Investigating mortality and cardiovascular diseases in adults with type 1 diabetes
Official title: Cardiovascular Disease, Mortality and Prognostic Factors in Adult-onset Type 1 Diabetes
Run by Karolinska Institutet · NCT06563401 · Data updated 2026-11-12
This study looks at how type 1 diabetes affects the risk of dying and heart problems in adults compared to those with type 2 diabetes and people without diabetes.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 110 Years |
| Sex | All |
| Enrollment | 900000 (estimated) |
| Sponsor | Karolinska Institutet Academic / other |
| Locations | 1 site (Stockholm) |
| Status | Recruiting |
| Started | January 1, 2024 |
| Main results expected | May 31, 2025 |
| Study ends | July 1, 2025 |
| Registry record updated | April 3, 2025 |
| Trial ID | NCT06563401 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adults aged 18 years and older diagnosed with type 1 diabetes between 2001 and 2020.
✕Probably not a fit
Patients diagnosed with secondary diabetes due to pancreatic cancer or those with a recent history of digestive system cancers may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to assess the risk of all-cause mortality, cause-specific mortality, and cardiovascular diseases (CVD) in adults diagnosed with type 1 diabetes (T1D) compared to those with type 2 diabetes (T2D) and population controls. It will analyze data from the Swedish National Diabetes Registers, linking lifestyle factors, clinical characteristics, and treatment outcomes to understand the prognosis of adult-onset T1D. The study will also estimate life expectancy based on different ages at T1D diagnosis, providing insights into the long-term health implications of this condition.
Why it matters
Potential benefit: If successful, this study could provide critical insights into the prognosis of adult-onset type 1 diabetes, potentially leading to improved management strategies and better health outcomes for patients.
How similar studies have gone: Previous studies have indicated higher mortality risks in adult-onset T1D compared to T2D, suggesting that this study builds on existing knowledge but focuses on a less explored age group.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * people with adult-onset (≥18 years) T1D diagnosed in 2001-2020 from the National Diabetes Register * all T2D cases diagnosed at age ≥18 years in 2001-2020 recorded in the National Diabetes Register Everyone with T1D was matched by age, sex, and county to 50 population controls from the Total Population Register. Exclusion Criteria: * To avoid diabetes secondary to pancreatic cancer, we excluded people diagnosed with cancer in the digestive system 1 year prior to diabetes diagnosis and with pancreatic cancer as the underlying cause of death.
Where it's running
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Karolinska institute
Stockholm, Sweden Recruiting
Study contacts
- Principal investigator: Sofia Carlsson, phd — sofia carlsson, senior lecturer, Karolinska Institutet
- Study coordinator: Sofia Carlsson, phd
- Email: sofia.carlsson@ki.se
- Phone: 0046 8 524 800 11
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.