Clinical trial Recruiting at 1 site Observational

Dementia with Lewy Bodies: Symptoms, Biomarkers and Progression

Official title: Dementia With Lewy Bodies: Clinical Symptoms, Biomarkers and Progression

Run by Karolinska Institutet · NCT07629349 · Data updated 2026-11-12

This study tests how well clinical features, biological markers, and brain scans distinguish DLB and its early stages in patients seen at Stockholm clinics.

Quick facts

Study typeObservational
SexAll
Enrollment600 (estimated)
SponsorKarolinska Institutet
Academic / other
Locations1 site (Stockholm)
StatusRecruiting
StartedJanuary 1, 2020
Main results expectedMarch 1, 2031
Study endsMarch 1, 2031
Registry record updatedJune 5, 2026
Trial IDNCT07629349 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates have at least one core feature of DLB (visual hallucinations, parkinsonism, cognitive fluctuations, or probable REM sleep behavior disorder).

Probably not a fit

Patients with cognitive impairment due to causes unrelated to DLB or MCI, or those using certain medications, may see limited benefit.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study collects clinical data, imaging, and fluid biomarkers from patients with DLB, MCI, cognitively unimpaired individuals, and other dementias. It combines retrospective data up to 2020 with prospective data from 2020 onward to improve power and replication. The Find-DLB cohort is drawn from Stockholm cognitive clinics and linked with national and international datasets to broaden representativeness. The aim is to better detect DLB and its prodromal phases and to deepen understanding of underlying biology and potential therapies.

Why it matters

Potential benefit: If successful, the study could improve early detection and understanding of DLB, potentially guiding earlier management and research directions.

How similar studies have gone: Previous observational work in DLB and related disorders has shown that combining clinical data with biomarkers can improve characterization and prediction.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* At least one core clinical feature of dementia with Lewy bodies such as visual hallucinations, parkinsonism, cognitive fluctuations, or probable REM sleep behaviour disorder.

Exclusion Criteria:

* Causes of cognitive impairment other than those related to dementia or MCI. Current or pass drug use.

Where it's running

  • Karolinska University Hospital
    Stockholm, Sweden
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

  • Exploring the effects of sleep and exercise on Alzheimer's risk

    This study is testing how good sleep and regular exercise might lower the risk of developing Alzheimer's disease over time.

    Recruiting University of Miami · Miami, Florida · NCT04855630

  • Comprehensive assessment of neurodegeneration and dementia

    This project will collect brain scans, cognitive tests, and biological samples over time to see how dementia and related conditions progress in adults aged 50–90, including people with Parkinson's and people without cognitive problems.

    Recruiting at 11 sites McGill University · Calgary, Alberta and 18 other locations · NCT03402919

  • Rural Veterans and Care Partners Walking Program

    A virtual walking program is tested to see if it can help Veterans with mild cognitive impairment and their care partners in rural areas walk more each day.

    Recruiting Creighton University · Omaha, Nebraska · NCT07914218

  • China HEAD: a large community study on healthy aging and dementia

    This study tests whether collecting health, imaging, and biospecimen data from adults in China can help predict who will develop Alzheimer’s disease and related dementias.

    Recruiting at 30 sites Fudan University · Beijing and 29 other locations · NCT07912710

  • Aging Brain Health Initiative in Fujian

    This observational study will follow about 3,000 older adults in Fujian to see how Alzheimer's-related changes develop and to test new digital tests, biomarkers, and imaging tools for early diagnosis.

    Recruiting at 4 sites Fujian Medical University Union Hospital · Fushun, Fujian and 3 other locations · NCT07891429

  • See if multimodal biomarkers can map changes from mild cognitive impairment to dementia

    This observational study tests whether clinical, blood, and brain-imaging markers can tell apart stages of cognitive decline and predict progression from mild cognitive impairment to dementia in about 600 people.

    Recruiting Xuanwu Hospital, Beijing · Beijing, Beijing Municipality · NCT07876570

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.