Following individuals with specific autoantibodies to understand disease progression

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study focuses on individuals who have tested positive for autoantibodies against Ro/SSA and La/SSB. Participants will be monitored to assess clinical manifestations and immunological parameters, aiming to identify changes and factors that may lead to the development of autoimmune diseases. The study seeks to enhance understanding of the transition from serological autoreactivity to clinically manifest disease, which is currently poorly understood. By investigating these aspects, the research aims to provide insights that could facilitate earlier diagnosis and treatment.

Why it matters

Who can join: the full rules

Inclusion Criteria:

To be included in the risk group, the following criteria must be met:

\- At least one instance of testing positive for Ro/SSA or La/SSB, regardless of the method used.

To be included in the control group, the individual must:

\- Have no rheumatologic disease and no autoantibodies against Ro/SSA or La/SSB.

Exclusion Criteria:

1. Below 18 years of age
2. Inability to consent to their own participation
3. Ongoing infection or severe illness where the study physician deems participation in the study not to be in the individuals best interest
4. Inability to read and understand Swedish, and therefore unable to complete the forms and questionnaires included in the project

Where it's running

• Centrum för reumatologi
  Stockholm, Sweden Recruiting

Study contacts

• Study coordinator: Albin Björk, MD, PhD
• Email: albin.bjork@ki.se
• Phone: +46 8-123 687 04

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.