Clinical trial Recruiting at 1 site Observational Ages 18 and up

Walking and Thinking: Brain Activity During Complex Walking After Stroke

Official title: Walking and Thinking - Brain Activity During Complex Walking in Stroke

Run by Karolinska Institutet · NCT07624630 · Data updated 2026-11-12

This study looks at how the brain works during tricky walking tasks in people who have had a stroke to understand motor and thinking together in real life movement.

Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment50 (estimated)
SponsorKarolinska Institutet
Academic / other
Locations1 site (Solna, Stockholm County)
StatusRecruiting
StartedAugust 1, 2026
Main results expectedJuly 1, 2027
Study endsJuly 1, 2027
Registry record updatedJune 3, 2026
Trial IDNCT07624630 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults 18 years or older who had a stroke at least 6 months ago and can walk for at least 5 minutes, with or without a walking aid.

Probably not a fit

Individuals with significant cognitive impairment, severe neglect, global aphasia affecting consent, or severe perceptual problems or freezing of gait may not benefit from this observational study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study uses functional near infrared spectroscopy (fNIRS) to observe brain activity while participants with prior stroke perform complex walking tasks that require both movement and cognition. It aims to uncover how dual-task walking and navigation engage brain networks in everyday mobility. No interventions are given; the focus is on capturing natural brain and gait patterns in ecologically valid settings. The findings could help tailor rehabilitation strategies that address motor-cognitive integration after stroke.

Why it matters

Potential benefit: If successful, results could inform personalized rehabilitation approaches that target motor-cognitive coordination to improve safe community walking.

How similar studies have gone: Previous studies using noninvasive brain imaging have shown feasible brain-behavior links in post-stroke gait tasks, supporting this approach's potential validity.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* 18 years or older
* with a stroke ≥6 months confirmed by a clinical diagnosis
* with the ability to walk with or without a walking aid for ≥ 5 min

Exclusion Criteria:

* Individuals post stroke with cognitive impairment
* severe neglect
* global aphasia affecting the ability to provide written informed consent
* severe perceptual problems or severe freezing of gait

Where it's running

  • uMOVE core facility, Karolinska Institutet and Karolinska University hospital
    Solna, Stockholm County, Sweden
    Recruiting

Study contacts

Similar studies

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.