Understanding immune cells in diabetic foot ulcers

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to investigate the role of immune cells in patients with diabetes who have chronic foot ulcers. Researchers will compare blood and tissue samples from diabetic patients with healing or healed ulcers to those with non-healing, chronic ulcers. The study focuses on characterizing the immunological response and identifying potential therapeutic targets for chronic wound treatment. By utilizing advanced methodologies such as transcriptomic and proteomic analysis at the single-cell level, the study seeks to uncover the mechanisms behind impaired healing in diabetic foot ulcers.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* diabetes with diabetic foot ulcer

Exclusion Criteria:

* impaired cognitive function
* on-going immune suppressive treatment
* diagnosed active cancer
* cancer treatment
* known chronic inflammatory disease

Where it's running

• Karolinska University Hospital
  Huddinge, Stockholm County, Sweden Recruiting

Study contacts

• Principal investigator: cecilia Morgantini, MD — Karolinska Institutet
• Study coordinator: Eva Steninger
• Email: eva.steninger@regionstockholm.se
• Phone: 70 00213 45

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Miro3D Wound Matrix for Diabetic Foot Ulcers

  This study tests whether adding Miro3D Wound Matrix to standard care helps healing diabetic foot ulcers in adults.

  Recruiting at 6 sites Reprise Biomedical, Inc. · Phoenix, Arizona and 13 other locations · NCT07632001

• Topical Capsadyn (palmitated capsaicin) for diabetic neuropathic foot pain

  This study will test whether a topical Capsadyn cream can reduce foot pain in adults with diabetic peripheral neuropathy.

  Recruiting Early Phase 1 Carilion Clinic · Roanoke, Virginia · NCT07260656

• Single-layer placental graft plus standard care for stubborn diabetic foot ulcers

  This trial will try a single-layer placental-based graft together with usual wound care for adults whose diabetic foot ulcers did not heal after standard treatment in an earlier trial.

  Recruiting Phase 4 Applied Biologics, LLC · Hollywood, Florida · NCT07159282

• Using human placental membrane wraps with regular wound care to help heal stubborn diabetic foot and venous leg ulcers

  This trial tests whether adding one of four human placental membrane wraps to standard wound care helps people with nonhealing diabetic foot or venous leg ulcers heal faster and more completely than standard care alone.

  Recruiting Phase 4 BioLab Holdings · Philidelphia, Pennsylvania · NCT07089602

• Evaluating full-body imaging technology for skin disease detection

  This study is testing a new full-body imaging technology to see if it can help doctors better detect and monitor skin diseases like skin cancer and eczema.

  Recruiting at 3 sites HJN Sverige AB/Neko Health · Stockholm and 2 other locations · NCT06989216

• Non-invasive imaging to measure skin composition and structure

  This study is testing a new non-invasive imaging technology to see if it can accurately measure different components and structures of skin in people visiting their primary care doctor, especially those at higher risk for heart issues or diabetes.

  Recruiting at 3 sites HJN Sverige AB/Neko Health · Stockholm and 2 other locations · NCT06976073

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.