Impact of Advanced Trauma Life Support on outcomes for trauma patients
Official title: Effects of Advanced Trauma Life Support® Training Compared to Standard Care on Adult Trauma Patient Outcomes: A Cluster Randomised Trial
Run by Karolinska Institutet · NCT06321419 · Data updated 2026-11-12
This study tests if training doctors in Advanced Trauma Life Support can help adult trauma patients in India recover better and have improved outcomes compared to standard care.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 15 Years and up |
| Sex | All |
| Enrollment | 4320 (estimated) |
| Sponsor | Karolinska Institutet Academic / other |
| Locations | 10 sites (Dibrugarh, Assam and 9 other locations) |
| Status | Recruiting |
| Started | February 27, 2025 |
| Main results expected | November 2029 |
| Study ends | November 2029 |
| Registry record updated | January 23, 2026 |
| Trial ID | NCT06321419 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adult trauma patients aged 15 years and older who present to the emergency department within 48 hours of their injury.
✕Probably not a fit
Patients with isolated limb injuries or those directly admitted to a ward without emergency department evaluation may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to evaluate the effectiveness of Advanced Trauma Life Support (ATLS) training compared to standard care in improving outcomes for adult trauma patients. It will involve adult patients presenting to emergency departments of participating hospitals in India, where physicians trained in ATLS will manage their care. The study will assess various outcomes, including mortality, disability, return to work, and quality of life, to determine if ATLS training leads to better patient results.
Why it matters
Potential benefit: If successful, this study could lead to improved survival rates and quality of life for trauma patients through enhanced training for healthcare providers.
How similar studies have gone: While ATLS is widely used, this study is novel as it seeks to provide controlled evidence of its effectiveness in improving patient outcomes.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * age of at least 15 years; * trauma occurred less than 48 hours before arrival at the hospital; * present to the emergency department of participating hospitals, with a history of trauma defined as having any of the reasons listed in the International Classification of Diseases chapter XX as the reason for presenting; * admitted or died between arrival at the hospital and admission, or referred/transferred from the emergency department of a participating hospital to another hospital for admission; and * managed by a participating cluster in the emergency department. Exclusion Criteria: * present with isolated limb injuries; or * are directly admitted to a ward without being seen by a physician in the emergency department.
Where it's running
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Assam Medical College & Hospital
Dibrugarh, Assam, India Recruiting -
KEM Hospital
Mumbai, Maharashtra, India Recruiting -
Lokmanya Tilak Municipal General Hospital
Mumbai, Maharashtra, India Recruiting -
Hridaysamrat Balasaheb Thackre Mun. Medical college and Dr. R.N. Cooper Hospital
Mumbai, Maharashtra, India Recruiting -
Holy Family Hospital
New Delhi, New Delhi, India Recruiting -
Dayanand Medical College & Hospital
Ludhiana, Punjab, India Recruiting
Show 4 more locations
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Christian Medical College & Hospital
Ludhiana, Punjab, India Recruiting -
Himalayan Institute of Medical Sciences, Swami Rama Himalayan University
Dehradun, Uttarakhand, India Recruiting -
Institute of Post-Graduate Medical Education and Research and Seth Sukhlal Karnani Memorial Hospital (IPGMER and SSKM Hospital)
Kolkata, West Bengal, India Recruiting -
Government Medical College Hospital
Chandigarh, India Recruiting
Study contacts
- Study coordinator: Martin Gerdin Wärnberg, PhD
- Email: martin.gerdin@ki.se
- Phone: +46708539598
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.