Clinical trial Recruiting at 10 sites Interventional Ages 15 and up

Impact of Advanced Trauma Life Support on outcomes for trauma patients

Official title: Effects of Advanced Trauma Life Support® Training Compared to Standard Care on Adult Trauma Patient Outcomes: A Cluster Randomised Trial

Run by Karolinska Institutet · NCT06321419 · Data updated 2026-11-12

This study tests if training doctors in Advanced Trauma Life Support can help adult trauma patients in India recover better and have improved outcomes compared to standard care.

More Wounds and Injuries trials

Quick facts

Study typeInterventional
Ages15 Years and up
SexAll
Enrollment4320 (estimated)
SponsorKarolinska Institutet
Academic / other
Locations10 sites (Dibrugarh, Assam and 9 other locations)
StatusRecruiting
StartedFebruary 27, 2025
Main results expectedNovember 2029
Study endsNovember 2029
Registry record updatedJanuary 23, 2026
Trial IDNCT06321419 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are adult trauma patients aged 15 years and older who present to the emergency department within 48 hours of their injury.

Probably not a fit

Patients with isolated limb injuries or those directly admitted to a ward without emergency department evaluation may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to evaluate the effectiveness of Advanced Trauma Life Support (ATLS) training compared to standard care in improving outcomes for adult trauma patients. It will involve adult patients presenting to emergency departments of participating hospitals in India, where physicians trained in ATLS will manage their care. The study will assess various outcomes, including mortality, disability, return to work, and quality of life, to determine if ATLS training leads to better patient results.

Why it matters

Potential benefit: If successful, this study could lead to improved survival rates and quality of life for trauma patients through enhanced training for healthcare providers.

How similar studies have gone: While ATLS is widely used, this study is novel as it seeks to provide controlled evidence of its effectiveness in improving patient outcomes.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* age of at least 15 years;
* trauma occurred less than 48 hours before arrival at the hospital;
* present to the emergency department of participating hospitals, with a history of trauma defined as having any of the reasons listed in the International Classification of Diseases chapter XX as the reason for presenting;
* admitted or died between arrival at the hospital and admission, or referred/transferred from the emergency department of a participating hospital to another hospital for admission; and
* managed by a participating cluster in the emergency department.

Exclusion Criteria:

* present with isolated limb injuries; or
* are directly admitted to a ward without being seen by a physician in the emergency department.

Where it's running

  • Assam Medical College & Hospital
    Dibrugarh, Assam, India
    Recruiting
  • KEM Hospital
    Mumbai, Maharashtra, India
    Recruiting
  • Lokmanya Tilak Municipal General Hospital
    Mumbai, Maharashtra, India
    Recruiting
  • Hridaysamrat Balasaheb Thackre Mun. Medical college and Dr. R.N. Cooper Hospital
    Mumbai, Maharashtra, India
    Recruiting
  • Holy Family Hospital
    New Delhi, New Delhi, India
    Recruiting
  • Dayanand Medical College & Hospital
    Ludhiana, Punjab, India
    Recruiting
Show 4 more locations
  • Christian Medical College & Hospital
    Ludhiana, Punjab, India
    Recruiting
  • Himalayan Institute of Medical Sciences, Swami Rama Himalayan University
    Dehradun, Uttarakhand, India
    Recruiting
  • Institute of Post-Graduate Medical Education and Research and Seth Sukhlal Karnani Memorial Hospital (IPGMER and SSKM Hospital)
    Kolkata, West Bengal, India
    Recruiting
  • Government Medical College Hospital
    Chandigarh, India
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.