Same-day discharge after robotic-assisted hysterectomy
Official title: DARSH - A Multicenter Randomized Controlled Trial: Day-care vs Overnight Stay in Robotic Assisted Hysterectomy in Patients With Bening Disease and Endometrial Cancer.
Run by Karolinska Institutet · NCT07233811 · Data updated 2026-11-12
This will see if people having robotic-assisted hysterectomy for benign conditions or endometrial cancer can safely go home the same day instead of staying overnight.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 75 Years |
| Sex | Women only |
| Enrollment | 300 (estimated) |
| Sponsor | Karolinska Institutet Academic / other |
| Locations | 3 sites (Stockholm and 2 other locations) |
| Status | Recruiting |
| Started | January 1, 2025 |
| Main results expected | June 2027 |
| Study ends | January 2028 |
| Registry record updated | November 18, 2025 |
| Trial ID | NCT07233811 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
People 75 years old or younger scheduled for total robotic hysterectomy (benign or endometrial cancer), who have someone at home the first night, do not require concurrent complex procedures, and have no major uncontrolled comorbidities are the ideal candidates.
✕Probably not a fit
Patients over 75, those without someone at home the first night, patients needing simultaneous prolapse or lymph node surgery, those with severe endometriosis or chronic pain regimens, or with significant non-BMI-related ASA class 3 comorbidity are unlikely to benefit from same-day discharge.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a multicenter randomized non-inferiority trial across three Stockholm hospitals comparing same-day discharge to overnight admission after robotic-assisted total hysterectomy. Patients with benign indications and those with endometrial cancer are randomized 1:1 with stratification by malignancy, and care pathways are standardized across sites. Quality of life is measured before surgery and on days 3, 7 and 30 using the EQ-5D-5L instrument, and surgical complications within 30 days are recorded to compare safety. Additional patient satisfaction at day 30 is captured with a Swedish-validated QPP questionnaire.
Why it matters
Potential benefit: If successful, same-day discharge could reduce hospital stays and speed recovery while keeping complication rates similar.
How similar studies have gone: Previous observational and some randomized studies of minimally invasive hysterectomy, including robotic series, have shown same-day discharge can be feasible and safe in selected patients, but randomized multicenter data that include cancer cases remain limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patient that are planned to undergo total robotic hysterectomy with or without adnexal surgery at the three sites. * Both benign conditions and endometrial cancer. * All BMI groups and all uterus sizes. Exclusion Criteria: * Age not over 75 years old, * No company at home first night after surgery * ASA class 3 that is not only because of high BMI. * Simultaneous prolapse surgery/lymph node evacuation. * Severe endometriosis or patients with chronic pain conditions that have a special pain regimen after surgery.
Where it's running
-
Södersjukhuset
Stockholm, Sweden Recruiting -
Danderyd Hospital
Stockholm, Sweden Recruiting -
Karolinska University hospital
Stockholm, Sweden Recruiting
Study contacts
- Principal investigator: Malin Brunes, MD,PhD — Karolinska Institutet
- Study coordinator: Emily Benér, MD
- Email: emily.bener@ki.se
- Phone: +46705554427
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Predictors of Success and Failure of v-NOTES Hysterectomy for Large Uteri
This study looks at which factors predict whether a v-NOTES hysterectomy for large uteri will be completed without needing to switch to another surgical approach.
-
Hybrid robotic surgery for gynecologic procedures using ROB platform
This study tests whether the ROB robotic platform and its endoscopic instruments can be safely used to perform laparoscopic hysterectomy with or without removal of tubes and/or ovaries in adult women.
-
Biofeedback-Assisted Pelvic Floor Training After Hysterectomy
This study tests whether biofeedback-guided pelvic floor exercises after hysterectomy can improve pelvic floor strength, reduce urinary leakage, lessen genital prolapse, and boost quality of life.
-
Single-port robotic vs traditional laparoscopic surgery for proximal stomach cancer
This trial tests whether a single-port robotic approach can safely and effectively remove proximal stomach cancer compared with conventional laparoscopy.
-
Effectiveness of M-TAPA nerve block for pain relief after laparoscopic hysterectomy
This study tests whether the M-TAPA nerve block before surgery can reduce opioid use and pain after laparoscopic hysterectomy compared with standard pain care.
-
Reading a personal narrative book to help emotional regulation before hysterectomy in young women
This trial tests whether reading a personal narrative book in addition to usual care can help young women preparing for hysterectomy feel calmer and less anxious or depressed.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.