Clinical trial Recruiting at 1 site Observational Ages 18 and up

Examining the effects of bariatric surgery on heart disease and mortality

Official title: The Causal Effect of Bariatric Surgery on Cardiovascular Disease and Mortality

Run by Karolinska Institutet · NCT06420479 · Data updated 2026-11-12

This study is trying to see if different types of weight-loss surgery can help people with obesity lower their risk of heart disease and live longer compared to those who don't have surgery.

More Cardiovascular Diseases trials

Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment100000 (estimated)
SponsorKarolinska Institutet
Academic / other
Locations1 site (Stockholm)
StatusRecruiting
StartedJanuary 1, 2024
Main results expectedDecember 31, 2027
Study endsDecember 31, 2027
Registry record updatedJune 17, 2024
Trial IDNCT06420479 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are men and women of reproductive age diagnosed with obesity who have no prior history of cardiovascular disease or cancer.

Probably not a fit

Patients with contraindications to bariatric surgery will not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates the causal effects of bariatric surgery on cardiovascular disease and mortality among individuals with obesity. It aims to determine the effectiveness of different types of bariatric surgery, specifically gastric bypass and sleeve gastrectomy, in reducing these health risks. Utilizing data from Swedish health registers, the study will compare outcomes between patients undergoing surgery and those receiving non-surgical obesity management, employing causal inference and machine learning techniques to analyze the results.

Why it matters

Potential benefit: If successful, this study could provide critical insights into how bariatric surgery can improve heart health and reduce mortality in obese patients.

How similar studies have gone: Other studies have shown promising results regarding the benefits of bariatric surgery on weight loss and related health outcomes, making this approach both relevant and potentially impactful.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Men and women of reproductive age with a diagnosis of obesity, no prior history of cardiovascular disease or cancer, and no contraindications for surgery after 1982

Exclusion Criteria:

* Contraindications to bariatric surgery

Where it's running

  • Karolinska Institutet
    Stockholm, Sweden
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.