Condition

Cocaine Use Disorder clinical trials and research

• 16Clinical trials
• 49NIH research projects
• 6Countries

Newest Cocaine Use Disorder clinical trials

All recruiting trials (16)

• HD-tDCS during CBT for Cocaine Use Disorder

  This study tests whether adding high-definition transcranial direct current stimulation to cognitive behavioral therapy helps adults with cocaine use disorder see if CBT works better.

  Recruiting Virginia Commonwealth University · Richmond, Virginia · NCT07829263

• Imaging Brain Mitochondrial Complex-I in Cocaine Use Disorder

  This study uses a PET scan with [F-18]BCPP-EF to see how mitochondrial Complex-I activity in the brain differs between people with cocaine use disorder and healthy controls.

  Recruiting Early Phase 1 University of Pittsburgh · Pittsburgh, Pennsylvania · NCT07773649

• Mild electrical brain stimulation (tDCS) with cognitive training to reduce cocaine cravings.

  This trial will test whether brief sessions of mild electrical brain stimulation (tDCS) combined with cognitive reappraisal training can lower craving in adults receiving inpatient treatment for cocaine use disorder.

  Recruiting Icahn School of Medicine at Mount Sinai · New York, New York · NCT07318480

• Clonidine to reduce craving in hospitalized people with cocaine or crack use disorder

  This will try clonidine versus clonazepam to see if clonidine lowers craving in people hospitalized for cocaine or crack use disorder.

  Recruiting Phase 4 University of Sao Paulo General Hospital · São Paulo, São Paulo · NCT07313371

• Semaglutide plus cognitive behavioral therapy for cocaine use disorder

  This trial will test whether adding semaglutide (a GLP-1 medication) to cognitive behavioral therapy helps adults with cocaine use disorder reduce craving and use.

  Recruiting Phase 2 The University of Texas Health Science Center, Houston · Houston, Texas · NCT07227948

• How cocaine use and stopping affects sleep and daily rhythms

  This study tries to see how cocaine use and stopping change sleep and circadian rhythms in adults entering supervised inpatient detoxification.

  Recruiting at 2 sites Hôpital le Vinatier · Bron, AURA and 2 other locations · NCT07119567

• Cue-reactivity incubation and cognitive reappraisal in cocaine use disorder

  This project will see if practicing cognitive reappraisal reduces cue-triggered brain responses and cravings in people with cocaine use disorder who are early in abstinence.

  Recruiting Icahn School of Medicine at Mount Sinai · New York, New York · NCT07091877

• See if pentoxifylline changes how cocaine affects adults with cocaine use disorder

  We will test whether taking pentoxifylline changes how cocaine affects adults with cocaine use disorder who are not currently seeking treatment.

  Recruiting Early Phase 1 University of Kentucky · Lexington, Kentucky · NCT07086794

• Investigating how Pavlovian mechanisms influence substance use behaviors

  This study is testing how certain learned responses might affect substance use behaviors in people with moderate to severe substance use disorders compared to healthy individuals.

  Recruiting Technische Universität Dresden · Dresden · NCT06701487

• Effects of ketamine and neurofeedback on cocaine addiction

  This study is testing whether combining ketamine with brain training can help people struggling with cocaine addiction reduce their use and improve their brain function.

  Recruiting Phase 2 Psychiatric University Hospital, Zurich · Zurich, Canton of Zurich · NCT06125054

• CRACK-TARGET 1: Observing behavioral sensitization and expectations in people with crack-cocaine dependence

  This project will try to see whether repeated crack-cocaine use produces measurable increases in movement by having 20 adults with severe crack dependence wear an activity monitor for three weeks and provide three blood samples.

  Recruiting at 2 sites Assistance Publique - Hôpitaux de Paris · Paris and 1 other locations · NCT06050304

• Using brain stimulation to improve outcomes in cocaine use disorder

  This study is testing if a type of brain stimulation can help adults with cocaine addiction feel more motivated and improve their treatment outcomes.

  Recruiting The University of Texas Health Science Center, Houston · Houston, Texas · NCT05986578

• rTMS plus cognitive-behavioral therapy for cocaine use disorder

  This study tests whether adding rapid magnetic brain stimulation to standard CBT helps people with cocaine use disorder reduce use and improve brain connectivity.

  Recruiting New York State Psychiatric Institute · New York, New York · NCT05974202

• Sustained-release dexamphetamine for cocaine use disorder in people also on methadone

  This study tests whether sustained-release dexamphetamine can help reduce cocaine use in people with cocaine use disorder who are also receiving methadone for opioid use disorder.

  Recruiting Phase 2 Parnassia Addiction Research Centre · The Hague · NCT05529927

• Imaging dopamine release in cocaine use disorders using PET scans

  This study is testing how dopamine levels change in the brains of people with cocaine use disorders when given a stimulant, to see if this can help find new ways to prevent relapse.

  Recruiting Early Phase 1 University of Pittsburgh · Pittsburgh, Pennsylvania · NCT05011760

• Imaging interactions between stress hormones and opioid receptors in cocaine use disorder

  This study is testing how stress hormones and certain brain receptors interact in people with cocaine use disorder to see if these interactions can help predict relapse.

  Recruiting Early Phase 1 University of Pittsburgh · Pittsburgh, Pennsylvania · NCT05008146

NIH-funded research (newest 40 of 49)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Modulating deep brain activity with focused ultrasound for cocaine use disorder

  A study will test whether targeting a deep brain region with focused ultrasound can alter brain signals related to craving in people with cocaine use disorder.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11611302

• Understanding how early life stress and cocaine exposure shape brain and behavior in adults

  This project follows a long-running study in monkeys to see how early maltreatment and adolescent cocaine use influence brain circuits and risk of addiction in adulthood.

  NIH research Emory University · Atlanta, United States · NIH-11465827

• Psilocybin-Assisted ACT for Co-Occurring Cocaine Use Disorder and Major Depressive Disorder

  A new treatment combines psilocybin with Acceptance and Commitment Therapy to help people who have both cocaine use disorder and major depressive disorder.

  NIH research University of Texas Hlth Sci Ctr Houston · Houston, United States · NIH-11458025

• Cholinergic Dysregulation and Cognitive Flexibility in Cocaine Use Disorder

  A research study explores how cocaine changes brain signaling to affect flexible thinking and decision-making in people with cocaine use disorder.

  NIH research Texas A&m University Health Science Ctr · College Station, United States · NIH-11455953

• Oligonucleotide therapy to help cocaine use disorder reach the brain

  A new ASO-based approach aims to deliver gene-targeting therapy across the blood–brain barrier to help people with cocaine use disorder.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11429935

• Accelerated TMS for Cocaine Use Disorder

  A new, faster brain-stimulation treatment is being tested to help adults with cocaine use disorder reduce cravings and use.

  NIH research University of Kentucky · Lexington, United States · NIH-11424703

• Focused ultrasound for reducing cocaine craving and use

  A study tests a gentle brain therapy using targeted ultrasound to help people with cocaine use disorder reduce craving and cocaine use.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11400264

• GPR52-based probes to help cocaine use disorder

  A human-focused research effort tests new GPR52-targeting molecules to help people with cocaine use disorder.

  NIH research University of Texas Med Br Galveston · Galveston, United States · NIH-11399734

• NOP receptors as targets for new treatments for cocaine use disorder (in nonhuman primates)

  A study in nonhuman primates is testing whether drugs that activate NOP receptors could help treat cocaine use disorder.

  NIH research Wake Forest University Health Sciences · Winston-Salem, United States · NIH-11399036

• NTX-2001: A TAAR1-based treatment to help adults with Cocaine Use Disorder

  A new drug candidate, NTX-2001, aims to help adults with Cocaine Use Disorder by reducing cravings and cocaine use with minimal disruption to normal brain function.

  NIH research Newleos Therapeutics, INC. · Hopkinton, United States · NIH-11390841

• Mitochondrial signaling dynamics in cocaine use disorder

  Aims to understand how cocaine changes mitochondria in dopamine neurons and tests targeted gene tweaks to see if those changes can be controlled.

  NIH research Research Triangle Institute · Research Triangle Park, United States · NIH-11377444

• Oxytocin as a potential therapy for endocrine problems in cocaine use disorder

  A study looking at whether oxytocin could help women with cocaine use disorder manage their hormonal dysfunction and reduce cocaine use.

  NIH research University of Mississippi Med Ctr · Jackson, United States · NIH-11366328

• M1 receptor–targeted approaches for cocaine addiction

  A Yale-led study looks at a brain receptor (M1) to understand if targeting it could help people with cocaine-use disorder.

  NIH research Yale University · New Haven, United States · NIH-11364180

• Boosting a serotonin receptor to reduce cocaine cravings and relapse

  New medicines that boost a specific serotonin receptor are being developed to help people with cocaine use disorder reduce cravings and prevent relapse.

  NIH research University of Texas Med Br Galveston · Galveston, United States · NIH-11332454

• Brain-penetrant NAC prodrug for cocaine use disorder

  A new brain-penetrant prodrug of N-acetylcysteine (SXC-2023) is being tested in adults with cocaine use disorder to see if it can safely help reduce use.

  NIH research Marquette University · Milwaukee, United States · NIH-11324833

• Changing how the brain values cocaine to help people stop using

  This project tries to change how people with cocaine use disorder think about future rewards so cocaine becomes less appealing.

  NIH research Virginia Polytechnic Inst and St Univ · Blacksburg, United States · NIH-11324584

• How cocaine changes brain cells and the blood-brain barrier in people with HIV

  This project looks at how cocaine use changes gene activity in different brain cells and the blood-brain barrier in people living with HIV.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11310161

• How immune cells and cocaine affect the brain's protective barrier in people with HIV

  The team will look at whether past or current cocaine use changes immune cells and weakens the blood-brain barrier in people living with HIV.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11306608

• Imaging brain energy use in cocaine use disorder with a PET tracer

  A new PET imaging study will look at brain energy use in people with cocaine use disorder to understand how cocaine affects brain metabolism.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11300404

• Cobenfy to help reduce cocaine use

  People with cocaine use disorder will try the medication Cobenfy to see whether it helps them choose money instead of cocaine.

  NIH research University of Kentucky · Lexington, United States · NIH-11274817

• Targeting a specific brain receptor to help people with cocaine addiction

  Developing new brain-penetrant medicines that block a specific nicotine-related receptor to help people with cocaine addiction reduce cravings and prevent relapse.

  NIH research University of Illinois at Chicago · Chicago, UNITED STATES · NIH-11248338

• Combining reward-based incentives with deep brain stimulation for cocaine addiction

  This project pairs incentive-based rewards (contingency management) with noninvasive deep transcranial magnetic stimulation to help people with cocaine addiction reduce use and prevent relapse.

  NIH research University of Texas Hlth Sci Ctr Houston · Houston, United States · NIH-11238161

• Developing a new treatment to help reduce cocaine cravings

  This study is looking at how a new medication might help people with cocaine addiction by targeting a specific protein in the brain that influences cravings and relapses, and it will be tested in lab models to see if it works safely.

  NIH research Iontx INC. · Galveston, United States · NIH-11168646

• Understanding brain receptors in cocaine use disorder

  This research explores a specific brain receptor, called M1, to find new ways to help people with cocaine use disorder.

  NIH research Yale University · New Haven, United States · NIH-11126696

• Understanding brain cell energy in cocaine use disorder

  This work explores how energy-producing parts of brain cells, called mitochondria, change in people with cocaine use disorder.

  NIH research Research Triangle Institute · Research Triangle Park, United States · NIH-11123317

• Investigating how cocaine use affects brain health in people with HIV

  This study is looking at how cocaine use affects brain health in people living with HIV, and it aims to understand the changes in the brain that can lead to thinking and memory problems, so if you're part of this group, your participation could help find better treatments for both HIV and drug use issues.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11117172

• How circadian rhythms affect cocaine use disorder

  This study is looking at how the body's natural clock affects cocaine addiction, exploring whether the time of day someone uses the drug can change their cravings and chances of relapse, with the hope of finding better ways to help people recover.

  NIH research Wake Forest University Health Sciences · Winston-Salem, United States · NIH-11110370

• Using Semaglutide to Help Treat Cocaine Use Disorder

  This study is looking at whether semaglutide, a medication usually used for diabetes and weight loss, can help people with cocaine addiction by improving their treatment and making therapy more effective.

  NIH research University of Texas Hlth Sci Ctr Houston · Houston, United States · NIH-11104610

• Using focused ultrasound to change brain activity related to cocaine addiction

  This study is exploring whether a special ultrasound technique can help change brain activity in people with cocaine use disorder to reduce cravings and improve treatment, and it involves healthy volunteers doing a fun reward task to see how it works.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11101355

• How HIV and cocaine use affect the blood-brain barrier

  This study is looking at how using cocaine might affect the brain's protective barrier in people living with HIV, and how this could impact their thinking and memory.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11096032

• Understanding how cocaine affects decision-making in addiction

  This study is looking at how the timing of rewards affects the way people with cocaine use disorder think about cocaine compared to other things they might enjoy, and it aims to find new ways to help those struggling with this addiction.

  NIH research Virginia Polytechnic Inst and St Univ · Blacksburg, United States · NIH-11081037

• Investigating brain changes in people with cocaine use disorder

  This study is looking at how cocaine use changes the brain's connections, especially in an area that helps with decision-making, to better understand cravings and behaviors in people with cocaine addiction, and it involves using a special imaging technique to see these changes in the brain.

  NIH research Yale University · New Haven, United States · NIH-11078350

• New oral medication to help treat cocaine addiction

  This study is testing a new pill called OMS182399 that aims to help people struggling with cocaine use by reducing cravings and restoring balance in the brain, since there aren't any approved medications for this condition right now.

  NIH research Omeros Corporation · Seattle, United States · NIH-11059141

• Investigating brain receptors related to cocaine use disorder

  This study is looking at how certain brain receptors are involved in cocaine addiction to find new ways to help people who are struggling with this issue.

  NIH research Yale University · New Haven, United States · NIH-11055793

• Targeting specific receptors to help treat cocaine addiction

  This study is looking at new medications to help people struggling with cocaine addiction by targeting a specific brain receptor, and it aims to show how these new compounds can reduce cravings and prevent relapse in animal models, which could eventually lead to a new treatment for those in need.

  NIH research University of Illinois at Chicago · Chicago, UNITED STATES · NIH-11043406

• Targeting Nr4a1 to help treat cocaine addiction.

  This study is exploring a new way to help people with cocaine addiction by looking at a protein that might help reduce cravings, and they’re working on a treatment using a natural compound that activates this protein.

  NIH research Rafias LLC · Philadelphia, United States · NIH-11032992

• Using Metformin to help treat cocaine addiction

  This study is looking at whether metformin, a medicine usually used for Type II diabetes, can help people recovering from cocaine addiction by reducing cravings and the chance of relapse.

  NIH research University of Minnesota · Minneapolis, United States · NIH-10936529

• Investigating how serotonin receptors affect cocaine addiction in rats

  This study is looking at how a specific serotonin receptor in the brain might affect cocaine addiction, using rats to help find new ways to treat people struggling with this issue.

  NIH research Praeventix, LLC · Exton, United States · NIH-10903814

• Understanding how cocaine affects energy production in brain cells

  This study is looking at how cocaine affects the energy-producing parts of brain cells that help control mood and behavior, and it aims to find out how these changes might help us develop better treatments for people struggling with cocaine addiction.

  NIH research Research Triangle Institute · Research Triangle Park, United States · NIH-10903745

• Exploring how sex differences affect dopamine release in cocaine use disorder

  This study is looking at how men and women’s brains respond differently to cocaine by focusing on a chemical called dopamine, which is important for feeling pleasure, and how certain brain receptors affect this response; the goal is to find better ways to help people struggling with cocaine addiction.

  NIH research Vanderbilt University · Nashville, UNITED STATES · NIH-10901886

Related topics

Quick answers

How many Cocaine Use Disorder clinical trials are recruiting right now?

16, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 6 countries. The most sites are in United States (10 trials), France (2 trials), Brazil (1 trial), Netherlands (1 trial), Germany (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Early Phase 1: 4, Phase 2: 3, Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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