Tracking physical activity changes in people with Parkinson's
Official title: Physical Activity in Persons With Parkinson's Disease - a Longitudinal Cohort Study
Run by Karolinska Institutet · NCT07585409 · Data updated 2026-11-12
This project will follow about 450 people with Parkinson's over four years using wearable activity monitors, clinical tests, and questionnaires to see which physical, cognitive, social, or environmental factors make people less active.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 450 (estimated) |
| Sponsor | Karolinska Institutet Academic / other |
| Locations | 1 site (Stockholm) |
| Status | Recruiting |
| Started | January 15, 2026 |
| Main results expected | December 31, 2030 |
| Study ends | January 30, 2031 |
| Registry record updated | May 15, 2026 |
| Trial ID | NCT07585409 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults diagnosed with idiopathic Parkinson's disease at Hoehn & Yahr stages 1–4 who can complete the required physical and clinical assessments are ideal candidates.
✕Probably not a fit
People who are wheelchair bound or bedridden (Hoehn & Yahr stage 5) or who cannot perform the critical physical assessments would not be eligible and are unlikely to benefit from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a national, multicentre longitudinal cohort that will enroll approximately 450 people with idiopathic Parkinson's disease across five Swedish regions, continuing an internal pilot. Physical activity will be measured objectively with accelerometers alongside repeated clinical assessments and digital questionnaires over four years. The primary outcome is change in accelerometer-measured physical activity, with exposure variables including physical, cognitive, disease-specific, social, environmental, motivational, and personal factors. Data collection combines clinical tests, patient-reported experience measures, and continuous activity-monitor data to identify patterns and predictors of declining activity.
Why it matters
Potential benefit: If successful, the findings could identify modifiable barriers and supports so clinicians can offer personalized strategies to help people with Parkinson's stay active.
How similar studies have gone: Previous smaller studies using accelerometers in Parkinson's have shown feasibility and links between symptoms and activity, but large multicentre, long-term cohorts like this are relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * People diagnosed with idiopathic Parkinson's disease * Hoehn \& Yahr 1 to 4 Exclusion Criteria: * Hoehn \& Yahr 5 (i.e. wheelchair bound or bedridden unless aided) * Unable to perform critical physical activity and clinical assessments
Where it's running
-
Karolinska University Hospital
Stockholm, Sweden Recruiting
Study contacts
- Principal investigator: Erika Franzén — Karolinska Institutet
- Study coordinator: Compliance Office Karolinska Insitutet
- Email: compliance@ki.se
- Phone: +46852480000
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.