Investigating fatigue and cognitive dysfunction in patients after stem cell transplantation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study follows patients who have undergone allogeneic stem cell transplantation to systematically measure fatigue and cognitive impairment using international standards. The study aims to validate previous findings regarding distinct mRNA and proteomic profiles that differentiate fatigued from non-fatigued patients. Researchers will analyze blood and cerebrospinal fluid samples to identify potential biomarkers for cognitive dysfunction and fatigue, employing advanced techniques such as mass spectrometry and Olink technology. Additionally, neurocognitive testing will be conducted to predict which patients may develop these conditions, contributing to a better understanding of their pathophysiology.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* status 1-5 years after HSCT
* no known CNS disorders or psychiatric disturbances

Exclusion Criteria:

* prior TBI or CNS irradiation / intrathecal therapy
* known neurological or psychiatric disorder
* time less then 1 year or over 5 years after transplantation

Where it's running

• Karolinska
  Stockholm, Sweden Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.