Adaptive interventions for patients with opioid use disorder in the emergency department
Adaptive Interventions for Emergency Department Patients With Opioid Use Disorder
This study is testing a new way to help adults with opioid use disorder in the emergency department by offering different types of support to see if it encourages them to keep using buprenorphine for their recovery.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 500 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Rand Academic / other |
| Locations | 1 site (Colton, California) |
| Trial ID | NCT06827288 on ClinicalTrials.gov |
What this trial studies
The ADAPT-ED study is designed to develop an adaptive intervention aimed at increasing long-term buprenorphine use among adults presenting to the emergency department with probable opioid use disorder. It employs a sequential multiple assignment randomized trial (SMART) methodology, which includes two stages of intervention. The first stage involves treatment initiation through either a Substance Use Navigator or a combination of this navigator with immediate telehealth access to outpatient providers. Non-responders in the second stage will receive either ongoing treatment from an emergency department-based team or enhanced support with behavioral health services.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18 or older who present to the emergency department with a probable diagnosis of opioid use disorder.
Not a fit: Patients who do not have a diagnosis of opioid use disorder or are unable to provide informed consent may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could significantly improve long-term treatment outcomes for patients with opioid use disorder by increasing buprenorphine use.
How similar studies have performed: Other studies have shown promise in using adaptive interventions for substance use disorders, suggesting that this approach may be effective.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Presented for ED care at ARMC * Age 18 or older * Probable OUD diagnosis * Speak and understand English or Spanish * Have capacity to give informed consent * Provide a signed and dated informed consent form
Where this trial is running
Colton, California
- Arrowhead Regional Medical Center — Colton, California, United States (Recruiting)
Study contacts
- Study coordinator: Mariah Kalmin, PhD
- Email: mariahk@rand.org
- Phone: 310-393-0411
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.