Does preoperative physical activity help predict perioperative problems after non-cardiac surgery?
Official title: Perioperative Predictive Value of Physical Activity on Short- and Long-term Morbidity and Mortality
Run by Karolinska Institutet · NCT07603622 · Data updated 2026-11-12
This study tests whether self-reported physical activity before surgery adds to existing risk factors in predicting complications and death after elective non-cardiac surgery.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 50000 (estimated) |
| Sponsor | Karolinska Institutet Academic / other |
| Locations | 1 site (Stockholm) |
| Status | Recruiting |
| Started | May 1, 2026 |
| Main results expected | October 31, 2026 |
| Study ends | November 30, 2026 |
| Registry record updated | August 12, 2026 |
| Trial ID | NCT07603622 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (18+) undergoing elective non-cardiac surgery at Karolinska University Hospital Solna or Huddinge.
✕Probably not a fit
Patients with very low baseline activity or those whose risk is driven by non-modifiable factors may see limited benefit from adding physical activity to risk prediction.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
In this observational cohort at two Karolinska sites, researchers will examine whether higher preoperative physical activity (MET-score) improves prediction of perioperative morbidity and mortality beyond standard risk factors. Data such as age, sex, BMI, comorbidities, ASA status, and MET-score from preoperative assessments will be analyzed to see if activity level helps forecast complications measured by days alive and at home up to 30 days and 365 days after surgery. The aim is to determine if physical activity can meaningfully refine risk stratification for patients facing elective procedures. The study builds on existing evidence that postoperative complications raise mortality risk and affect recovery trajectories.
Why it matters
Potential benefit: If successful, clinicians could better identify higher- and lower-risk patients using simple activity questions, potentially guiding preoperative optimization and shared decision-making.
How similar studies have gone: Previous perioperative studies show meaningful associations between activity-related factors and outcomes, supporting the potential value of this approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Elective non-cardiac surgery patients (equal to or over 18 years) at the two study sites, Karolinska University Hospital Solna and Karolinska University Hospital Huddinge Exclusion Criteria: * Patients under the age of 18, transplant, day surgery, acute surgery, anesthesia monitoring, brachy therapy and gamma knife interventions. In case of multiple surgeries, only the first will be included.
Where it's running
-
Karolinska Institutet
Stockholm, Sweden Recruiting
Study contacts
- Study coordinator: Max Bell, MD, PhD
- Email: max.bell@regionstockholm.se
- Phone: +46708278533
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.