Adaptive interventions for patients with opioid use disorder in the emergency department
Official title: Adaptive Interventions for Emergency Department Patients With Opioid Use Disorder
Run by Rand · NCT06827288 · Data updated 2026-11-12
This study is testing a new way to help adults with opioid use disorder in the emergency department by offering different types of support to see if it encourages them to keep using buprenorphine for their recovery.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 500 (estimated) |
| Sponsor | Rand Academic / other |
| Locations | 1 site (Colton, California) |
| Status | Recruiting |
| Started | October 4, 2024 |
| Main results expected | June 30, 2027 |
| Study ends | March 31, 2028 |
| Registry record updated | February 19, 2026 |
| Trial ID | NCT06827288 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adults aged 18 or older who present to the emergency department with a probable diagnosis of opioid use disorder.
✕Probably not a fit
Patients who do not have a diagnosis of opioid use disorder or are unable to provide informed consent may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
The ADAPT-ED study is designed to develop an adaptive intervention aimed at increasing long-term buprenorphine use among adults presenting to the emergency department with probable opioid use disorder. It employs a sequential multiple assignment randomized trial (SMART) methodology, which includes two stages of intervention. The first stage involves treatment initiation through either a Substance Use Navigator or a combination of this navigator with immediate telehealth access to outpatient providers. Non-responders in the second stage will receive either ongoing treatment from an emergency department-based team or enhanced support with behavioral health services.
Why it matters
Potential benefit: If successful, this study could significantly improve long-term treatment outcomes for patients with opioid use disorder by increasing buprenorphine use.
How similar studies have gone: Other studies have shown promise in using adaptive interventions for substance use disorders, suggesting that this approach may be effective.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Presented for ED care at ARMC * Age 18 or older * Probable OUD diagnosis * Speak and understand English or Spanish * Have capacity to give informed consent * Provide a signed and dated informed consent form
Where it's running
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Arrowhead Regional Medical Center
Colton, California, United States Recruiting
Study contacts
- Study coordinator: Mariah Kalmin, PhD
- Email: mariahk@rand.org
- Phone: 310-393-0411
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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CBD for Opioid Dependence and Pain on Buprenorphine
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emPath platform pilot to link and keep adults with opioid use disorder in care in Durham
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CB1 Receptors in Opioid Use Disorder Measured with a PET Radioligand
This study tests CB1 receptor availability in people with opioid use disorder starting opioid agonist therapy and compares them with healthy adults.
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STORC: Training a support person plus patient navigation after birth
We’re testing whether training a designated support person and using patient navigation after delivery helps people with opioid use disorder build recovery resources and stay in treatment.
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Personalized Addiction Treatment Enhancement for Opioid Use Disorder
A digital platform run by peer recovery supporters will be tested to help adults with opioid use disorder who are on buprenorphine or methadone stay in treatment and improve outcomes.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.