Examining the effects of bariatric surgery on heart disease and mortality
The Causal Effect of Bariatric Surgery on Cardiovascular Disease and Mortality
This study is trying to see if different types of weight-loss surgery can help people with obesity lower their risk of heart disease and live longer compared to those who don't have surgery.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 100000 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Karolinska Institutet Academic / other |
| Locations | 1 site (Stockholm) |
| Trial ID | NCT06420479 on ClinicalTrials.gov |
What this trial studies
This observational study investigates the causal effects of bariatric surgery on cardiovascular disease and mortality among individuals with obesity. It aims to determine the effectiveness of different types of bariatric surgery, specifically gastric bypass and sleeve gastrectomy, in reducing these health risks. Utilizing data from Swedish health registers, the study will compare outcomes between patients undergoing surgery and those receiving non-surgical obesity management, employing causal inference and machine learning techniques to analyze the results.
Who should consider this trial
Good fit: Ideal candidates for this study are men and women of reproductive age diagnosed with obesity who have no prior history of cardiovascular disease or cancer.
Not a fit: Patients with contraindications to bariatric surgery will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide critical insights into how bariatric surgery can improve heart health and reduce mortality in obese patients.
How similar studies have performed: Other studies have shown promising results regarding the benefits of bariatric surgery on weight loss and related health outcomes, making this approach both relevant and potentially impactful.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Men and women of reproductive age with a diagnosis of obesity, no prior history of cardiovascular disease or cancer, and no contraindications for surgery after 1982 Exclusion Criteria: * Contraindications to bariatric surgery
Where this trial is running
Stockholm
- Karolinska Institutet — Stockholm, Sweden (Recruiting)
Study contacts
- Study coordinator: Conor MacDonald, PhD
- Email: conor.macdonald@ki.se
- Phone: 0000
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.