Examining the effects of bariatric surgery on heart disease and mortality
Official title: The Causal Effect of Bariatric Surgery on Cardiovascular Disease and Mortality
Run by Karolinska Institutet · NCT06420479 · Data updated 2026-11-12
This study is trying to see if different types of weight-loss surgery can help people with obesity lower their risk of heart disease and live longer compared to those who don't have surgery.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 100000 (estimated) |
| Sponsor | Karolinska Institutet Academic / other |
| Locations | 1 site (Stockholm) |
| Status | Recruiting |
| Started | January 1, 2024 |
| Main results expected | December 31, 2027 |
| Study ends | December 31, 2027 |
| Registry record updated | June 17, 2024 |
| Trial ID | NCT06420479 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are men and women of reproductive age diagnosed with obesity who have no prior history of cardiovascular disease or cancer.
✕Probably not a fit
Patients with contraindications to bariatric surgery will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study investigates the causal effects of bariatric surgery on cardiovascular disease and mortality among individuals with obesity. It aims to determine the effectiveness of different types of bariatric surgery, specifically gastric bypass and sleeve gastrectomy, in reducing these health risks. Utilizing data from Swedish health registers, the study will compare outcomes between patients undergoing surgery and those receiving non-surgical obesity management, employing causal inference and machine learning techniques to analyze the results.
Why it matters
Potential benefit: If successful, this study could provide critical insights into how bariatric surgery can improve heart health and reduce mortality in obese patients.
How similar studies have gone: Other studies have shown promising results regarding the benefits of bariatric surgery on weight loss and related health outcomes, making this approach both relevant and potentially impactful.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Men and women of reproductive age with a diagnosis of obesity, no prior history of cardiovascular disease or cancer, and no contraindications for surgery after 1982 Exclusion Criteria: * Contraindications to bariatric surgery
Where it's running
-
Karolinska Institutet
Stockholm, Sweden Recruiting
Study contacts
- Study coordinator: Conor MacDonald, PhD
- Email: conor.macdonald@ki.se
- Phone: 0000
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Examining heart changes in patients undergoing rehabilitation or bariatric surgery
This study is testing how heart changes in people improve after they go through rehabilitation or weight-loss surgery to see if these changes can help spot heart problems early.
-
Examining gut microbiota changes in patients undergoing metabolic surgery
This study is testing how metabolic surgery affects gut bacteria and heart health in patients, especially focusing on the African American community, over the next 10 years.
-
Abnormal menstrual bleeding in women on antithrombotic drugs after heart surgery
This study looks at whether women on blood thinners after heart surgery have abnormal menstrual bleeding and what factors might put some at higher risk.
-
AI-powered ECG to help diagnose and predict outcomes in heart disease
Researchers test an AI-enhanced ECG to help diagnose and predict outcomes for people with cardiovascular diseases.
-
Colchicine for preventing cardiovascular disease in adults with type 2 diabetes
A 24-week study will test whether low-dose colchicine can help protect blood vessels in adults with type 2 diabetes who have not yet developed artery disease, compared with a placebo.
-
Optimised Cardio-Renal Care for CKD and heart disease
This study tests whether a specialised Cardio-Renal Clinic can improve heart and kidney health and quality of life for adults with chronic kidney disease and cardiovascular disease.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.