find out what makes dengue infections more severe by looking at blood samples from patients in areas where dengue is common, to help improve treatment and prevention.

  Recruiting at 2 sites Karolinska Institutet · Guatemala City and 1 other locations · NCT06751836

• A program to help older adults improve daily living skills

  This study is testing a new program to see if it can help older adults who receive home care improve their daily living skills and overall quality of life.

  Recruiting Karolinska Institutet · Huddinge, Sweden and 1 other locations · NCT06749080

• Cardiac imaging for patients with Fontan circulation

  This study is testing if special heart scans can help find early heart problems in patients who have had Fontan surgery for univentricular heart conditions, so they can get treatment before things get worse.

  Recruiting Karolinska Institutet · Stockholm · NCT06735521

• Cognitive effects of stomach or esophagus cancer surgery

  This study will see how often people who have surgery for stomach or esophagus cancer develop postoperative delirium and whether it is linked to preoperative depression, frailty, malnutrition, sarcopenia, or lower quality of life.

  Recruiting Karolinska Institutet · Huddinge · NCT06687291

• Telemedicine for contraceptive counseling compared to standard care

  This study is testing a new telemedicine service for contraceptive counseling to see if it helps more people in South Africa and Kenya choose long-acting birth control after an abortion compared to regular in-person counseling.

  Recruiting at 2 sites Karolinska Institutet · Cape Town and 1 other locations · NCT06682065

• Re-examination of participants from the Swedish CArdioPulmonary bioImage Study

  This study is looking at around 15,000 people from a previous heart and lung health study to see how their conditions have changed over the years and to improve ways to predict and prevent heart and lung diseases.

  Recruiting at 6 sites Karolinska Institutet · Gothenburg and 5 other locations · NCT06679777

• Impact of physical activity on surgery outcomes

  This study is trying to see if being more physically active before surgery can help adults avoid complications and live longer after having non-heart-related surgery.

  Recruiting Karolinska Institutet · Stockholm · NCT06678360

• Program to support healthcare managers in promoting employee recovery

  This study tests a program that helps healthcare managers learn how to better support their employees' recovery from burnout and improve their sleep.

  Recruiting at 2 sites Karolinska Institutet · Gothenburg and 1 other locations · NCT06678347

• Epicatechin for muscle fat and weakness in advanced chronic kidney disease

  This study will give 100 mg/day of the nutraceutical epicatechin for 8 weeks to people with advanced CKD to see if it increases muscle mass, reduces fat in muscle, and improves strength.

  Recruiting Karolinska Institutet · Huddinge, Stockholm County · NCT06631820

• Improving prevention and care for pregnant and postpartum adolescent girls and young women with HIV in Tanzania

  This project will test a co-designed package of services to help pregnant and postpartum adolescent girls and young women (15–24) with HIV in Tanzania stay on treatment, keep their babies HIV-free, and remain in care.

  Recruiting at 2 sites Karolinska Institutet · Dar es Salaam and 1 other locations · NCT06605053

• Following individuals with specific autoantibodies to understand disease progression

  This study is tracking people with specific autoantibodies to see how their health changes over time and to learn more about the development of autoimmune diseases.

  Recruiting Karolinska Institutet · Stockholm · NCT06594861

• Investigating the causes and progression of axial spondylitis

  This study is trying to understand how axial spondylitis starts and progresses in newly diagnosed patients to help improve treatments and find better ways to prevent the disease.

  Recruiting at 2 sites Karolinska Institutet · Huddinge, Stockholm County and 1 other locations · NCT06594107

• Individualised model-informed dosing for pulmonary tuberculosis

  This project will test whether using model-informed precision dosing (MIPD) early in treatment helps clinicians get TB drug levels into the right range for adults with pulmonary tuberculosis.

  Recruiting at 2 sites Karolinska Institutet · Linköping and 1 other locations · NCT06585358

• Internet therapy for OCD in children with autism

  This study is testing an online therapy program to see if it can help children with autism and OCD feel better by reducing their symptoms.

  Recruiting at 3 sites Karolinska Institutet · Lund, Skåne County and 2 other locations · NCT06582225

• Investigating mortality and cardiovascular diseases in adults with type 1 diabetes

  This study looks at how type 1 diabetes affects the risk of dying and heart problems in adults compared to those with type 2 diabetes and people without diabetes.

  Recruiting Karolinska Institutet · Stockholm · NCT06563401

• Apixaban versus warfarin for left ventricular clot after a heart attack

  This compares apixaban and warfarin to see which better clears left-ventricular blood clots in adults after a heart attack.

  Recruiting at 3 sites Phase 4 Karolinska Institutet · Falun and 15 other locations · NCT06515730

• Understanding cognitive recovery in older adults after heart surgery

  This study looks at how heart surgery affects the thinking and memory skills of older adults aged 65 and up, and it also gathers insights from their family members about these changes.

  Recruiting Karolinska Institutet · Gothenburg · NCT06469515

• Examining the effects of bariatric surgery on heart disease and mortality

  This study is trying to see if different types of weight-loss surgery can help people with obesity lower their risk of heart disease and live longer compared to those who don't have surgery.

  Recruiting Karolinska Institutet · Stockholm · NCT06420479

• Investigating fatigue and cognitive dysfunction in patients after stem cell transplantation

  This study is trying to see if there are specific signs in the blood and spinal fluid that can help identify fatigue and thinking problems in patients who have had stem cell transplants.

  Recruiting Karolinska Institutet · Stockholm · NCT06363396

• Impact of Advanced Trauma Life Support on outcomes for trauma patients

  This study tests if training doctors in Advanced Trauma Life Support can help adult trauma patients in India recover better and have improved outcomes compared to standard care.

  Recruiting at 10 sites Karolinska Institutet · Dibrugarh, Assam and 9 other locations · NCT06321419

• Balance training program for people with Multiple Sclerosis

  This study tests a new balance training program for people with Multiple Sclerosis to see if it helps them walk better and feel more independent.

  Recruiting Karolinska Institutet · Stockholm, Stockholm County · NCT06312046

• Online therapy for anxiety after heart issues

  This study is testing an online therapy program to see if it can help people recovering from heart issues feel less anxious and improve their quality of life.

  Recruiting Karolinska Institutet · Stockholm · NCT06298864

• Internet-based behavior therapy for adults with Tourette syndrome

  This study is testing whether an online behavior therapy can help adults with Tourette syndrome reduce their tics and improve their overall well-being compared to general support.

  Recruiting Karolinska Institutet · Stockholm · NCT06271083

• Online therapy for children and teens with body dysmorphic disorder

  This study is testing if an online therapy program can help children and teens with body dysmorphic disorder feel better compared to those who receive a relaxation treatment.

  Recruiting at 3 sites Karolinska Institutet · Gothenburg and 2 other locations · NCT06262412

• Investigating gene and microbiome profiles in gum diseases

  This study is trying to see how genes and bacteria in the mouth are related to gum diseases like periodontitis and peri-implantitis in adults to help improve diagnosis and treatment.

  Recruiting Karolinska Institutet · Stockholm · NCT06262035

• Impact of mitral valve surgery on ventricular arrhythmias

  This study is testing how mitral valve surgery helps people with mitral valve prolapse and arrhythmias by looking at their heart health before and after the operation.

  Recruiting Karolinska Institutet · Stockholm, Stockholm County · NCT06255457

• Analyzing immune system issues in patients

  This study is trying to collect blood and stool samples from people with immune system problems and healthy individuals to better understand these issues and help improve treatments.

  Recruiting Karolinska Institutet · Stockholm · NCT06248957

• Comparing two therapies for children's anxiety in primary care

  This study is testing a new therapy called 'Step-by-Step' for children with anxiety to see if it works as well as the existing 'Cool Kids' program.

  Recruiting Karolinska Institutet · Solna · NCT06212362

• Therapist-guided online treatment for PTSD in Swedish immigrants

  This study is testing an online therapy program for Swedish immigrants with PTSD to see if it helps reduce their symptoms and improve their quality of life.

  Recruiting Karolinska Institutet · Solna · NCT06193161

• Internet-delivered therapy for young people with PTSD

  This study is testing if a special online therapy for PTSD can help young people aged 13-17 feel better compared to a different online therapy that focuses on relaxation and education.

  Recruiting Karolinska Institutet · Stockholm · NCT06185244

• High-intensity interval training for patients with lupus

  This study is testing whether a special exercise program that includes high-intensity workouts can help people with lupus improve their fitness, muscle strength, and overall well-being.

  Recruiting Karolinska Institutet · Stockholm, Huddinge · NCT06166199

• Understanding immune cells in diabetic foot ulcers

  This study looks at how immune cells behave in people with diabetes who have foot ulcers to see if understanding them can help improve healing for those with chronic wounds.

  Recruiting Karolinska Institutet · Huddinge, Stockholm County · NCT06154915

• Comparing wrist denervation and exercise for wrist osteoarthritis

  This study is testing whether surgery to numb certain nerves in the wrist works better than a guided exercise program for people with wrist osteoarthritis.

  Recruiting at 2 sites Karolinska Institutet · Malmö and 1 other locations · NCT06098586

• Online emotion-regulation treatment for youth mental health

  This study is testing an online program to help teenagers aged 12-17 manage their emotions better and see if it can improve their mental health.

  Recruiting Karolinska Institutet · Stockholm · NCT06067165

• Intralymphatic immunotherapy with Vitamin D for grass pollen allergies

  This study is testing if a new treatment using Vitamin D with intralymphatic immunotherapy can help people with grass pollen allergies feel better during allergy season.

  Recruiting Phase 2/3 Karolinska Institutet · Lund and 2 other locations · NCT06061848

• Online psychological program for cancer survivors

  This trial tests whether different parts of a 10-week therapist-guided online psychological program help adult cancer survivors with anxiety, depression, or fear of recurrence.

  Recruiting Karolinska Institutet · Stockholm · NCT06046586

• Effect of early nasal cooling on survival after cardiac arrest

  This study is testing if cooling patients right after a cardiac arrest can help them survive better and recover their brain function compared to standard care.

  Recruiting at 15 sites Karolinska Institutet · Graz and 16 other locations · NCT06025123

• Evaluating the impact of walking on surgical outcomes

  This study is trying to see if the number of steps people take before non-heart surgery can affect how well they recover afterwards.

  Recruiting Karolinska Institutet · Stockholm · NCT06023069

• Comparing surgical and non-surgical treatments for finger osteoarthritis

  This study is testing whether surgery or non-surgical treatments like education and exercise work better for people with osteoarthritis in their finger joints.

  Recruiting Karolinska Institutet · Stockholm · NCT05980793

• Comparing intensive and standard treatment for PTSD in adults

  This study is testing if a new, more intense 5-day therapy for PTSD can help adults recover faster and better than the usual weekly sessions over 15 weeks.

  Recruiting Karolinska Institutet · Stockholm · NCT05934175

• Home monitoring and molecular profiling of patients with long COVID focusing on lung issues

  This study is testing a mobile app to help people with long COVID and lung problems track their symptoms and understand the biological reasons behind their condition.

  Recruiting Karolinska Institutet · Stockholm, Sverige · NCT05894616

• Understanding the genetic causes of skeletal diseases

  This study is trying to find the genetic causes of congenital skeletal disorders to help improve diagnosis and treatment for people affected by these conditions.

  Recruiting Karolinska Institutet · Stockholm · NCT05876416

• Reconstructing schoolyards to boost children's physical activity and address climate change

  This study is testing if making schoolyards greener can help kids in Stockholm be more active and improve their health over three years.

  Recruiting Karolinska Institutet · Stockholm · NCT05865782

• Program to prevent eating disorders by enhancing protective factors

  This study is testing a new program aimed at helping young people aged 15-20 who struggle with body image issues to see if it can prevent eating disorders by promoting a healthier relationship with their bodies.

  Recruiting Karolinska Institutet · Solna · NCT05863598

• A support system for psychiatric diagnostics and follow-up

  This study is testing new self-assessment tools to help adults share information about their psychiatric symptoms so doctors can make better diagnoses and follow-ups.

  Recruiting at 5 sites Karolinska Institutet · Stockholm and 4 other locations · NCT05827406

• Preventing and rehabilitating stroke in Uganda

  This study is trying to find out what causes strokes in Uganda and how to prevent and help people recover from them.

  Recruiting at 2 sites Karolinska Institutet · Hoima and 1 other locations · NCT05807269

• Blended treatment for PTSD using computer-assisted therapy

  This study is testing a new blended therapy for PTSD that combines online and in-person sessions to see if it works as well as the usual face-to-face treatment.

  Recruiting Karolinska Institutet · Stockholm · NCT05758987

• Investigating the effects of botulinum toxin on jaw pain mechanisms

  This study is testing if botulinum toxin can help reduce jaw pain by looking at how it affects the muscles and nerves in people with and without jaw disorders.

  Recruiting Phase 2 Karolinska Institutet · Huddinge, Stockholm County · NCT05720065

• Improving oral health in patients with severe eating disorders

  This study is testing if dental treatment can improve the quality of life for people with severe eating disorders like anorexia or bulimia.

  Recruiting Karolinska Institutet · Stockholm · NCT05703789

• Examining how the menstrual cycle affects exercise performance

  This study tests how different phases of the menstrual cycle affect exercise performance in women who train hard to see if adjusting workouts can improve their fitness and reduce symptoms.

  Recruiting Karolinska Institutet · Stockholm · NCT05697263

• Comparing surgical and non-surgical treatments for finger nerve injuries

  This study is testing whether surgery or a cast works better for helping adults with finger nerve injuries recover and regain feeling and movement.

  Recruiting Karolinska Institutet · Stockholm, Stockholm County · NCT05536609

• Internet-based therapy for pregnant women with depression

  This study tests if adding extra support from a midwife or mental health nurse makes internet-based therapy more effective for pregnant women dealing with depression.

  Recruiting Karolinska Institutet · Stockholm · NCT05533138

• Examining ICU Admission Patterns Based on Gender and Ethnicity

  This study looks at whether doctors admit patients to the ICU differently based on their gender and ethnicity, even when they are seriously ill.

  Recruiting Karolinska Institutet · Stockholm · NCT05513456

• Investigating how different diabetes medications affect fat tissue in type 2 diabetes patients

  This study is testing how three different diabetes medications affect fat tissue in people with newly diagnosed type 2 diabetes who aren't meeting their blood sugar goals on metformin.

  Recruiting Karolinska Institutet · Stockholm · NCT05501483

• A digital platform to help manage gestational diabetes

  This study is testing whether a mobile health platform called SPARK can help women with gestational diabetes manage their condition better by providing support for healthy eating and exercise.

  Recruiting Karolinska Institutet · Linköping · NCT05348863

• HPV screening for women aged 23-29

  This study tests if using HPV screening can better protect women aged 23-29 from cervical cancer compared to the usual method of checking cells.

  Recruiting Karolinska Institutet · Lund, Skåne County and 1 other locations · NCT05229679

Showing recruiting studies first, then the newest. Describe your situation to find the ones that fit you.

Quick answers

How many clinical trials run by Karolinska Institutet are recruiting right now?

179, as of November 12, 2026. 6 of them were first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 22 countries. The most sites are in Sweden (172 trials), Italy (3 trials), Norway (3 trials), Finland (3 trials), India (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2/3: 3, Phase 2: 3, Phase 3: 2, Phase 4: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

Describe your situation →