Risk of cervical cancer after HPV detection in healthy women
Official title: Risk of Cervical Cancer Following Incident, Persistent and History-unknown Human Papillomavirus (HPV) Detection by HPV Genotype
Run by Karolinska Institutet · NCT07850128 · Data updated 2026-11-12
This study tests how likely it is for cervical cancer to develop after different HPV detection patterns in healthy women who undergo HPV-based screening.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 22 Years to 70 Years |
| Sex | Women only |
| Enrollment | 130000 (estimated) |
| Sponsor | Karolinska Institutet Academic / other |
| Locations | 1 site (Stockholm) |
| Status | Recruiting |
| Started | October 31, 2025 |
| Main results expected | November 3, 2025 |
| Study ends | December 2026 |
| Registry record updated | September 30, 2026 |
| Trial ID | NCT07850128 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Women aged 22–70 living in the Greater Stockholm Region who had a positive HPV test result at primary screening between 2014 and 2023.
✕Probably not a fit
Women without HPV detection or those outside the screening age or geographic area may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a population-based, retrospective observational study using existing health registries in the Stockholm region. It examines incident, persistent, and history-unknown HPV detections by genotype to estimate short- and longer-term cancer risk. The analysis uses data from 2014–2023 when primary HPV screening was used, including women aged 22–70. No participants are contacted or required to perform tasks; data are drawn from routine screening records. The goal is to inform whether particular HPV findings require immediate clinical action or can wait until the next screening.
Why it matters
Potential benefit: If successful, the study could help personalize follow-up recommendations after HPV detection, potentially reducing unnecessary procedures and focusing care on higher-risk cases.
How similar studies have gone: Previous screening research using registry data has shown value in measuring HPV-related cancer risk, but this specific genotype-stratified, history-unknown assessment is exploratory.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Women living in the Great Stockholm Region in Sweden, at cervical screening ages (age 22-70 years), and having had an HPV positive result in primary HPV test during 2014-2023 Exclusion Criteria: * Women without valid personal identity number in the population registry
Where it's running
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Centre for Cervical Cancer Elimination, Department of Clinical Science, Intervention and Technology, Karolinska Institutet
Stockholm, Sweden Recruiting
Study contacts
- Study coordinator: Jiangrong Wang, PhD
- Email: jiangrong.wang@ki.se
- Phone: +46769309451
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.