Comparing surgical and non-surgical treatments for finger osteoarthritis
Denervation for Osteoarthritis in the PIP-joint Efficacy Study (DOPS), a Randomized Controlled Trial
This study is testing whether surgery or non-surgical treatments like education and exercise work better for people with osteoarthritis in their finger joints.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 90 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Karolinska Institutet Academic / other |
| Locations | 1 site (Stockholm) |
| Trial ID | NCT05980793 on ClinicalTrials.gov |
What this trial studies
This clinical trial aims to evaluate the effectiveness of surgical denervation versus non-surgical treatment, which includes patient education and exercise, in patients suffering from osteoarthritis in the proximal interphalangeal (PIP) joint. Participants will be randomly assigned to one of the two treatment groups, and their pain levels, functional outcomes, grip strength, and range of motion will be assessed at baseline and at 3, 6, and 12 months post-intervention. The study seeks to determine if surgical intervention provides greater benefits compared to non-surgical methods. The primary endpoint will be evaluated 12 months after the intervention.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 and older with chronic symptomatic osteoarthritis in the PIP joint and radiological evidence of the condition.
Not a fit: Patients with inflammatory arthritis, ongoing infections in the hand, or those who have received certain injections in the affected joint within the last three months may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide patients with more effective treatment options for managing pain and improving function in finger osteoarthritis.
How similar studies have performed: Other studies have shown promising results with surgical interventions for osteoarthritis, but this specific comparison of surgical versus non-surgical treatment for PIP joint osteoarthritis is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥ 18 years. * Chronic symptomatic osteoarthritis in the PIP-joint. * Radiological signs of osteoarthritis on posteroanterior and lateral radiographs assessed by the Kellgren-Lawrence classification (grade II-IV) (Kellgren \& Lawrence, 1957). * Clinical signs of PIP-joint arthritis. Exclusion Criteria: * Inflammatory arthritis. * Ongoing infection in the hand. * Inability to co-operate with the follow-up protocol. * Intra-articular glucocorticoid, PRP or Hyaluronic acid injections in the affected joint less than 3 months prior to enrollment.
Where this trial is running
Stockholm
- Department of Hand Surgery, Södersjukhuset — Stockholm, Sweden (Recruiting)
Study contacts
- Principal investigator: Elin Sward, MD, PhD — Department of Hand Surgery Sodersjukhuset and Karolinska Institutet
- Study coordinator: Elin Sward, MD, PhD
- Email: elin.sward@regionstockholm.se
- Phone: +46812361000
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.