Pain Reprocessing Therapy in a Specialist Pain Clinic
Official title: Breaking the Pain Cycle: Implementing a Novel Neuroscience-based Behavioral Therapy for Chronic Pain in a Pain Rehabilitation Setting
Run by Karolinska Institutet · NCT07791355 · Data updated 2026-11-12
This study tests Pain Reprocessing Therapy (PRT) to see if it can be feasibly used and how patients feel about it in a pain rehabilitation clinic for adults with chronic nociplastic or mixed pain.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 25 (estimated) |
| Sponsor | Karolinska Institutet Academic / other |
| Locations | 1 site (Stockholm) |
| Status | Recruiting |
| Started | August 2026 |
| Main results expected | July 2027 |
| Study ends | July 2027 |
| Registry record updated | August 27, 2026 |
| Trial ID | NCT07791355 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults 18 and older with chronic nociplastic or mixed chronic pain lasting at least 3 months, able to participate in highly specialized rehabilitation in a Swedish-speaking setting.
✕Probably not a fit
Patients with severe psychiatric conditions, active substance abuse, dementia, cancer-related pain, or recent psychological treatment for pain may not benefit from this intervention.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a single-arm pilot study to assess the feasibility, patient satisfaction, and acceptability of Pain Reprocessing Therapy (PRT) when delivered in a specialized pain rehabilitation setting. The trial will compare outcomes with a matched reference group from the Swedish Quality Registry for Pain Rehabilitation to provide context on potential effectiveness. Exploratory analyses will look for subgroups that may respond better to PRT and examine changes in pain intensity, function, kinesiophobia, catastrophizing, and mood. Participants are adults with chronic pain lasting at least three months, who have completed prior medical evaluation and can participate in Swedish-language rehabilitation. No randomization is used in this feasibility study, which focuses on implementation and patient/clinician acceptability rather than definitive efficacy.
Why it matters
Potential benefit: If successful, PRT could offer a new psychological approach that may reduce pain impact and improve function for adults with chronic nociplastic or mixed pain.
How similar studies have gone: PRT has shown promising results in similar chronic pain cohorts in the US, but this feasibility study explores implementation in a Swedish clinical context.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adults aged 18 years and older. * Completed medical investigation regarding the pain diagnosis. Primary pain conditions (according to ICD-11) or nociplastic pain, as well as mixed conditions where patients have nociplastic pain combined with nociceptive and/or neuropathic pain (e.g., fibromyalgia, chronic widespread pain, primary chronic back pain). * Pain duration of at least 3 months. * Current medication regimen compatible with participating in and benefiting from highly specialized rehabilitation. * Ability to read, speak, and understand the Swedish language. * Exclusion Criteria: * Severe psychiatric conditions (e.g., psychosis, severe depression, and suicidality). * Current substance abuse (including overuse of prescription medications) or dementia. * Cancer pain, cauda equina syndrome, or other medical conditions that constitute the primary explanation for the patient's pain. * Another psychological treatment for pain within the past 3 months. * Ongoing parallel treatments related to the patient's pain at other clinics, with the exception of ongoing pharmacological treatment. * Ongoing legal disputes or active claims for disability compensation.
Where it's running
-
Karolinska Institutet
Stockholm, Sweden Recruiting
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Cognitive Rehabilitation of Everyday Goals With GMT: How Different Ways of Delivery Work
This study tests Goal Management Training to see if a Swedish version helps adults with acquired brain injury or chronic pain improve practical goal-directed thinking and daily functioning.
-
One-time Pain Reprocessing Therapy session for chronic pain at The Ottawa Hospital
A single four-hour session of Pain Reprocessing Therapy is being tested to see if it can help adults with chronic pain feel better and have less pain.
-
Meaning-Based Psychotherapy for Adults with Chronic Pain
This trial tests whether Meaning-Based Psychotherapy helps adults with chronic pain feel more purposeful, feel less depressed, and have a better quality of life compared with optimized usual care therapy.
-
How chronic pain changes over time in kids with Duchenne Muscular Dystrophy
This study is following children and teens with Duchenne Muscular Dystrophy for 6 months to see how their chronic pain changes and how it affects daily life.
-
CBD for Opioid Dependence and Pain on Buprenorphine
This study tests whether different doses of cannabidiol (CBD) can affect pain and opioid cravings in adults with opioid use disorder who are on buprenorphine, using a short, randomized, placebo-controlled setup.
-
Cebranopadol for opioid withdrawal in adults with chronic pain
This study tests whether cebranopadol can reduce withdrawal symptoms in adults with chronic pain who are physically dependent on prescribed opioids, compared with placebo.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.