Preserving muscle during weight loss with incretin therapy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Women with obesity (BMI ≥35) who are about to begin incretin-based pharmacotherapy will perform supervised unilateral resistance training while receiving treatment. The trial will assess changes in skeletal muscle volume, strength, fatigue, body composition, and cardiac structure and function, alongside molecular profiles in muscle, fat, and blood. It uses a targeted design to see if training protects muscle during drug-induced weight loss and improves overall metabolic health. Outcomes may inform how to combine exercise with incretin therapies in routine care. Imaging and biopsies are used to capture detailed tissue and molecular responses.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Women aged 18-64 years with obesity, BMI ≥35 kg/m²
* Planned initiation of incretin-based obesity pharmacotherapy as part of routine clinical care.
* Able to participate in supervised unilateral resistance training.
* Able to complete physical function tests.
* Able to attend study visits at the study center.
* Able to provide written informed consent in the Swedish language.

Exclusion Criteria:

* Contraindication to magnetic resonance imaging.
* Medical condition preventing resistance training or physical-function testing.
* Medical condition preventing skeletal muscle or adipose-tissue biopsy.
* A weight reduction \>5% during the last 3 months.
* Patients diagnosed with any known serious chronic illness, including type 1 or 2 diabetes (or a randomly measured fasting plasma glucose \>7 mmol/L).
* Angina pectoris, coronary heart disease or congestive heart failure (NYHA Class III- IV).
* Severe renal impairment (creatinine clearance (GFR) \<30 mL/min).
* Severe hepatic impairment.
* Inflammatory bowel disease.
* Gastroparesis.
* Cancer.
* Chronic obstructive lung disease.
* Severe psychiatric disorders.
* Previous bariatric surgery.
* A history of idiopathic acute pancreatitis.
* The use of medications that cause clinically significant weight gain or loss.
* A family or personal history of multiple endocrine neoplasia type 2 or familial medullary thyroid carcinoma.
* Osteoarthritis, which is judged to be too severe to manage the exercise programme.
* Pregnancy, expecting pregnancy or breast feeding.
* Hypersensitivity to the planned incretin-based medication or any of its excipients.
* Regular exercise training at high intensity (eg, spinning) \>2 hours per week.
* Inability to understand the study information in Swedish or provide informed consent.

Where it's running

• Karolinska University Hospital Huddinge
  Stockholm, Stockholm County, Sweden Recruiting

Study contacts

• Study coordinator: Eric B Emanuelsson, PhD
• Email: eric.emanuelsson@ki.se
• Phone: +46730266626

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Robot-assisted sleeve gastrectomy with Hugo system feasibility

  This study tests whether sleeve gastrectomy can be safely done using the Hugo robotic system in adults with severe obesity.

  Recruiting Universitätsklinikum Hamburg-Eppendorf · Hamburg, Free and Hanseatic City of Hamburg · NCT07884994

• Digital follow-up and nursing education after bariatric surgery

  This trial tests whether adding a digital follow-up system plus structured nursing education helps people who have had bariatric surgery improve quality of life, BMI, and activity levels.

  Recruiting Okan University · Istanbul, ÜSKÜDAR · NCT07457034

• Cognitive Rehabilitation of Everyday Goals With GMT: How Different Ways of Delivery Work

  This study tests Goal Management Training to see if a Swedish version helps adults with acquired brain injury or chronic pain improve practical goal-directed thinking and daily functioning.

  Recruiting at 2 sites Karolinska Institutet · Luleå, Norrbotten County and 2 other locations · NCT07924774

• Sensory nerve tests after finger nerve injury

  This study tests whether neurophysiological measurements can reflect finger sensation changes after digital nerve injury, using patients as their own controls.

  Recruiting Karolinska Institutet · Stockholm and 1 other locations · NCT07904286

• National Highly Specialized Care for Severe Self-Harm and Eating Disorders in Swedish Youth

  This observational study tests how well NHV, a highly specialized care program, works for children and teens with severe self-harm or eating disorders by asking patients and their parents about their experiences and what changes they notice.

  Recruiting at 2 sites Karolinska Institutet · Stockholm and 1 other locations · NCT07898059

• Specialist Supportive Clinical Management for teens with anorexia or atypical anorexia

  This study tests a teen-focused SSCM approach to help 13-17 year-olds with anorexia nervosa or atypical anorexia nervosa when other treatments haven’t worked or can’t be used.

  Recruiting Karolinska Institutet · Stockholm · NCT07893145

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.