Understanding immune cells in diabetic foot ulcers
Characterise the Immunological Response of Diabetic Patients With Chronic Foot Ulcers
This study looks at how immune cells behave in people with diabetes who have foot ulcers to see if understanding them can help improve healing for those with chronic wounds.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 40 (estimated) |
| Ages | 18 Years to 98 Years |
| Sex | All |
| Sponsor | Karolinska Institutet Academic / other |
| Locations | 1 site (Huddinge, Stockholm County) |
| Trial ID | NCT06154915 on ClinicalTrials.gov |
What this trial studies
This observational study aims to investigate the role of immune cells in patients with diabetes who have chronic foot ulcers. Researchers will compare blood and tissue samples from diabetic patients with healing or healed ulcers to those with non-healing, chronic ulcers. The study focuses on characterizing the immunological response and identifying potential therapeutic targets for chronic wound treatment. By utilizing advanced methodologies such as transcriptomic and proteomic analysis at the single-cell level, the study seeks to uncover the mechanisms behind impaired healing in diabetic foot ulcers.
Who should consider this trial
Good fit: Ideal candidates for this study are patients with diabetes who have a diabetic foot ulcer.
Not a fit: Patients with impaired cognitive function, ongoing immune suppressive treatment, active cancer, or chronic inflammatory diseases may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to new therapeutic strategies for improving healing in diabetic foot ulcers.
How similar studies have performed: Other studies have shown promise in understanding immune responses in wound healing, but this specific approach is novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * diabetes with diabetic foot ulcer Exclusion Criteria: * impaired cognitive function * on-going immune suppressive treatment * diagnosed active cancer * cancer treatment * known chronic inflammatory disease
Where this trial is running
Huddinge, Stockholm County
- Karolinska University Hospital — Huddinge, Stockholm County, Sweden (Recruiting)
Study contacts
- Principal investigator: cecilia Morgantini, MD — Karolinska Institutet
- Study coordinator: Eva Steninger
- Email: eva.steninger@regionstockholm.se
- Phone: 70 00213 45
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.