Clinical trial Recruiting at 1 site Interventional Ages 18 and up

Adaptive interventions for patients with opioid use disorder in the emergency department

Official title: Adaptive Interventions for Emergency Department Patients With Opioid Use Disorder

Run by Rand · NCT06827288 · Data updated 2026-11-12

This study is testing a new way to help adults with opioid use disorder in the emergency department by offering different types of support to see if it encourages them to keep using buprenorphine for their recovery.

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment500 (estimated)
SponsorRand
Academic / other
Locations1 site (Colton, California)
StatusRecruiting
StartedOctober 4, 2024
Main results expectedJune 30, 2027
Study endsMarch 31, 2028
Registry record updatedFebruary 19, 2026
Trial IDNCT06827288 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are adults aged 18 or older who present to the emergency department with a probable diagnosis of opioid use disorder.

Probably not a fit

Patients who do not have a diagnosis of opioid use disorder or are unable to provide informed consent may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The ADAPT-ED study is designed to develop an adaptive intervention aimed at increasing long-term buprenorphine use among adults presenting to the emergency department with probable opioid use disorder. It employs a sequential multiple assignment randomized trial (SMART) methodology, which includes two stages of intervention. The first stage involves treatment initiation through either a Substance Use Navigator or a combination of this navigator with immediate telehealth access to outpatient providers. Non-responders in the second stage will receive either ongoing treatment from an emergency department-based team or enhanced support with behavioral health services.

Why it matters

Potential benefit: If successful, this study could significantly improve long-term treatment outcomes for patients with opioid use disorder by increasing buprenorphine use.

How similar studies have gone: Other studies have shown promise in using adaptive interventions for substance use disorders, suggesting that this approach may be effective.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Presented for ED care at ARMC
* Age 18 or older
* Probable OUD diagnosis
* Speak and understand English or Spanish
* Have capacity to give informed consent
* Provide a signed and dated informed consent form

Where it's running

  • Arrowhead Regional Medical Center
    Colton, California, United States
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.