Clinical trial Recruiting at 1 site Observational Ages 22 to 70 Women only

Risk of cervical cancer after HPV detection in healthy women

Official title: Risk of Cervical Cancer Following Incident, Persistent and History-unknown Human Papillomavirus (HPV) Detection by HPV Genotype

Run by Karolinska Institutet · NCT07850128 · Data updated 2026-11-12

This study tests how likely it is for cervical cancer to develop after different HPV detection patterns in healthy women who undergo HPV-based screening.

Quick facts

Study typeObservational
Ages22 Years to 70 Years
SexWomen only
Enrollment130000 (estimated)
SponsorKarolinska Institutet
Academic / other
Locations1 site (Stockholm)
StatusRecruiting
StartedOctober 31, 2025
Main results expectedNovember 3, 2025
Study endsDecember 2026
Registry record updatedSeptember 30, 2026
Trial IDNCT07850128 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Women aged 22–70 living in the Greater Stockholm Region who had a positive HPV test result at primary screening between 2014 and 2023.

Probably not a fit

Women without HPV detection or those outside the screening age or geographic area may not benefit.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a population-based, retrospective observational study using existing health registries in the Stockholm region. It examines incident, persistent, and history-unknown HPV detections by genotype to estimate short- and longer-term cancer risk. The analysis uses data from 2014–2023 when primary HPV screening was used, including women aged 22–70. No participants are contacted or required to perform tasks; data are drawn from routine screening records. The goal is to inform whether particular HPV findings require immediate clinical action or can wait until the next screening.

Why it matters

Potential benefit: If successful, the study could help personalize follow-up recommendations after HPV detection, potentially reducing unnecessary procedures and focusing care on higher-risk cases.

How similar studies have gone: Previous screening research using registry data has shown value in measuring HPV-related cancer risk, but this specific genotype-stratified, history-unknown assessment is exploratory.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Women living in the Great Stockholm Region in Sweden, at cervical screening ages (age 22-70 years), and having had an HPV positive result in primary HPV test during 2014-2023

Exclusion Criteria:

* Women without valid personal identity number in the population registry

Where it's running

  • Centre for Cervical Cancer Elimination, Department of Clinical Science, Intervention and Technology, Karolinska Institutet
    Stockholm, Sweden
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.