Effect of early nasal cooling on survival after cardiac arrest

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effectiveness of ultra-early transnasal evaporative cooling in patients who have experienced out-of-hospital cardiac arrest with an initial shockable rhythm. Participants will be randomized into two groups: one receiving immediate cooling treatment initiated by EMS personnel, and the other receiving standard normothermia. The primary outcome is to assess the difference in survival rates with complete neurologic recovery at 90 days post-arrest between the two groups. The study aims to determine if early cooling can improve outcomes compared to conventional treatment.

Why it matters

Who can join: the full rules

INCLUSION CRITERIA:

Patients ≥18 years that meet all of the following inclusion criteria:

1. Adult out-of-hospital cardiac arrest patients with initial shockable rhythm
2. Unconsciousness defined as Glasgow Coma Scale \< 8
3. Inclusion within 20 minutes from EMS arrival

EXCLUSION CRITERIA:

Patients are not eligible if they meet one or more of the following criteria:

1. Age ≥ 80 years
2. Obvious non-cardiac causes to cardiac arrest
3. Obvious already hypothermic
4. Obvious barrier to placing intra nasal catheters
5. Have a known Do Not Attempt to Resuscitate (DNAR) order or other limitations in care
6. Have a known terminal disease
7. Known or clinically apparent pregnancy

Where it's running

• Medizinische Universität Graz, Abteilung für Kardiologie
  Graz, Austria Recruiting
• University Hospital Vienna
  Vienna, Austria Recruiting
• CHU Saint-Pierre
  Brussels, Belgium Recruiting
• Erasme University Hospital
  Brussels, Belgium Recruiting
• Europe Hospitals St Elizabeth
  Brussels, Belgium Recruiting
• University Hospital Freiburg
  Freiburg im Breisgau, Germany Recruiting

Study contacts

• Principal investigator: Per Nordberg, MD, PhD — Karolinska Institutet
• Study coordinator: Per Nordberg, MD, PhD
• Email: per.nordberg@ki.se
• Phone: +46702802579

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.