Gene-based grouping of bone and soft tissue tumors
Official title: Molekylära Och Kliniska Studier av Ben- Och mjukdelstumörer
Run by Karolinska Institutet · NCT07822204 · Data updated 2026-11-12
This study tests whether tumors of bone and soft tissue can be sorted into clearer genetic groups using DNA and RNA data.
Quick facts
| Study type | Observational |
|---|---|
| Sex | All |
| Enrollment | 50000 (estimated) |
| Sponsor | Karolinska Institutet Academic / other |
| Locations | 1 site (Stockholm) |
| Status | Recruiting |
| Started | March 1, 2026 |
| Main results expected | March 1, 2046 |
| Study ends | March 1, 2046 |
| Registry record updated | October 2, 2026 |
| Trial ID | NCT07822204 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Individuals of any age with a histopathologically diagnosed bone or soft tissue tumor, for whom tissue material is available for analysis at the study center.
✕Probably not a fit
Patients without retrievable tissue or who decline consent may not benefit from study findings.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study collects tumor tissue samples from patients with bone or soft tissue tumors to see if gene profiles can define new groupings that are clearer than traditional histology names. It compares gene-based groupings to the original diagnoses and tracks outcomes over time to see which sorting method best reflects tumor behavior. Researchers will also explore whether a computer program can distinguish these gene groups from scanned tissue images. The study will use methylation, whole transcriptome sequencing, and whole genome sequencing analyses on archived and prospective samples. Participants are drawn from Karolinska University Hospital and collaborating institutions in Sweden.
Why it matters
Potential benefit: If successful, patients may benefit from more precise tumor分類 and better-tailored management in the future.
How similar studies have gone: Prior work in molecular pathology suggests gene-based tumor classification can improve grouping beyond histology; this study builds on that approach in bone and soft tissue tumors.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Histopathologically diagnosed tumor or tumor-like lesion of bone or soft tissue, including benign, intermediate and malignant lesions * Tissue sampled, resected or reviewed at the study center * Archived diagnostic material available and adequate for the analyses of the relevant cohort: formalin-fixed paraffin-embedded tissue, fresh-frozen tissue, or diagnostic glass slides * For the prospective cohort, documented informed consent Exclusion Criteria: * No retrievable diagnostic material or diagnostic report * Documented objection by the participant to the research use of their material or data
Where it's running
-
Karolinska University Hospital
Stockholm, Sweden Recruiting
Study contacts
- Study coordinator: Felix Haglund de Flon, MD PhD, Associate Professor
- Email: felix.haglund@ki.se
- Phone: +46-8-524 800 00
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.