Clinical trial Recruiting at 1 site Observational Ages 18 and up

Does preoperative physical activity help predict perioperative problems after non-cardiac surgery?

Official title: Perioperative Predictive Value of Physical Activity on Short- and Long-term Morbidity and Mortality

Run by Karolinska Institutet · NCT07603622 · Data updated 2026-11-12

This study tests whether self-reported physical activity before surgery adds to existing risk factors in predicting complications and death after elective non-cardiac surgery.

Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment50000 (estimated)
SponsorKarolinska Institutet
Academic / other
Locations1 site (Stockholm)
StatusRecruiting
StartedMay 1, 2026
Main results expectedOctober 31, 2026
Study endsNovember 30, 2026
Registry record updatedAugust 12, 2026
Trial IDNCT07603622 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults (18+) undergoing elective non-cardiac surgery at Karolinska University Hospital Solna or Huddinge.

Probably not a fit

Patients with very low baseline activity or those whose risk is driven by non-modifiable factors may see limited benefit from adding physical activity to risk prediction.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

In this observational cohort at two Karolinska sites, researchers will examine whether higher preoperative physical activity (MET-score) improves prediction of perioperative morbidity and mortality beyond standard risk factors. Data such as age, sex, BMI, comorbidities, ASA status, and MET-score from preoperative assessments will be analyzed to see if activity level helps forecast complications measured by days alive and at home up to 30 days and 365 days after surgery. The aim is to determine if physical activity can meaningfully refine risk stratification for patients facing elective procedures. The study builds on existing evidence that postoperative complications raise mortality risk and affect recovery trajectories.

Why it matters

Potential benefit: If successful, clinicians could better identify higher- and lower-risk patients using simple activity questions, potentially guiding preoperative optimization and shared decision-making.

How similar studies have gone: Previous perioperative studies show meaningful associations between activity-related factors and outcomes, supporting the potential value of this approach.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Elective non-cardiac surgery patients (equal to or over 18 years) at the two study sites, Karolinska University Hospital Solna and Karolinska University Hospital Huddinge

Exclusion Criteria:

* Patients under the age of 18, transplant, day surgery, acute surgery, anesthesia monitoring, brachy therapy and gamma knife interventions. In case of multiple surgeries, only the first will be included.

Where it's running

  • Karolinska Institutet
    Stockholm, Sweden
    Recruiting

Study contacts

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.