Online therapy for anxiety after heart issues

Digital Cognitive Behavioral Therapy for Cardiac Anxiety Following Acute Coronary Syndrome: a Randomized Controlled Trial Comparing CBT to a Digital Lifestyle Intervention

Not applicable Interventional Karolinska Institutet · NCT06298864

This study is testing an online therapy program to see if it can help people recovering from heart issues feel less anxious and improve their quality of life.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment176 (estimated)
Ages18 Years and up
SexAll
SponsorKarolinska Institutet Academic / other
Locations1 site (Stockholm)
Trial IDNCT06298864 on ClinicalTrials.gov

What this trial studies

This study evaluates an online Cognitive Behavioral Therapy (CBT) program designed for patients recovering from Acute Coronary Syndrome (ACS) to reduce cardiac anxiety, improve quality of life, and encourage physical activity. Participants will be randomly assigned to either the internet-based CBT group or an active control group receiving internet-based cardiac lifestyle intervention. Both groups will receive weekly therapist support through online communication over an 8-week period. The study aims to determine the effectiveness of the online CBT protocol in alleviating anxiety and enhancing overall well-being in ACS patients.

Who should consider this trial

Good fit: Ideal candidates are adults aged 18 and older who have experienced ACS at least 6 months prior and are experiencing clinically significant cardiac anxiety.

Not a fit: Patients with severe heart failure, significant valvular disease, or ongoing psychological treatment may not benefit from this study.

Why it matters

Potential benefit: If successful, this intervention could significantly reduce cardiac anxiety and improve the quality of life for patients recovering from ACS.

How similar studies have performed: Previous studies have shown promise in using online CBT for anxiety management, suggesting potential success for this approach.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* ACS ≥ 6 months before assessment (type 1 MI STEMI/NSTEMI or unstable angina \[UA\])
* Age 18 and older
* Clinically significant cardiac anxiety that leads to distress and/or interferes with daily life (Cardiac Anxiety Questionnaire; CAQ: ≥18
* Able to read and write in Swedish

Exclusion Criteria:

* Heart failure New York heart Association class IV or ejection fraction ≤ 30%
* Significant valvular disease
* Planned coronary artery bypass surgery or percutaneous interventions
* Any medical restriction to physical exercise
* Severe medical illness or an acute health threatening disease (e.g., cancer)
* Grade 3 hypertension (i.e., blood pressure ≥ 180 systolic and/or 110 diastolic)
* Severe mental illness requiring urgent psychiatric hospitalization or intervention, or risk of suicide
* Alcohol or substance use disorder that would impede ability to complete study protocol
* Ongoing psychological treatment

Where this trial is running

Stockholm

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Acute Coronary SyndromeOnline CBT Targeting Cardiac AnxietyCardiac AnxietyACSInternet-CBTCBTSecondary prevention
Last reviewed 2026-06-09 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.