Early double sequential defibrillation for cardiac arrest outside the hospital

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized interventional trial compares double sequential defibrillation (two defibrillators delivering shocks in rapid sequence with anterior‑lateral and anterior‑posterior pad placements) to continued standard single‑defibrillator shocks in adults with out‑of‑hospital cardiac arrest who have an initial shockable rhythm and at least one failed standard shock. Patients are enrolled by participating emergency medical services and assigned to either the DSD strategy or standard care during active resuscitation. The primary focus is survival following early application of DSD, with attention to neurologic outcome and termination of ventricular fibrillation. Children, known DNR patients, and those with obvious pregnancy are excluded.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* OHCA patients with VT/VF at first rhythm analysis and at least one defibrillation performed in standard (A-L) position

Exclusion Criteria:

* Age \< 18 years
* Obvious pregnancy
* Known preexisting Do Not Attempt Resuscitation order

Where it's running

• Ambulanssjukvården, Region Halland
  Halmstad, Halland County, Sweden Recruiting
• Ambulanssjukvården Region Värmland
  Karlstad, Värmland County, Sweden Recruiting
• Ambulanshelikoptern (HEMS) Västra Götalandsregionen
  Kungälv, Västra Götaland County, Sweden Recruiting
• Sjukvården i väster
  Alingsås, Sweden Recruiting
• Emergency medical services, Södra Älvsborgs Sjukhus, Region Västra Götaland
  Borås, Sweden Recruiting
• Prehospital Intensive Care Unit (PIV) AnOPIVA Östra Sjukhuset/SU
  Gothenburg, Sweden Recruiting

Study contacts

• Principal investigator: Akil Awad, M.D. Ph.D. — Center for resuscitation Science. Department of clinical sience and education. Södersjukhuset, Karolinksa Institutet, Stockholm, Sweden
• Study coordinator: Gabriel Riva, M.D. Ph.D
• Email: gabriel.riva@ki.se
• Phone: + 47 70 545 20 86

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Initial double sequential defibrillation for out-of-hospital ventricular fibrillation

  This trial will test whether using two defibrillators to give double sequential shocks first improves survival for adults with out-of-hospital cardiac arrest and a shockable rhythm.

  Recruiting St. Olavs Hospital · Trondheim · NCT06672159

• Effect of early nasal cooling on survival after cardiac arrest

  This study is testing if cooling patients right after a cardiac arrest can help them survive better and recover their brain function compared to standard care.

  Recruiting at 15 sites Karolinska Institutet · Graz and 16 other locations · NCT06025123

• Assessing the benefits of ICD implantation in patients with coronary artery disease after cardiac arrest

  This study is testing if getting an implantable defibrillator helps people with coronary artery disease who have survived a cardiac arrest feel better and live longer.

  Recruiting Copenhagen University Hospital, Rigshospitalet · Copenhagen · NCT04576130

• Minimal Sedation After Out-of-Hospital Cardiac Arrest

  This study tests whether stopping continuous sedation right after return of circulation is as safe as keeping patients sedated in the early hours after OHCA.

  Recruiting University Medical Centre Ljubljana · Ljubljana · NCT07895771

• Risk of malignant arrhythmias after acute coronary syndrome

  This study tracks how often dangerous heart rhythms occur in adults admitted for ACS and looks for patterns that might predict them.

  Recruiting Catharina Ziekenhuis Eindhoven · Eindhoven, North Brabant · NCT07824050

• Predict Arrhythmia Risk with Intelligent Software

  Researchers are testing AI-powered predictions to see if clinicians can spot patients at risk for dangerous heart rhythms using bedside ECG data.

  Recruiting Catharina Ziekenhuis Eindhoven · Eindhoven, North Brabant · NCT07792694

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.