Improving prevention and care for pregnant and postpartum adolescent girls and young women with HIV in Tanzania

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This mixed-methods project combines a registry-based cohort analysis, qualitative interviews, and co-production workshops to optimize PMTCT care for adolescent girls and young women (AGYW) aged 15–24 with HIV. The cohort component follows AGYW who started PMTCT between 2018 and 2020 to measure appointment attendance, ART retention, viral suppression, infant HIV-free survival, and repeat pregnancy up to two years postpartum. Qualitative interviews with AGYW, healthcare providers, partners, parents, and community stakeholders will identify social and structural barriers to care. Findings will be used to co-design and pilot a package of interventions tailored to the needs and preferences of AGYW in the study regions.

Why it matters

Who can join: the full rules

Sub-study 1 (registry-based cohort analysis):

Inclusion Criteria:

* Pregnant/postpartum adolescent girls and young women (AGYW) with HIV aged 15-24 years, who started PMTCT services between January 1, 2018, and December 31, 2020.
* Infants born to the included AGYW during this period.

Exclusion Criteria:

* AGYW whose ART (Antiretroviral Therapy) status was not recorded.
* Women who had not started ART.

Sub-study 2 (qualitative):

Inclusion Criteria:

* AGYW living with HIV who are currently pregnant, previously pregnant/postpartum, and never pregnant).
* HCPs (Health Care Providers) at clinics providing PMTCT services.
* Spouses/partners/parents of AGYW and community stakeholders within the study setting.

Exclusion criteria

\- Mentally or severely ill individuals unable to participate in the study activities.

Sub-study 3 (co-production)

Inclusion criteria:

* AGYW, HCPs, spouses/partners, parents, and community stakeholders who participated in the qualitative study II.
* Research team members.

Exclusion criteria:

\- Mentally or severely ill individuals unable to participate in the study activities.

Sub-study 4 (cluster-randomized implementation trial)

Inclusion criteria:

\- Pregnant AGYW living with HIV (new, previously diagnosed, and transfers) receiving vertical HIV prevention services in routine healthcare between January 1, 2026, and June 30, 2026, and followed up for at least one year until June 30, 2027.

Exclusion criteria:

* AGYW whose ART (Antiretroviral Therapy) status was not recorded.

Where it's running

• Management and Development for Health
  Dar es Salaam, Tanzania Recruiting
• Management and Development for Health
  Kagera, Tanzania Recruiting

Study contacts

• Study coordinator: Anna E Kågesten, PhD
• Email: anna.kagesten@ki.se
• Phone: 0046707302287

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.