Comparing wrist denervation and exercise for wrist osteoarthritis
Partial Wrist Denervation Versus Self-managed Exercise Therapy in Patients with Wrist Osteoarthritis: a Randomized Controlled Multicenter Trial
NA · Karolinska Institutet · NCT06098586
This study is testing whether surgery to numb certain nerves in the wrist works better than a guided exercise program for people with wrist osteoarthritis.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 140 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Karolinska Institutet (other) |
| Locations | 2 sites (Malmö and 1 other locations) |
| Trial ID | NCT06098586 on ClinicalTrials.gov |
What this trial studies
This clinical trial is a randomized controlled trial that compares the effectiveness of partial wrist denervation to a self-managed exercise therapy program in patients with wrist osteoarthritis. The study aims to determine which treatment leads to better patient-reported outcomes, pain relief, grip strength, and range of motion. It involves 140 patients and is conducted at two centers in Sweden, utilizing a multicenter parallel group design with assessor blinding. Participants will either undergo surgery or follow a structured exercise program designed to improve wrist stability and function.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18 and older with chronic wrist pain due to specific types of osteoarthritis.
Not a fit: Patients with rheumatoid arthritis, other chronic inflammatory arthritis, or those who have had previous wrist surgeries may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide patients with effective treatment options for managing wrist osteoarthritis, potentially improving their quality of life.
How similar studies have performed: Other studies have shown varying degrees of success with similar approaches, but this specific comparison of wrist denervation and exercise therapy is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥ 18 years. * Chronic wrist pain (≥6 months) due to Scapholunate advanced collapse (SLAC) / Scaphoid non-union advanced collapse (SNAC) grade 1-3 osteoarthritis. * Radiological signs of osteoarthritis on posteroanterior and lateral radiograph. Exclusion Criteria: * Previous PIN or AIN neurectomy. * Rheumatoid arthritis or other chronic inflammatory arthritis. * Symptomatic osteoarthritis in the distal radio-ulnar (DRU), Scapho-trapezio-trapezoid (STT) or thumb carpometacarpal (CMC) joints. * Ongoing infection. * Inability to co-operate with the follow-up protocol. * Systemic or intra-articular glucocorticoids or intraarticular PRP or Hyaluronic acid injections in the affected joint within 3 months prior to enrollment.
Where this trial is running
Malmö and 1 other locations
- Department of hand surgery, Malmo university hospital — Malmö, Sweden (RECRUITING)
- Department of hand handsurgery, Södersjukhuset — Stockholm, Sweden (RECRUITING)
Study contacts
- Principal investigator: Elin Swärd, MD, PhD — Karolinska Institutet
- Study coordinator: Elin Swärd, MD, PhD
- Email: elin.sward@regionstockholm.se
- Phone: +4612360000
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Osteoarthritis Wrist