Impact of mitral valve surgery on ventricular arrhythmias

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to evaluate how mitral valve surgery for mitral regurgitation affects ventricular arrhythmias and related biomarkers in patients with arrhythmogenic mitral valve prolapse (MVP). It will involve 90 patients, including those with and without arrhythmogenic MVP, who will undergo cardiac magnetic resonance imaging and continuous arrhythmic monitoring before and six months after surgery. The study will also analyze molecular characteristics of heart tissue to better understand the underlying mechanisms of arrhythmias in these patients.

Why it matters

Who can join: the full rules

Inclusion criteria

* Age 18 and over
* Patients with and without (controls) arrhythmogenic MVP in need of mitral valve surgery for primary mitral regurgitation according to current standard of care

Exclusion criteria

* Secondary mitral regurgitation
* Primary mitral regurgitation not due to degenerative disease (including rheumatic disease)
* Co-existing moderate or severe aortic valve disease
* Congenital heart disease
* Inherited or acquired cardiomyopathy
* Non-incidental or symptomatic coronary artery disease
* Uncontrolled atrial fibrillation (resting heart rate \> 100/min)
* Pregnancy
* Unable to undergo CMR

Where it's running

• Karolinska Univeristy Hospital
  Stockholm, Stockholm County, Sweden Recruiting

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.