Condition

Opioid Use Disorder clinical trials and research

• 141Clinical trials
• 438NIH research projects
• 2New in 30 days
• 10Countries

Newest Opioid Use Disorder clinical trials

All recruiting trials (141)

• CBD for Opioid Dependence and Pain on Buprenorphine

  This study tests whether different doses of cannabidiol (CBD) can affect pain and opioid cravings in adults with opioid use disorder who are on buprenorphine, using a short, randomized, placebo-controlled setup.

  Recruiting Early Phase 1 Yale University · West Haven, Connecticut · NCT07886606

• Cebranopadol for opioid withdrawal in adults with chronic pain

  This study tests whether cebranopadol can reduce withdrawal symptoms in adults with chronic pain who are physically dependent on prescribed opioids, compared with placebo.

  Recruiting at 2 sites Phase 2 Adneuris Therapeutics, Inc. · North Canton, Ohio and 1 other locations · NCT07874620

• emPath platform pilot to link and keep adults with opioid use disorder in care in Durham

  This pilot tests a mobile app and telemedicine approach to help adults with opioid use disorder start and stay in MOUD through community outreach in Durham, NC.

  Recruiting Duke University · Durham, North Carolina · NCT07810322

• CB1 Receptors in Opioid Use Disorder Measured with a PET Radioligand

  This study tests CB1 receptor availability in people with opioid use disorder starting opioid agonist therapy and compares them with healthy adults.

  Recruiting Phase 1 Yale University · New Haven, Connecticut · NCT07800520

• STORC: Training a support person plus patient navigation after birth

  We’re testing whether training a designated support person and using patient navigation after delivery helps people with opioid use disorder build recovery resources and stay in treatment.

  Recruiting Friends Research Institute, Inc. · Philadelphia, Pennsylvania · NCT07787039

• Personalized Addiction Treatment Enhancement for Opioid Use Disorder

  A digital platform run by peer recovery supporters will be tested to help adults with opioid use disorder who are on buprenorphine or methadone stay in treatment and improve outcomes.

  Recruiting Rhode Island Hospital · Providence, Rhode Island · NCT07778394

• Biomarkers for opioid use and pain response after trauma and surgery

  This study tests whether microRNA patterns can predict long-term opioid risk in adults after trauma or surgery.

  Recruiting University of California, San Diego · La Jolla, California · NCT07693270

• Postpartum Mom Power for Opioid Use Disorder

  This study tests a Mother Power parenting program in moms with opioid use disorder to see if it helps reduce cravings, stress, and improve brain responses to infant cues compared with enhanced usual care.

  Recruiting at 2 sites Stony Brook University · Ann Arbor, Michigan and 1 other locations · NCT07632053

• Buprenorphine access at syringe service programs to reduce overdoses

  This study tests whether offering buprenorphine directly at syringe service programs helps adults with opioid use disorder start and stay in treatment better than referring them to traditional clinics.

  Recruiting at 8 sites Montefiore Medical Center · Los Angeles, California and 7 other locations · NCT07631598

• Brain blood flow and oxygen use in newborns with prenatal opioid exposure

  The study tests a new optical device to see if brain blood flow and oxygen use differ in newborns exposed to opioids before birth compared with unexposed newborns.

  Recruiting Indiana University · Indianapolis, Indiana · NCT07610746

• Boosting medication start and stay rates for people with opioid use disorder by adding peer support at mobile clinics

  This project will test whether adding trained peer support specialists at Prisma Health mobile clinics helps adults with opioid use disorder start and stay on medication treatment.

  Recruiting Prisma Health-Upstate · Greenville, South Carolina · NCT07541417

• Bundled telehealth, peer support, and buprenorphine after ED discharge to prevent opioid overdoses

  This trial tests a bundled approach with telehealth, peer support, buprenorphine, and care linkage to see if it helps people who have overdosed and were discharged from the ED continue treatment and avoid repeat overdoses.

  Recruiting Phase 4 University of Alabama at Birmingham · Birmingham, Alabama · NCT07485335

• EMS-initiated buprenorphine for opioid use disorder

  This study tests whether starting buprenorphine in EMS encounters helps people stay in treatment or connect to ongoing care for opioid use disorder.

  Recruiting at 3 sites Yale University · Oakland, California and 2 other locations · NCT07475728

• Canadian Emergency Department Opioid Registry (CEDRN)

  This project will create a national emergency department registry to collect information on people of all ages who come to EDs with suspected or confirmed opioid poisoning to see if those data can guide better care and prevent deaths.

  Recruiting University of British Columbia · Vancouver, British Columbia · NCT07466784

• Symptom‑inhibited naloxone induction to start buprenorphine/naloxone

  This study will try giving small, repeated IV doses of naloxone to trigger brief mild withdrawal so adults with opioid use disorder can begin buprenorphine safely, with an option for a long‑acting buprenorphine injection.

  Recruiting Phase 4 University of British Columbia · Vancouver, British Columbia and 1 other locations · NCT07439549

• Mailing buprenorphine after hospital discharge

  This pilot will test whether mailing buprenorphine to adults with opioid use disorder after medical hospitalization helps them stay in treatment.

  Recruiting Early Phase 1 Medical University of South Carolina · Charleston, South Carolina and 1 other locations · NCT07421102

• Brenipatide added to buprenorphine for people with opioid use disorder

  This will test whether brenipatide, given with buprenorphine (with or without naloxone), is safe and helpful for people with opioid use disorder who still use non-prescribed opioids.

  Recruiting at 54 sites Phase 2 Eli Lilly and Company · Phoenix, Arizona and 67 other locations · NCT07420283

• Mindfulness-Enhanced Ketamine Therapy for Opioid Use Disorder

  This trial tests whether adding Mindfulness-Oriented Recovery Enhancement (MORE) to Ketamine-Assisted Psychotherapy helps people with opioid use disorder who are on MOUD reduce opioid use and cravings.

  Recruiting at 2 sites Phase 2 University of California, San Diego · La Jolla, California and 1 other locations · NCT07369089

• Telehealth treatment for opioid use disorder in adults

  This trial tests whether using the RecoveryPad telehealth platform helps adults with moderate to severe opioid use disorder.

  Recruiting Yale University · New Haven, Connecticut · NCT07362082

• Brief alcohol-focused program tailored for people taking buprenorphine

  This project will try a short, opioid-informed alcohol counseling program for adults on prescribed buprenorphine who drink alcohol to see if it reduces drinking and helps them stay in treatment.

  Recruiting University of Notre Dame · Notre Dame, Indiana · NCT07342504

• Mild electrical brain stimulation (tDCS) with cognitive training to reduce cocaine cravings.

  This trial will test whether brief sessions of mild electrical brain stimulation (tDCS) combined with cognitive reappraisal training can lower craving in adults receiving inpatient treatment for cocaine use disorder.

  Recruiting Icahn School of Medicine at Mount Sinai · New York, New York · NCT07318480

• Decision aid to help emergency department patients choose whether to start buprenorphine

  This project tests a short decision aid to help adults with moderate-to-severe opioid use disorder in the emergency department understand buprenorphine and decide whether to start it.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT07278518

• Scaling NavSTAR patient navigation across a health system

  This project will test whether NavSTAR, a hospital-to-community patient navigation program, helps adults with moderate-to-severe opioid use disorder start and stay in opioid agonist treatment after discharge.

  Recruiting Friends Research Institute, Inc. · Philadelphia, Pennsylvania · NCT07262190

• Impact of MOUD Policy Changes During the Pandemic on Opioid and Alcohol Use Disorders

  This study tests how federal and state policy changes during the COVID-19 pandemic affected access to and use of medications for opioid use disorder among Veterans with opioid or alcohol use disorders.

  Recruiting Boston University · Boston, Massachusetts · NCT07232641

• Helping opioid treatment clinics track and improve patient retention

  This project tests whether giving opioid treatment clinics retention and outcome measures plus a quality-improvement toolkit, with or without extra coaching, helps people stay on methadone or buprenorphine.

  Recruiting RTI International · Research Triangle Park, North Carolina · NCT07214389

• Peer recovery support to help people stay on medication for opioid use disorder

  This project will see if meeting with trained peer recovery supporters helps people with opioid use disorder stay on their medication treatment.

  Recruiting Geisinger Clinic · Danville, Pennsylvania · NCT07197801

• Women-focused overdose prevention during jail-to-community re-entry in Kentucky

  This study tests an overdose prevention package for women leaving jail in rural Kentucky to see if it lowers overdose risk and improves treatment linkage.

  Recruiting at 3 sites University of Kentucky · Barbourville, Kentucky and 2 other locations · NCT07179614

• Monthly extended-release Buprenorphine given via a mobile clinic for opioid use disorder

  This project tests whether monthly extended-release subcutaneous buprenorphine can be feasibly and acceptably delivered from a mobile pharmacy clinic to people with opioid use disorder.

  Recruiting Phase 4 Yale University · New Haven, Connecticut · NCT07176351

• TMS to help recovery in people with opioid and alcohol use disorders

  This study tests whether short daily TMS sessions can help people with opioid and alcohol use disorders improve recovery outcomes when added to their regular treatment.

  Recruiting Washington State University · Portland, Oregon · NCT07171359

• Telehealth buprenorphine care for people with opioid use disorder in vulnerable settings

  This project will see if Boulder Care's telehealth platform can deliver buprenorphine treatment effectively to people with opioid use disorder in vulnerable communities.

  Recruiting Phase 1 Boulder Care · Portland, Oregon · NCT07169409

• Combining tDCS with cognitive training for people on buprenorphine for opioid use disorder

  This study will test whether adding mild brain stimulation (tDCS) combined with cognitive training helps people on buprenorphine for opioid use disorder reduce cravings and support recovery.

  Recruiting Phase 1 University of Minnesota · Minneapolis, Minnesota · NCT07158853

• AvertD device follow-up for adults starting an oral opioid

  This study will see if using the AvertD risk‑assessment device when adults are first prescribed a short oral opioid course works well, changes prescribing decisions, and helps people understand the device labeling.

  Recruiting Prescient Medicine Holdings, Inc. · Indianapolis, Indiana · NCT07135323

• Ketone supplements to help curb opioid cravings during withdrawal

  This study tests whether taking a ketone supplement three times daily for seven days can reduce opioid cravings and withdrawal symptoms in adults with opioid use disorder who are staying at a treatment center.

  Recruiting Phase 2 University of Maryland, Baltimore · Wernersville, Pennsylvania · NCT07128524

• Stepped care to improve MOUD retention for women with OUD, PTSD, and IPV history

  This study tests whether a stepped care program combining Present-Centered Therapy and HOPE can help women on medication for opioid use disorder who experienced intimate partner violence stay in treatment longer and reduce PTSD-related problems.

  Recruiting at 2 sites Yale University · Bridgeport, Connecticut and 2 other locations · NCT07115030

• ADTPM 1 auricular neurostimulation for opioid withdrawal symptoms

  This trial will test whether daily ear (auricular) neurostimulation with the ADTPM 1 device helps adults experiencing opioid withdrawal.

  Recruiting Nu Eyne Co., Ltd. · Daegu, Daegu · NCT07079215

• Social functioning and recovery for people with opioid use disorder

  This project will see if smartwatch data and daily surveys from people on buprenorphine and a close supporter can identify social behaviors linked to better treatment outcomes.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT07044466

• Coordinating outpatient buprenorphine care after an ED visit

  This study tests a bundle of strategies to improve how EDs link patients who start buprenorphine to outpatient care, to see if it helps people stay on treatment longer.

  Recruiting at 2 sites University of California, Davis · El Centro, California and 3 other locations · NCT07024498

• Technology-enhanced therapy compared with medication monitoring to help pregnant people stay on buprenorphine

  This project will see if a short therapy program plus a mobile app helps pregnant people on buprenorphine stay on their medication better than medication monitoring.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT06999811

• Lemborexant for insomnia in adults with opioid use disorder on buprenorphine

  This trial will see if taking lemborexant each night for 8 weeks improves sleep, mood, and impulsive behavior in adults with moderate opioid use disorder who are stable on buprenorphine.

  Recruiting Phase 2 Virginia Commonwealth University · Richmond, Virginia · NCT06981195

• Penny COPILOT texting support for pregnant and postpartum people with opioid use disorder

  This project will try a two-way SMS chatbot called Penny COPILOT to provide support and improve engagement for pregnant and postpartum people with opioid use disorder.

  Recruiting University of Pennsylvania · Philadelphia, Pennsylvania and 1 other locations · NCT06969261

• Telehealth versus in-person follow-up for buprenorphine after an emergency department visit

  This project will test whether arranging follow-up buprenorphine care by telehealth or by in-person clinics leads to better long-term treatment retention and patient experience for adults with opioid use disorder who start buprenorphine in the emergency department.

  Recruiting at 3 sites University of California, Davis · El Centro, California and 2 other locations · NCT06961058

• Resilience in people with opioid use disorder

  This project will test whether short lab tasks performed during stress and non‑stress sessions match up with self‑rated resilience in adults with opioid use disorder.

  Recruiting Johns Hopkins University · Baltimore, Maryland and 1 other locations · NCT06954402

• Using buprenorphine for pain relief after ankle fracture surgery

  This study tests if a skin patch with buprenorphine can help manage pain after ankle fracture surgery for patients who haven't used opioids before, while also looking at safety and the risk of addiction.

  Recruiting Phase 4 Washington University School of Medicine · St Louis, Missouri · NCT06949826

• Low-dose ketamine to reduce opioid craving in people starting methadone

  This test gives adults starting methadone either a low or very low dose of ketamine to see if it reduces opioid craving and withdrawal symptoms.

  Recruiting Phase 2 University of Maryland, Baltimore · Baltimore, Maryland · NCT06943859

• Injectable buprenorphine options to support release from prison

  This trial tests whether two long-acting buprenorphine injections help people with opioid use disorder stay in treatment after leaving prison, and whether letting people choose their injection improves retention.

  Recruiting Phase 4 Lifespan · Cranston, Rhode Island · NCT06880718

• Integrating social risk information into opioid treatment in the emergency department

  This study is testing a new tool that adds social risk information to help emergency department patients with opioid use disorder stick to their treatment plans better.

  Recruiting University of California, San Francisco · San Francisco, California · NCT06872190

• Brain training to help with opioid addiction

  This study is testing if brain training games can help people with opioid addiction by reducing their cravings for drugs.

  Recruiting Neurotype Inc. · Minneapolis, Minnesota · NCT06870110

• Peer-led harm reduction intervention for opioid use disorder in hospitals

  This study is testing a new peer support program in hospitals to see if it can help people with opioid use disorder have fewer overdoses and infections compared to regular care.

  Recruiting University of Pennsylvania · Pittsburgh, Pennsylvania and 2 other locations · NCT06843213

• Daily bright-light glasses to improve sleep and recovery in people with opioid use disorder

  This trial will test whether wearing AYO bright-light glasses each morning can improve sleep patterns and support recovery in adults receiving medication for opioid use disorder.

  Recruiting University of Alabama at Birmingham · Birmingham, Alabama · NCT06832007

• Adaptive interventions for patients with opioid use disorder in the emergency department

  This study is testing a new way to help adults with opioid use disorder in the emergency department by offering different types of support to see if it encourages them to keep using buprenorphine for their recovery.

  Recruiting Rand · Colton, California · NCT06827288

• Psilocybin effects on motivation and cognitive flexibility in opioid use disorder

  This study will test whether a low (1 mg) or high (25 mg) dose of psilocybin changes brain circuits tied to motivation and decision-making in adults with opioid use disorder who are in residential treatment.

  Recruiting Phase 2 University of Pennsylvania · Philadelphia, Pennsylvania · NCT06810310

• Understanding pain avoidance in people with opioid use disorder

  This study looks at how people with opioid use disorder learn to avoid pain compared to healthy individuals to better understand their condition.

  Recruiting Yale University · New Haven, Connecticut · NCT06800703

• Improving decision support for opioid addiction treatment

  This study is testing ways to improve a system that helps emergency department staff give buprenorphine to people with opioid addiction to make sure they get the right treatment.

  Recruiting at 3 sites Yale University · Guilford, Connecticut and 2 other locations · NCT06799117

• Psilocybin treatment for opioid use disorder

  This trial will test whether moderate or high doses of psilocybin, compared with a very low-dose control, help adults with opioid use disorder who continue to use illicit opioids despite taking methadone.

  Recruiting at 5 sites Phase 2 NYU Langone Health · Albuquerque, New Mexico and 4 other locations · NCT06796062

• Expanding support for adolescents with opioid use disorder

  This study is testing a new way to support teenagers with opioid use disorder by involving their families and making it easier for them to stick to their treatment.

  Recruiting Potomac Health Foundations · Baltimore, Maryland · NCT06774248

• Support for people recovering from opioid overdoses in Seattle

  This study tests a new support center for people recovering from opioid overdoses in Seattle to see if it helps them get better care and stay safe compared to those who don’t use the center.

  Recruiting University of Washington · Seattle, Washington · NCT06768814

• Using a virtual conversational helper to keep people on buprenorphine engaged in care

  This study will try a smartphone-based animated virtual assistant to help people on buprenorphine for opioid use disorder stay in treatment.

  Recruiting Boston Medical Center · Boston, Massachusetts · NCT06732596

• Injectable versus sublingual buprenorphine for people using fentanyl and other potent synthetic opioids

  This project will test whether a long-acting injectable buprenorphine or daily sublingual buprenorphine/naloxone works better at reducing drug use and preventing relapse in adults who use fentanyl or other high‑potency synthetic opioids.

  Recruiting Early Phase 1 Columbia University · New York, New York · NCT06726200

• Digital intervention to reduce alcohol use in patients receiving opioid treatment

  This study tests a digital program designed to help people in opioid treatment reduce their heavy drinking and improve their overall health.

  Recruiting Ohio State University · Columbus, Ohio · NCT06718491

• Peer recovery support services to help individuals with opioid use disorder start medication treatment

  This study is trying to see if having support from peers can help people with opioid use disorder start medication treatment while they are in residential care.

  Recruiting Potomac Health Foundations · Baltimore, Maryland · NCT06696157

• Tirzepatide with buprenorphine for opioid use disorder

  This trial will test whether adding weekly tirzepatide injections to buprenorphine helps adults with moderate to severe opioid use disorder stay in treatment, reduce opioid use, and improve sleep.

  Recruiting at 9 sites Phase 2 University of Cincinnati · Jacksonville, Florida and 8 other locations · NCT06651177

• Autobiographical memory in people with opioid use disorder

  This trial tests whether a four-week at-home memory-training program (MemFlex) can improve memory and related symptoms in adults with opioid use disorder while measuring brain and heart activity before and after.

  Recruiting University of Pennsylvania · Philadelphia, Pennsylvania · NCT06643988

• Guanfacine plus mindfulness to support buprenorphine treatment for opioid use disorder.

  This trial will test whether adding the medication guanfacine and a mindfulness program to buprenorphine helps adults with opioid use disorder reduce cravings and stay in treatment.

  Recruiting Phase 1 Rutgers, The State University of New Jersey · Newark, New Jersey · NCT06642181

• Therapy for Opioid Use Disorder and PTSD

  This study is testing a new therapy called HOPE to see if it helps people with both opioid use disorder and PTSD feel better when combined with their current medication.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT06641115

• Semaglutide to support recovery from opioid use disorder

  This 12-week test tries weekly semaglutide injections in people with opioid use disorder who recently started buprenorphine to see if it reduces cue-reactivity and improves symptoms and safety measures.

  Recruiting Phase 2 Brigham and Women's Hospital · Boston, Massachusetts · NCT06639464

• Improving opioid treatment quality and jail-to-community care connections for people leaving jail

  This project will test whether a package of systems-engineering tools (SAIA) helps jails and community clinics connect people leaving jail to medications for opioid use disorder.

  Recruiting University of Washington · Seattle, Washington · NCT06593353

• Using brain scans and magnetic stimulation to help people quit opioids

  This study is testing if brain scans can help predict how well people with opioid use disorder will do in quitting opioids when they start treatment with buprenorphine, and if adding a special brain stimulation can make the treatment work better.

  Recruiting Duke University · Durham, North Carolina · NCT06585709

• Improving care for mothers with opioid use disorder and their infants in NICUs

  This study is trying to see if a new treatment plan for mothers with opioid use disorder can help them and their babies in the NICU feel better and get the care they need.

  Recruiting at 3 sites University of Pennsylvania · Philadelphia, Pennsylvania and 2 other locations · NCT06576323

• Training peer recovery coaches and an AI texting platform to improve buprenorphine access for Black and Latinx adults with opioid use disorder

  This project will test whether short video training for peer recovery coaches combined with an AI-driven texting tool helps Black and Latinx adults with opioid use disorder start buprenorphine and connect to social services.

  Recruiting Friends Research Institute, Inc. · New York, New York · NCT06573476

• Culturally tailored pain and opioid treatment for Indigenous communities

  This study is testing a new approach to help American Indian and Alaska Native communities manage chronic pain and opioid use by using care that respects their culture and improves how healthcare providers are trained.

  Recruiting University of New Mexico · Arcata, California and 2 other locations · NCT06565416

• Methadone Patient Access to Collaborative Treatment

  This trial tests a program called MPACT to see if it helps people stay in methadone treatment and reduces overdoses, while also examining how staff and patient stress affect implementation.

  Recruiting University of Arizona · Tucson, Arizona · NCT06556602

• Using semaglutide to help reduce opioid use in patients undergoing treatment for opioid use disorder

  This study is testing if the medication semaglutide can help adults in outpatient treatment for opioid use disorder reduce their use of illicit opioids.

  Recruiting at 3 sites Phase 2 Milton S. Hershey Medical Center · Baltimore, Maryland and 3 other locations · NCT06548490

• Using THC and CBD to treat chronic pain and opioid cravings

  This study is testing if a mix of THC and CBD can help people with chronic pain and opioid cravings feel better while they are on methadone.

  Recruiting Phase 2 Yale University · New Haven, Connecticut · NCT06544291

• Using Tezampanel to treat opioid withdrawal in patients with opioid use disorder

  This study is testing if a new medication called Tezampanel can help people with opioid use disorder feel better during withdrawal.

  Recruiting Phase 1 Proniras Corporation · Indianapolis, Indiana · NCT06538558

• Clinical Decision Support to Help Treat Opioid Use Disorder

  Aimed at primary care patients using opioids, this study tests a CDS alert and a care pathway to help doctors identify and treat opioid use disorder with approved medications.

  Recruiting University of Colorado, Denver · Aurora, Colorado · NCT06526286

• Integrated care for hospitalized patients with opioid and stimulant use disorders and infections

  This study tests if a new combined care approach for patients with infections from using opioids or stimulants can help them stay healthier and avoid going back to the hospital compared to regular treatment.

  Recruiting at 4 sites University of Maryland, Baltimore · Washington D.C., District of Columbia and 3 other locations · NCT06513156

• Comparing standard and high doses of buprenorphine for opioid use disorder treatment

  This study is testing whether a standard or higher dose of buprenorphine helps people with opioid use disorder start treatment and feel better within 10 days.

  Recruiting at 5 sites Phase 3 Yale University · Oakland, California and 4 other locations · NCT06494904

• Measuring physiological symptoms during opioid withdrawal and cravings

  This study is testing how the body reacts during opioid withdrawal and cravings in people with opioid dependence by using smartwatches to track their heart rate, skin temperature, and other signals over two weeks.

  Recruiting Spark Biomedical, Inc. · Center City, Minnesota and 1 other locations · NCT06487533

• Helping people in treatment for opioid use disorder disclose their history

  This study tests a new way to help people in treatment for opioid use disorder share their experiences to see if it improves their recovery and support from others.

  Recruiting University of Delaware · Wilmington, Delaware · NCT06458985

• Intervention for opioid use disorder and loneliness

  This study is testing whether different types of therapy can help people with opioid use disorder who feel lonely improve their social connections and overall health.

  Recruiting University of Rochester · Rochester, New York · NCT06458335

• Using focused ultrasound to treat pain, anxiety, and opioid cravings

  This study is testing whether a new ultrasound treatment can help people with opioid use disorder, chronic back pain, and anxiety feel less pain, reduce anxiety, and curb cravings for opioids.

  Recruiting Washington D.C. Veterans Affairs Medical Center · Washington D.C., District of Columbia · NCT06453109

• Using brain stimulation to reduce opioid relapse

  This study is testing if a brain stimulation technique can help people who are trying to overcome opioid addiction by reducing cravings and preventing relapse while they are on treatment.

  Recruiting Butler Hospital · Providence, Rhode Island · NCT06432465

• Better Together: integrating buprenorphine care in community settings

  A multi-site program tests whether delivering buprenorphine MOUD in nonmedical community sites with on-site Recovery Guiding improves 24-week retention compared with standard hub-clinic MOUD.

  Recruiting at 4 sites Howard University · Washington D.C., District of Columbia and 3 other locations · NCT06416020

• Starting buprenorphine treatment for opioid use disorder in patients using fentanyl

  This study tests if starting buprenorphine treatment for people with opioid use disorder who are using fentanyl can be done safely without causing withdrawal symptoms.

  Recruiting Phase 2 University of Pennsylvania · Philadelphia, Pennsylvania · NCT06379984

• HEAT telemedicine program for HIV and addiction care

  This project will try a telemedicine program to deliver addiction treatment to adults living with HIV in Alabama who report opioid or stimulant misuse.

  Recruiting University of Alabama at Birmingham · Birmingham, Alabama · NCT06370481

• Examining brain function and memory in relation to opioid use and childhood experiences

  This study is trying to see how tough childhood experiences affect brain function and memory in adults with opioid use disorder compared to healthy adults.

  Recruiting University of Michigan · Ann Arbor, Michigan · NCT06355778

• Examining opioid use in adolescents after surgery

  This study looks at how surgery-related opioid use affects teenagers aged 12-17 and aims to find out what factors might lead to opioid use disorder after their surgery.

  Recruiting Boston Children's Hospital · Aurora, Colorado and 4 other locations · NCT06350409

• Evaluating a new method for observing methadone treatment remotely

  This study tests a new online tool called Sonara to see if it can help people with opioid use disorder stick to their methadone treatment better than the usual methods.

  Recruiting Phase 2 Sonara Health · Chicago, Illinois · NCT06338280

• Comparing office-based methadone and buprenorphine for treating opioid use disorder

  This study is testing whether getting methadone or buprenorphine in a doctor's office helps people with opioid use disorder stay in treatment longer.

  Recruiting at 6 sites Phase 4 Yale University · Oakland, California and 5 other locations · NCT06323824

• Engagement of community health workers to support recovery from substance use disorders

  This study is testing whether support from community health workers can help people with substance use disorders engage better in treatment and improve their recovery experience after visiting the emergency department.

  Recruiting University of California, Los Angeles · Providence, Rhode Island · NCT06320015

• Testing higher doses of buprenorphine for treating opioid use disorder

  This study tests if a higher daily dose of buprenorphine can help people with opioid use disorder, especially those who have used fentanyl, feel better and stay in treatment longer compared to the standard dose.

  Recruiting Phase 2/3 Rhode Island Hospital · Providence, Rhode Island · NCT06316830

• Preventing opioid use disorder in homeless youth

  This study is testing different support methods to help homeless youth avoid opioid use and improve their mental health.

  Recruiting at 2 sites Ohio State University · Columbus, Ohio and 1 other locations · NCT06311838

• Monthly extended‑release buprenorphine versus daily sublingual buprenorphine for jailed adults with opioid use disorder

  This project will test whether monthly extended‑release buprenorphine or daily sublingual buprenorphine helps adults with moderate-to-severe opioid use disorder who are about to be released from jail stay in treatment and avoid relapse.

  Recruiting at 2 sites Phase 3 Friends Research Institute, Inc. · Baltimore, Maryland and 1 other locations · NCT06306443

• Telemedicine therapy for PTSD in people with opioid use disorder

  This study is testing a new telemedicine therapy for people with opioid use disorder and PTSD to see if it helps them feel better and stick with their treatment.

  Recruiting University of Vermont · Burlington, Vermont · NCT06288711

• Using focused ultrasound to treat severe opioid use disorder

  This study is testing whether low intensity focused ultrasound can help people aged 22 to 60 with severe opioid use disorder who haven't had success with other treatments.

  Recruiting West Virginia University · Morgantown, West Virginia · NCT06218706

• Tracking brain changes in people undergoing treatment for opioid use disorder

  This study is trying to see how brain changes in people getting treatment for opioid use disorder with methadone happen over time to help improve future treatments.

  Recruiting Yale University · New Haven, Connecticut · NCT06207162

• Exploration of Synaptotrophic Effects of Psilocybin in Opioid Use Disorder (OUD)

  This study is testing if psilocybin can help improve brain function in people struggling with opioid use disorder.

  Recruiting Phase 1 Yale University · New Haven, Connecticut · NCT06160284

• Smartphone behavioral sleep therapy for people starting buprenorphine for opioid use disorder

  This project will test a smartphone app that delivers cognitive behavioral therapy for insomnia and other sleep supports for adults beginning buprenorphine for opioid use disorder who have poor sleep.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT06157840

• Using brain and cognitive tools to understand opioid use disorder

  This study is trying to see how opioid use disorder affects thinking and decision-making in people who are stable on medication, to help improve treatment success and prevent relapse.

  Recruiting University of Pennsylvania · Philadelphia, Pennsylvania · NCT06136247

• Investigating how opioid use affects sleep and circadian rhythms

  This study is trying to see how opioid use affects sleep and body clock patterns in people with opioid use disorder to find better ways to help them recover.

  Recruiting University of Alabama at Birmingham · Birmingham, Alabama · NCT06104280

• Translating and validating a questionnaire for opioid misuse in Swedish pain patients

  This study is testing a new Swedish questionnaire to see if it can help identify opioid misuse among pain patients who are using opioids for treatment.

  Recruiting Uppsala University · Uppsala, Uppland · NCT06084520

• Using psilocybin to enhance buprenorphine treatment for opioid use disorder

  This study is testing if a single high dose of psilocybin can help people in outpatient buprenorphine treatment for opioid use disorder feel better and stick to their treatment plan.

  Recruiting Phase 2 Johns Hopkins University · Baltimore, Maryland · NCT06067737

• Starting monthly extended‑release buprenorphine (XRB) when someone is booked into jail

  This project will try switching adults booked into jail who are already taking daily sublingual buprenorphine to a monthly injected buprenorphine at admission versus continuing daily sublingual, to see which helps people leave jail with ongoing buprenorphine and stay in treatment.

  Recruiting at 4 sites Phase 4 NYU Langone Health · Boston, Massachusetts and 3 other locations · NCT06051890

• Understanding addiction in opioid users through a comprehensive approach

  This study looks at how serious opioid addiction is and what factors affect it in people using safe injection sites in France, while also checking their blood for clues that might help understand and predict their addiction over two years.

  Recruiting at 3 sites University Hospital, Strasbourg, France · Bron and 2 other locations · NCT06021548

• Using Facebook to help American Indian women recover from opioid use

  This study is testing whether a Facebook group can help American Indian women who are recovering from opioid use feel more supported and connected during their recovery journey.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT05995886

• Using cannabis oil to support opioid addiction treatment

  This study is trying out a balanced cannabis oil to see if it can help people with opioid addiction who are also getting treatment with methadone.

  Recruiting Phase 2 BC Centre on Substance Use · Vancouver, British Columbia · NCT05985850

• Predicting and preventing adverse outcomes of opioid use disorder in pregnant women

  This study is trying to see how genetic factors affect the health of pregnant women with opioid use disorder and their babies while they are being treated with medication.

  Recruiting University of Pittsburgh · Pittsburgh, Pennsylvania · NCT05942313

• Non-invasive treatment for opioid withdrawal using vagal nerve stimulation

  This study is testing whether a non-invasive treatment using Vagal Nerve Stimulation can help people with opioid use disorders feel better during withdrawal and reduce cravings.

  Recruiting at 5 sites Phase 3 Emory University · Atlanta, Georgia and 5 other locations · NCT05834478

• Evaluating the effects of suvorexant on drug demand in people with opioid use disorder

  This study is testing if the sleep medication suvorexant can help people with opioid use disorder reduce their cravings for drugs.

  Recruiting Early Phase 1 University of Maryland, Baltimore · Baltimore, Maryland · NCT05829655

• Access to HIV prevention and opioid use disorder treatment for people who inject drugs

  This study is testing a new way to help people who inject drugs get better access to HIV prevention and treatment for opioid use disorder by using peer support and mobile phone tools.

  Recruiting at 2 sites Boston Medical Center · Boston, Massachusetts and 1 other locations · NCT05769218

• Effects of cannabis on opioid withdrawal in individuals with opioid use disorder

  This study is testing whether inhaled cannabis can help people with opioid use disorder feel better during withdrawal.

  Recruiting Phase 1 University of Kentucky · Lexington, Kentucky · NCT05729932

• Using e-cigarettes to help smokers with opioid use disorder reduce smoking

  This study is testing if using e-cigarettes can help people with opioid use disorder who smoke to cut down on their cigarette use more effectively than just getting counseling and nicotine replacement therapy.

  Recruiting Phase 2 NYU Langone Health · New York, New York and 1 other locations · NCT05722561

• Examining cannabinoid receptor function in opioid use disorder

  This study is trying to see how cannabinoid receptors work in the brains of people with opioid use disorder compared to healthy individuals.

  Recruiting Phase 1 Yale University · New Haven, Connecticut · NCT05683184

• Improving HIV prevention for people who inject drugs on PrEP

  This study is testing new ways to help people who inject drugs and are on HIV prevention medication to better understand and use information about staying safe from HIV.

  Recruiting Phase 4 University of Connecticut · New Haven, Connecticut · NCT05669534

• Community partnerships to address the opioid crisis

  This study is testing a new online program that helps people recovering from opioid use disorder fix small legal issues that might be holding them back.

  Recruiting at 2 sites University of Michigan · Ann Arbor, Michigan and 1 other locations · NCT05665179

• Parenting intervention for mothers with opioid use disorder

  This study is testing a parenting program called 'Mom Power' to see if it can help mothers with opioid use disorder improve their drug use, mood, and parenting skills in the first six months after giving birth.

  Recruiting at 2 sites Stony Brook University · Ann Arbor, Michigan and 1 other locations · NCT05614661

• High dose buprenorphine induction for opioid use disorder in the emergency department

  This study is testing if a higher dose of buprenorphine can help people with opioid use disorder in the emergency department feel better and stay engaged in treatment.

  Recruiting Phase 3 Rutgers, The State University of New Jersey · Newark, New Jersey · NCT05589181

• Expanding access to opioid addiction treatment in Central Asia

  This study is trying to see if improving access to opioid addiction treatment can help people in Central Asia who inject drugs and are at risk for HIV.

  Recruiting at 3 sites Yale University · New Haven, Connecticut and 3 other locations · NCT05579470

• Innovative e-Health interventions for HIV and substance use in women involved in the justice system

  This study is testing a new online tool to help women in the justice system access HIV prevention and opioid treatment more easily, comparing it to a simpler version of the tool.

  Recruiting at 2 sites Phase 4 Yale University · Birmingham, Alabama and 1 other locations · NCT05547048

• Using buspirone to help with opioid withdrawal

  This study is testing if the medication buspirone can help people with opioid use disorder feel less withdrawal symptoms and cravings while they are tapering off opioids.

  Recruiting Phase 2 University of Maryland, Baltimore · Baltimore, Maryland · NCT05511909

• Cortical rTMS for Depression

  This study tests repetitive transcranial magnetic stimulation (rTMS) targeting the orbitofrontal cortex to see if it improves depressive symptoms in adults with major depressive disorder, including those with opioid use and suicidality considerations.

  Recruiting Baylor College of Medicine · Houston, Texas · NCT05487911

• Evaluating daily dosing methods of methadone for pain and opioid use disorder

  This study is testing whether taking methadone once or twice a day can better help people with chronic pain and opioid use disorder who are already on methadone treatment.

  Recruiting Phase 2/3 University of Maryland, Baltimore · Baltimore, Maryland · NCT05459402

• Low-dose buprenorphine for treating opioid use disorder

  This study is testing if starting treatment for opioid use disorder with low-dose buprenorphine is safe and effective compared to standard treatment, while tracking participants' symptoms and cravings using their mobile phones.

  Recruiting Phase 4 Montefiore Medical Center · The Bronx, New York · NCT05450718

• MDMA therapy for new mothers with PTSD and opioid addiction

  This study is testing if MDMA-assisted therapy can help new mothers with PTSD and opioid addiction feel better and improve their bond with their babies.

  Recruiting Phase 2 University of New Mexico · Albuquerque, New Mexico · NCT05219175

• Improving access and recovery for people with opioid use and mental health disorders

  This study is testing a new team approach combined with medication to see if it helps people with both opioid use and mental health issues recover better than just using medication alone.

  Recruiting at 5 sites University of Massachusetts, Worcester · Holyoke, Massachusetts and 4 other locations · NCT05138614

• Using smartphones to help recover from opioid addiction

  This study tests if a smartphone app can help people recovering from opioid addiction by giving doctors better information to adjust their treatment and see if it leads to less use of illegal opioids.

  Recruiting Phase 3 NYU Langone Health · Piscataway, New Jersey and 1 other locations · NCT05033028

• Evaluating opioid withdrawal symptoms during medication tapering

  This study is testing how different people experience withdrawal symptoms when they slowly reduce their opioid use under medical supervision to help improve treatment for opioid use disorder.

  Recruiting Phase 2 University of Maryland, Baltimore · Baltimore, Maryland · NCT05027919

• Combining Buprenorphine and XR-Naltrexone for Opioid Use Disorder Treatment

  This study is testing if combining two medications, buprenorphine-naloxone and XR-naltrexone, can help people with opioid use disorder stay in treatment longer, feel less cravings, and improve their mood.

  Recruiting Phase 2/3 New York State Psychiatric Institute · Rockville, Maryland and 1 other locations · NCT05011266

• Comparing microdosing and standard dosing of buprenorphine/naloxone for opioid use disorder in emergency departments

  This study is testing whether a smaller dose of buprenorphine/naloxone can help adults with opioid use disorder start and stick with their treatment better than the usual dose when they come to the emergency department.

  Recruiting at 5 sites Phase 2/3 University of British Columbia · Calgary, Alberta and 5 other locations · NCT04893525

• Ketamine-assisted therapy for opioid addiction

  This study is testing whether adding ketamine to a mindfulness therapy can help people with opioid addiction feel better compared to just the mindfulness therapy alone.

  Recruiting Phase 1/2 University of Utah · Salt Lake City, Utah · NCT04892251

• Community-based program for youth with opioid use disorder

  This study is testing a community program that helps young people with opioid use disorder get better treatment and support to see if it keeps them engaged in recovery and reduces overdoses.

  Recruiting Phase 4 The University of Texas Health Science Center, Houston · Houston, Texas · NCT04811014

• Vaccine to treat opioid-use disorder

  This study is testing a new vaccine to see if it can help people with opioid-use disorder by reducing the effects of oxycodone.

  Recruiting Phase 1/2 New York State Psychiatric Institute · Eatontown, New Jersey and 1 other locations · NCT04458545

• Using brain stimulation to treat opioid addiction and chronic pain

  This study is testing if a new brain stimulation treatment can help people with opioid addiction and chronic pain feel better compared to a placebo.

  Recruiting at 3 sites Case Western Reserve University · Hinsdale, Illinois and 2 other locations · NCT04379115

• Comparing oral and injectable buprenorphine for treating opioid use disorder in veterans

  This study is testing whether a long-acting injectable form of buprenorphine helps veterans with opioid use disorder stay in treatment and stay off opioids better than the usual daily pill form.

  Recruiting at 17 sites Phase 4 VA Office of Research and Development · Tuscaloosa, Alabama and 24 other locations · NCT04375033

• Deep brain stimulation for opioid use disorder

  This study is testing whether deep brain stimulation can help people who haven't had success with other treatments for opioid addiction by reducing cravings and relapses.

  Recruiting Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute) · Pittsburgh, Pennsylvania · NCT04354077

• Using focused ultrasound to treat opioid and substance use disorders

  This study is testing whether a new ultrasound treatment can help people with opioid and substance use disorders feel better and manage their conditions safely.

  Recruiting at 3 sites InSightec · Tampa, Florida and 3 other locations · NCT04197921

• Support program for young adults recovering from opioid use disorder

  This study is testing a new support program to help young adults aged 18-28 with opioid use disorder stick to their treatment and feel more engaged in their recovery.

  Recruiting Potomac Health Foundations · Baltimore, Maryland · NCT04173416

• Combining Psilocybin with Buprenorphine for Opioid Use Disorder

  This study is testing if adding psilocybin to buprenorphine treatment can help adults with opioid use disorder feel better and improve their quality of life.

  Recruiting Phase 1 University of Wisconsin, Madison · Madison, Wisconsin · NCT04161066

• Understanding Opioid Use Disorder in Pregnant Women and Its Effects on Infants

  This study looks at how opioid use during pregnancy affects mothers and their babies, trying to see if certain factors can help identify women who might not respond well to treatment.

  Recruiting University of Pittsburgh · Pittsburgh, Pennsylvania · NCT03923374

• Implementing HIV testing in opioid treatment programs

  This study is testing if coaching programs can help people in opioid treatment programs get more HIV and Hepatitis C tests and connect to care.

  Recruiting Columbia University · New York, New York · NCT03135886

• Imaging cannabinoid receptors in the brain using PET scans

  This study is trying to see how many cannabinoid receptors are in the brains of healthy people and those with conditions like cannabis use disorders or PTSD using special brain scans.

  Recruiting Yale University · New Haven, Connecticut · NCT01730781

NIH-funded research (newest 40 of 438)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Systems analysis to improve opioid use disorder care after jail release (SAIA-MOUD)

  A program to help people with opioid use disorder get better, faster, and safer care after they leave jail.

  NIH research University of Washington · Seattle, United States · NIH-11599161

• Precise epigenetic drugs for opioid addiction

  A tiny, targeted drug approach is being developed to help people with opioid use disorder by rewriting the epigenetic signals in the brain to reduce cravings and relapse risk.

  NIH research Boston Interactome, INC. · Boston, United States · NIH-11578588

• Increasing Access to Medications for Opioid Use Disorder for Unhoused Montanans

  This project helps unhoused people in Montana get life-saving medicines for opioid use disorder through clinics connected to syringe service programs, a nurse-led MOUD model, and peer support.

  NIH research Open Aid Alliance · Missoula, United States · NIH-11578581

• Optimizing long-acting PrEP and opioid treatment for people in jails and prisons

  This project tests a real-world approach to using long-acting PrEP and buprenorphine for HIV prevention and opioid treatment among incarcerated individuals and after release.

  NIH research Duke University · Durham, United States · NIH-11565766

• Scaling up medications for opioid use disorder in residential treatment programs

  This grant studies how to help residential treatment programs provide medications for opioid use disorder to reduce overdoses after discharge, focusing on real-world settings and policies.

  NIH research Rutgers Biomedical and Health Sciences · Newark, UNITED STATES · NIH-11535207

• Increasing Capacity at a Native Community Clinic to Improve Opioid Care for urban AI/AN

  This grant helps a Native American health clinic build its research capacity to better serve urban American Indian and Alaska Native people dealing with opioid use disorder and related health issues.

  NIH research Native American Community Clinic · Minneapolis, United States · NIH-11533803

• Multimodal fetal and placental imaging to predict outcomes in infants exposed to opioids

  This project uses brain and placenta imaging plus biomarkers to understand how prenatal opioid exposure affects babies and how to predict and improve outcomes for infants born to mothers with opioid use disorder.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11518816

• Safer ibogaine-based medicine for opioid use disorder

  A new synthetic iboga alkaloid candidate, GM-3009, is being developed to treat opioid use disorder with fewer safety risks and better effectiveness.

  NIH research Gilgamesh Pharma INC · New York, United States · NIH-11513538

• Improving care for opioid use disorder in the ICU

  This project helps hospital staff in intensive care units provide better care for patients with opioid use disorder.

  NIH research Mainehealth · Portland, United States · NIH-11477142

• Pain sensitivity, alcohol analgesia, and heavy drinking in people with opioid use disorder

  A short, patient-friendly look at how pain sensitivity and alcohol’s pain-relieving effects might influence heavy drinking in people with opioid use disorder.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11461099

• Health impacts of housing programs for people who are homeless and use opioids

  This project follows people who are homeless and use opioids to see how different housing and treatment policies affect overdose and health outcomes.

  NIH research Boston Medical Center · Boston, United States · NIH-11459532

• Opioid Use Disorder County Prevalence Using Recapture Estimates (OUD CAPTURE)

  Aimed at estimating how common opioid use disorder is across counties using advanced statistical methods to help target treatment and resources.

  NIH research University of Kentucky · Lexington, United States · NIH-11457463

• Team-based care for pregnant women with opioid use disorder in rural clinics

  A team-based care model is being adapted for rural obstetric settings to help pregnant women with opioid use disorder start and continue medications and improve health outcomes for them and their babies.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11454658

• Digital toolkit to improve IPV screening and care in opioid use disorder

  A digital toolkit helps clinics screen for intimate partner violence and connect people with IPV-related care for those being treated for opioid use disorder.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-11454644

• Mobile health support for people with opioid use disorder and PTSD after residential treatment

  A mobile health tool will help adults with opioid use disorder and PTSD stay connected to support after they leave residential treatment.

  NIH research University of Rhode Island · Kingston, United States · NIH-11454643

• Understanding withdrawal circuits in opioid use disorder and how to interrupt relapse

  Researchers are studying specific brain circuits related to withdrawal in opioid use disorder to identify targets that could help prevent relapse.

  NIH research Washington State University · Pullman, United States · NIH-11447945

• Medications for opioid use disorder in older adults with multiple health issues

  This project looks at how older adults living with opioid use disorder and multiple chronic conditions respond to medications for opioid use disorder.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11447399

• Oral health effects of buprenorphine and methadone in people with opioid use disorder

  This project will explore how common MOUD medicines like buprenorphine (including dissolvable forms) and methadone may affect oral health in people with opioid use disorder.

  NIH research Chestnut Health Systems, INC. · Bloomington, United States · NIH-11427115

• Psilocybin and opioid use disorder: a crossover trial to understand how psilocybin might help reduce relapse risk

  A Johns Hopkins-led study will test whether a single high dose of psilocybin can change withdrawal and craving in adults with opioid use disorder, using a careful crossover design to compare two doses.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11425436

• Antibody treatment that soaks up fentanyl to prevent overdoses

  A new antibody medicine that soaks up fentanyl and similar opioids is being developed to protect people at high risk of overdose.

  NIH research Mclean Hospital · Belmont, United States · NIH-11422441

• How Medicaid expansion could help recently released people get medications for opioid use disorder and mental health care

  This grant studies how extending Medicaid after release from jail or prison could help people with opioid use disorder and mental health needs stay on treatment and avoid overdose.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11422049

• High-Dose Medications for Opioid Use Disorder and Retention in Care

  This project tests whether adjusted, higher-dose MOUD regimens can help people stay in treatment and reduce overdose risks during the fentanyl crisis.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11422040

• RNA location and local protein-making in brain circuits tied to opioid use disorder

  A study exploring how RNA localization and local protein production in brain cells contribute to lasting brain changes and relapse risk in people with opioid use disorder.

  NIH research Trustees of Indiana University · Bloomington, United States · NIH-11420281

• Bright light therapy to improve sleep and recovery in opioid use disorder

  This project tests whether morning bright light therapy can improve sleep, circadian rhythms, brain signaling, and treatment outcomes for people with opioid use disorder.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11417330

• SHE-OUD: a quick, private screen-and-help program for women in opioid treatment

  A brief, computer-based screening and intervention is tested to help women with opioid use disorder who have experienced sexual violence and PTSD, aiming to improve their treatment outcomes.

  NIH research Rhode Island Hospital · Providence, United States · NIH-11415934

• Improving Access to Medications for Opioid Use Disorder in Medicare Beneficiaries

  This project aims to make FDA-approved medications for opioid use disorder more accessible to people covered by Medicare.

  NIH research Rand Corporation · Santa Monica, United States · NIH-11413739

• Housing and opioid treatment strategies to improve health for people experiencing homelessness and opioid use disorder

  A Stanford-led project will model how housing and opioid treatment interventions could reduce HIV, HCV, and related diseases among people who are unhoused and struggle with opioid use disorder.

  NIH research Stanford University · Stanford, United States · NIH-11411062

• Cannabinoid CB2 receptor activators for opioid use disorder

  A new treatment approach uses a CB2 receptor activator to reduce cravings and drug reward in people with opioid use disorder.

  NIH research Longieva Therapeutics · Menlo Park, United States · NIH-11410429

• Medicaid coverage of reentry health supports for opioid use disorder after prison release

  A mentored research grant explores how Medicaid-backed post-incarceration health navigation and social-linkage services affect care and outcomes for people with opioid use disorder after they leave prison.

  NIH research Baystate Medical Center, INC. · Springfield, United States · NIH-11408810

• Transforming how we measure opioid use disorder and expand life-saving care

  This project will combine health data from several countries to better estimate how many people have opioid use disorder and how well treatment and prevention efforts are working.

  NIH research University of New South Wales · Sydney, Australia · NIH-11408702

• HEALing Measurement Center: Improving opioid use disorder care with better measurement in Pennsylvania

  A Pennsylvania effort to improve opioid use disorder treatment by using measurement-based care to keep people in recovery and reduce overdose deaths.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11408540

• Optimizing opioid treatment for people leaving prison

  This project tests simple screening and a small diagnostic checklist to help identify opioid use disorder in prisoners and link them to medication for opioid use disorder (MOUD) when they’re released.

  NIH research University of Washington · Seattle, United States · NIH-11406216

• Secure remote methadone dispensing with home monitoring to improve opioid use disorder care

  A new project tests a home-based, tech-enabled way to dispense liquid methadone and monitor treatment remotely to help people with opioid use disorder access effective medication.

  NIH research Sano Healthcare Consultants, LLC · Ontario, UNITED STATES · NIH-11405774

• Novel 5-HT2A/mGluR5 blocker for opioid use disorder

  A new drug candidate targeting serotonin and mGluR5 receptors is being studied to help people with opioid use disorder alongside existing treatments.

  NIH research Virginia Commonwealth University · Richmond, United States · NIH-11403955

• Optimizing methadone treatment for opioid use disorder with fentanyl exposure

  This project aims to improve methadone treatment strategies for adults with opioid use disorder who are dealing with fentanyl in the drug supply.

  NIH research Brown University · Providence, United States · NIH-11402768

• Localize Opioid Use Disorder care to improve access to medication

  A project to map and monitor how easy it is for people with opioid use disorder to get medications, and to tailor services to improve access.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11401889

• Telehealth support for opioid use disorder in vulnerable settings

  A telehealth program is being tested to help people with opioid use disorder get buprenorphine treatment in settings where care is hard to reach, like jails, EDs, rural areas, and other vulnerable places.

  NIH research Boulder Care, INC. · Portland, UNITED STATES · NIH-11401058

• Sleep data that predict opioid treatment outcomes

  A big multi-site study will look at sleep and circadian patterns to help predict how well people with opioid-use disorder do when on standard treatments.

  NIH research Harvard Pilgrim Health Care, INC. · Canton, UNITED STATES · NIH-11398231

• Combined brain stimulation and cognitive training for opioid use disorder on buprenorphine

  A new program tests whether non-invasive brain stimulation plus thinking-training can help people on buprenorphine recover from opioid use disorder.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11398020

• Flexible methadone take-home dosing to keep people in treatment

  A large, real-world study tests whether making take-home methadone more flexible helps people stay in treatment for opioid use disorder.

  NIH research New York University School of Medicine · New York, United States · NIH-11396986

Related topics

Quick answers

How many Opioid Use Disorder clinical trials are recruiting right now?

141, as of November 12, 2026. 2 of them were first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 10 countries. The most sites are in United States (134 trials), Canada (5 trials), South Korea (1 trial), Sweden (1 trial), Kazakhstan (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 20, Phase 4: 12, Phase 1: 9, Phase 3: 5. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

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