Innovative strategies to understand and combat severe dengue

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to identify biomarkers and host factors associated with the severity of dengue infections in patients from dengue-endemic regions. By employing multi-omics approaches, the study will analyze blood samples from individuals with dengue to uncover immune responses, disease pathogenesis, and cellular interactions. It will also investigate the impact of primary and secondary infections, virus serotypes, and immunological factors on disease progression. The findings are expected to enhance disease management, improve severity prediction, and identify potential therapeutic targets to prevent severe outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Group 1: Dengue without warning signs Patients presenting with the following symptoms confirmed positive for dengue infection by lab diagnosis by anti-dengue IgM or NS1 ELISA will be recruited for the study under this cohort.

Symptoms will be fever along with at least two of the following -

* Myalgia, arthralgia
* Nausea and/or vomiting
* Rashes
* Leukopenia Group 2: DENV with warning signs This cohort will include patients with the above symptoms and any of the following clinical signs.
* Abdominal pain with tenderness
* Persistent vomiting
* Fluid accumulation
* Mucosal bleeding
* Restlessness, lethargy
* Liver enlargement \>2cm
* Laboratory findings: An increase in hematocrit levels and a rapid decrease in platelet count Group 3: Severe dengue
* Severe plasma leakage leads to hypovolemic shock (dengue shock syndrome) and fluid accumulation with respiratory distress.
* Severe bleeding, such as epistaxis, internal bleeding, etc., is evaluated by a clinician.
* Severe organ involvement with any of the following symptoms
* Liver AST or ALT ≥ 1000
* CNS: impaired consciousness
* Heart and other organs failure

Exclusion Criteria:

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Where it's running

• Bio Box Guatemala Ong de Investigación, Servicios Y de Medio Ambiente
  Guatemala City, Guatemala Recruiting
• Manipal Academy of Higher Education (MAHE)
  Mangalore, Karnataka, India Recruiting

Study contacts

• Study coordinator: Ujjwal Neogi, PhD
• Email: ujjwal.neogi@ki.se
• Phone: +46 8524 83680

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.