Dementia with Lewy Bodies: Symptoms, Biomarkers and Progression
Official title: Dementia With Lewy Bodies: Clinical Symptoms, Biomarkers and Progression
Run by Karolinska Institutet · NCT07629349 · Data updated 2026-11-12
This study tests how well clinical features, biological markers, and brain scans distinguish DLB and its early stages in patients seen at Stockholm clinics.
Quick facts
| Study type | Observational |
|---|---|
| Sex | All |
| Enrollment | 600 (estimated) |
| Sponsor | Karolinska Institutet Academic / other |
| Locations | 1 site (Stockholm) |
| Status | Recruiting |
| Started | January 1, 2020 |
| Main results expected | March 1, 2031 |
| Study ends | March 1, 2031 |
| Registry record updated | June 5, 2026 |
| Trial ID | NCT07629349 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates have at least one core feature of DLB (visual hallucinations, parkinsonism, cognitive fluctuations, or probable REM sleep behavior disorder).
✕Probably not a fit
Patients with cognitive impairment due to causes unrelated to DLB or MCI, or those using certain medications, may see limited benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study collects clinical data, imaging, and fluid biomarkers from patients with DLB, MCI, cognitively unimpaired individuals, and other dementias. It combines retrospective data up to 2020 with prospective data from 2020 onward to improve power and replication. The Find-DLB cohort is drawn from Stockholm cognitive clinics and linked with national and international datasets to broaden representativeness. The aim is to better detect DLB and its prodromal phases and to deepen understanding of underlying biology and potential therapies.
Why it matters
Potential benefit: If successful, the study could improve early detection and understanding of DLB, potentially guiding earlier management and research directions.
How similar studies have gone: Previous observational work in DLB and related disorders has shown that combining clinical data with biomarkers can improve characterization and prediction.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * At least one core clinical feature of dementia with Lewy bodies such as visual hallucinations, parkinsonism, cognitive fluctuations, or probable REM sleep behaviour disorder. Exclusion Criteria: * Causes of cognitive impairment other than those related to dementia or MCI. Current or pass drug use.
Where it's running
-
Karolinska University Hospital
Stockholm, Sweden Recruiting
Study contacts
- Study coordinator: Daniel Ferreira, Docent, Senior Lecturer
- Email: daniel.ferreira.padilla@ki.se
- Phone: +46720128047
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.