Investigating mortality and cardiovascular diseases in adults with type 1 diabetes
Cardiovascular Disease, Mortality and Prognostic Factors in Adult-onset Type 1 Diabetes
Karolinska Institutet · NCT06563401
This study looks at how type 1 diabetes affects the risk of dying and heart problems in adults compared to those with type 2 diabetes and people without diabetes.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 900000 (estimated) |
| Ages | 18 Years to 110 Years |
| Sex | All |
| Sponsor | Karolinska Institutet (other) |
| Locations | 1 site (Stockholm) |
| Trial ID | NCT06563401 on ClinicalTrials.gov |
What this trial studies
This observational study aims to assess the risk of all-cause mortality, cause-specific mortality, and cardiovascular diseases (CVD) in adults diagnosed with type 1 diabetes (T1D) compared to those with type 2 diabetes (T2D) and population controls. It will analyze data from the Swedish National Diabetes Registers, linking lifestyle factors, clinical characteristics, and treatment outcomes to understand the prognosis of adult-onset T1D. The study will also estimate life expectancy based on different ages at T1D diagnosis, providing insights into the long-term health implications of this condition.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18 years and older diagnosed with type 1 diabetes between 2001 and 2020.
Not a fit: Patients diagnosed with secondary diabetes due to pancreatic cancer or those with a recent history of digestive system cancers may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide critical insights into the prognosis of adult-onset type 1 diabetes, potentially leading to improved management strategies and better health outcomes for patients.
How similar studies have performed: Previous studies have indicated higher mortality risks in adult-onset T1D compared to T2D, suggesting that this study builds on existing knowledge but focuses on a less explored age group.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * people with adult-onset (≥18 years) T1D diagnosed in 2001-2020 from the National Diabetes Register * all T2D cases diagnosed at age ≥18 years in 2001-2020 recorded in the National Diabetes Register Everyone with T1D was matched by age, sex, and county to 50 population controls from the Total Population Register. Exclusion Criteria: * To avoid diabetes secondary to pancreatic cancer, we excluded people diagnosed with cancer in the digestive system 1 year prior to diabetes diagnosis and with pancreatic cancer as the underlying cause of death.
Where this trial is running
Stockholm
- Karolinska institute — Stockholm, Sweden (RECRUITING)
Study contacts
- Principal investigator: Sofia Carlsson, phd — sofia carlsson, senior lecturer, Karolinska Institutet
- Study coordinator: Sofia Carlsson, phd
- Email: sofia.carlsson@ki.se
- Phone: 0046 8 524 800 11
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Type 1 Diabetes, Type 2 Diabetes